Dose-Response Table
Bullfrog (Lithobates catesbeianus formerly Rana catesbeiana)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries | Lab |
---|---|---|---|---|---|---|---|---|---|
PENOXSULAM | 7.52 mg/L | LC50 | Not Reported | Tadpole | 6 | Experimental Frog Farm, São Paulo | Toxicity Factor Datasets | BRAZIL | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 34.4 ug/l (95% CL: 31.1 - 38.1 ug/l) | LC50 | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | Toxicity Factor Datasets | embryo-larvae, 11d | Laboratory | |
DIELDRIN | 25.1 ug/l | LOAEL, based on mortality but gross spinal deformities also observed | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | Toxicity Factor Datasets | embryo-larvae, 11d | Laboratory | |
DIELDRIN | 11.0 ug/l | NOAEL | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | Toxicity Factor Datasets | embryo-larvae, 11d | Laboratory |
American Kestrel (Falco sparverius)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PARATHION | 56% decrease at 4.6 ppm | mean plasma cholinesterase activity relative to control | Not Reported | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
FLUORIDE, SODIUM | decreased at 2240 ppm | bonebreaking strength | Both Male and Female | Juvenile | 9-10/group | Toxicity Factor Datasets | 7 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PARAQUAT | 51% @ 60 mg/kg | percent increase over controls in kidney to body weight ratio | Not Reported | Juvenile | 11/group | Toxicity Factor Datasets | Laboratory | |
PARAQUAT | no effect | percent increase over controls in lung to body weight ratio | Not Reported | Juvenile | 11/group | Toxicity Factor Datasets | Laboratory | |
PARAQUAT | decreased @ 25, 60 mg/kg | skeletal growth (humerus, femur, radius-ulna, tibia-fibula) | Not Reported | Juvenile | 11/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 153 | aminopyrine N-demethylase and aldrin epoxidase activities in liver | Female | Adult | 5-6/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 105 | aminopyrine N-demethylase activity in liver | Female | Adult | 5-6/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 126 | 7-ethoxyresorufin O-deethylase and aldrin epoxidase activities in liver | Female | Adult | 5-6/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Clapper Rail (Rallus longirostris)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | 1612 ppm | 5 day dietary LC50 | Male | Juvenile | 7 birds | Toxicity Factor Datasets | Laboratory | |
DDT (4,4'-) | 1896 ppm | 5 day dietary LC50 | Female | Juvenile | 4 birds | Toxicity Factor Datasets | Laboratory |
Mourning Dove (Zenaida macroura)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | female fertility or productivity, egg weight and size | Female | Adult | 25 birds/dose | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | decreased | hatchability | Not Reported | Hatchling | 25 birds/dose | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | no effect | body weight at hatch | Not Reported | Hatchling | 25 birds/dose | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | no effect | mortality | Female | Adult | 25 birds/dose | Toxicity Factor Datasets | Laboratory |
Mallard duck (Anas platyrhynchos)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DICROTOPHOS | decreased @ 55 and 145 ppm | consumption of treated diet compared with controls | Not Reported | Juvenile | 8-10/dose | Toxicity Factor Datasets | 5 days | Laboratory | |
DICROTOPHOS | 506.7 (coeff. of variation = 40.3%) | 5 day dietary LC50 | Not Reported | Juvenile | 8-10/dose | Toxicity Factor Datasets | 10 days | Laboratory | |
DIELDRIN | 200.7 (coeff. of variation 22.3%) | 5 day dietary LC50 | Not Reported | Juvenile | 8-10/dose | Toxicity Factor Datasets | 5 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries |
---|---|---|---|---|---|---|---|---|
CARBOFURAN | increased @ 132 and 264 g/ha | occurrence of acute poisoning symptoms compared with controls | Not Reported | Juvenile | 29-38/group | Toxicity Factor Datasets | CANADA |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
FENSULFOTHION | 48.9% (7.6 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory | |
FONOFOS | 67.1% (4.9 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory | |
MALATHION | 67% (11.6 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory | |
PARATHION | 74.6% (12.4 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEPTOPHOS | decreased @ 60, 270 ppm | plasma alkaline phosphatase activity compared with controls | Female | Juvenile | 6/group | Toxicity Factor Datasets | 20 wks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 12 ug/g (48%), 36 ug/g (29%), 108 ug/g (0%) | % surviving to hatch versus controls | Not Reported | Hatchling | 12/group | Toxicity Factor Datasets | 72 hr of incubation (time of treatment) | Laboratory | |
EPN | decreased @ 12, 36 ug/g | brain weight, protein content, acetylcholinesterase and neurotoxic esterase versus controls | Not Reported | Hatchling | 12/group | Toxicity Factor Datasets | 72 hr of incubation (time of treatment) | Laboratory | |
EPN | decreased @ 12, 36 ug/g | plasma cholinesterase activity, hemoglobin and uric acid content | Not Reported | Hatchling | 12/group | Toxicity Factor Datasets | 72 hr of incubation (time of treatment) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
N-BUTYL ALCOHOL | 0 survival @ 100% solution, incubation days 3 or 8 exposure | embryo survival through incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory | |
XYLENE | no effect | embryo survival, size, and incidence of abnormalities through incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | incidence of ducklings with histopathological lesions versus controls | Not Reported | Juvenile | 15 birds/group | Toxicity Factor Datasets | 1 d | Laboratory | |
ARSENATE, SODIUM, SELENOMETHIONINE | decreased @ 60 ppm Se, 200 ppm As | growth rate of body weight versus controls | Not Reported | Juvenile | 15 birds/group | Toxicity Factor Datasets | 1 d | Laboratory | |
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | glutathione peroxidase activity versus controls | Not Reported | Juvenile | 15 birds/group | Toxicity Factor Datasets | 1 d | Laboratory | |
ARSENATE, SODIUM, SELENOMETHIONINE | increased (100%) @ 60 ppm Se and (53%) @ 200 ppm As | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | no effects | reproductive success (number of eggs laid, hatchability, duckling survival) compared to controls | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory | |
NICKEL SULFATE | increased @ 12.5, 50, 200, 800 ppm diet | kidney, blood, liver, and feather concentrations of Ni compared to controls | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory | |
NICKEL SULFATE | 1.94 (kidney), 0.52 (liver), 0.139 (blood), 68.06 (feathers) ppm, wet wt | mean tissue concentrations @ 800 ppm Ni in diet | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SALINE WATER | increased | plasma protein levels; serum osmolality; salt, kidney and adrenal gland size versus controls | Not Reported | Juvenile | 10 birds/group | Toxicity Factor Datasets | 2 d | Laboratory | |
SALINE WATER | increased @ 67,000 umhos/cm (100%), 35,000 umhos/cm (100%), 21,500 umhos/cm (78%), and 20,000 umhos/cm (60%) | mortality versus controls | Not Reported | Juvenile | 10 birds/group | Toxicity Factor Datasets | 2 d | Laboratory | |
SALINE WATER | increased @ 20,000 umhos/cm and above | thymus size versus controls | Not Reported | Juvenile | 10 birds/group | Toxicity Factor Datasets | 2 d | Laboratory | |
SALINE WATER | decreased @ 20,000 and 21,500 umhos/cm | body weight by day 14 versus controls | Not Reported | Juvenile | 10 birds/group | Toxicity Factor Datasets | 2 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 20, 40 ppm | hepatic malondialdehyde concentrations versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory | |
SELENITE, SODIUM | increased @ 40 ppm | hepatic malondialdehyde concentrations versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory | |
SELENOMETHIONINE | decreased @ 20, 40 ppm | hepatic protein concentrations versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory | |
SELENITE, SODIUM | increased @ 20, 40 ppm | hepatic protein concentrations versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | 0.10 (@ 0 ppm), 10.13 (@ 5 ppm), 16.25 (@ 10 ppm), 42.21 (@ 20 ppm) ppm, wet wt | mean Cd concentrations in liver by 12 wks of treatment | Not Reported | Juvenile | 12 birds per timexdose treatment | day old | Toxicity Factor Datasets | Laboratory |
CADMIUM CHLORIDE | no effect | body weight, liver weight, and femur density compared to controls | Not Reported | Juvenile | 12 birds per timexdose treatment | day old | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al or 0.277 mol sulfate/kg | growth of tibia versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | Toxicity Factor Datasets | 3 d | Laboratory | |
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al | tibial dry weight, and ash and calcium content versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | Toxicity Factor Datasets | 3 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | 4.6 (0.18) ppm B @ 450 ppm B; 8.5 (0.34) ppm B @ 900 ppm B; 3.7 (0.16) ppm Se @ 3.5 ppm Se; 6.2 (0.27) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in liver | Both Male and Female | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | 6.5 (0.25) ppm B @ 450 ppm B; 11 (0.4) ppm B @ 900 ppm B; 3.5 (0.10) ppm Se @ 3.5 ppm Se; 7.1 (0.28) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in egg | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | body weight versus controls | Both Male and Female | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | decreased @ 900 ppm B | liver weight versus 450 ppm B group | Male | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | increased @ 869 and 954 ug/g | protoporphyrin versus corn or complete diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | reduced @ 869 and 954 ug/g | delta aminolevulinic acid dehydratase activity versus corn or complete diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | no effect | body weight versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 869 ug/g, corn diet | mortality versus corn diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | reduced @ 828 ug/g | hemoglobin concentrations versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 869 and 954 ug/g | incidence of renal tubular intranuclear inclusion bodies versus corn or complete diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CYANOFENPHOS | increased @ 2.0, or 4.0 mg cyanofen/kg/d, 10 mg leptophos/kg/d. | incidence of histological lesions in axons and myelin sheaths | Both Male and Female | Juvenile | 10 | laboratory | Toxicity Factor Datasets | 1 week | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
MALATHION | increased @ 125 lb/acre | cumulative mortality by day 18 compared with controls | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory | |
MALATHION | 118 (day 3), 101 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory | |
PARATHION | 41(day 3), 39 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
VANADYL SULFATE | increased @ 100 ppm (maximum = 106 +/- 19 ppb, wet wt) | vanadium concentration in blood (sampled at 3 wk intervals) | Both Male and Female | Adult | 5 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
VANADYL SULFATE | brain, 9(1); fat, 20(11); kidney, 273(49); liver, 657(113), male femur 274(47); female femur 3327(2208) ppm, wet wt | mean (SE) vanadium concentrations @ 100 ppm dose in brain, fat, kidney, liver, and femur | Both Male and Female | Adult | 5 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
VANADYL SULFATE | <0.02 ppb, wet wt @ 1, 10 ppm; 63 ppb, wet wt @ 100 ppm | vanadium concentration in eggs | Female | Adult | 5 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM, SELENOMETHIONINE | no effect | tarsus length, 10th primary length, heart weight versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | Laboratory | |
SELENITE, SODIUM | 18(4.8) ppm, wet wt @ 40 ppm; 6.9(2.07) ppm, wet wt @ 80 ppm | mean liver concentrations (SE) in ducklings fed selenite that died | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | Laboratory | |
SELENOMETHIONINE | 60(14.2) ppm, wet wt @ 40 ppm; 51(5.2) ppm, wet wt @ 80 ppm | mean liver concentrations (SE) in ducklings fed selenomethionine that died | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased @ 100, 250, 500 mg/kg bw | thyroid wt/body wt and liver wt/body wt ratios versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | increased @ 250, 500 mg/kg bw | lymphocyte proliferation to PHA versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 5 shot (33%) and repeated 5 shot (40%) | percent mortality versus controls | Both Male and Female | Not Reported | 5-6/group | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | increased @ all doses | Pb concentrations in wing bone and liver | Both Male and Female | Not Reported | 5-6/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CYANIDE | decreased @ all doses | ATP levels in liver and brain tissues versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory | |
CYANIDE | no effect | ATP levels in heart versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | decreased @ 25 ppm/3 wks, 5 ppm/12 wks | delta-aminolevulinic acid dehydratase activity in blood versus controls | Male | Adult | 20/dose; 5/dose x time group | Toxicity Factor Datasets | 1 yr | Laboratory | |
LEAD NITRATE | increased @ 25 ppm/3wks | accumulation in livers and kidneys versus controls | Male | Adult | 20/dose; 5/dose x time group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 32 ppm | incidence of liver histopathological lesions, liver:body wt ratios versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory | |
SELENOMETHIONINE | increased @ 32 ppm | plasma alkaline phosphatase activity and total protein levels versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CHLORPYRIFOS | 357 ppm | 11 day dietary LC50 | Not Reported | Juvenile | 10/group | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 800, 1200 ppm | incidence of clinical signs and mortality | Both Male and Female | Juvenile | 36 birds/dose | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
GLYPHOSATE | increased @ 50, 90 percent | population density 2 years post-spray versus controls | Not Reported | Not Reported | 3-6 sample wetlands/treatment | near Lakota (48deg03'N, 98deg21'W) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decreased @ 5 uL/egg | embryonic weight (females) and crown rump length (both sexes) | Both Male and Female | Hatchling | 65 eggs/group | Toxicity Factor Datasets | 3 days | Laboratory |
Pacific Treefrog (Pseudacris regilla formerly Hyla regilla)
Chemical | Endpoint Value | Endpoint Description | Units | Sex | Life Cycle Stage | Sample Size | Location | Type | Error | Lab |
---|---|---|---|---|---|---|---|---|---|---|
AMMONIUM NITRATE | 3.3 | NOAEL for body weight and length | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | Laboratory | ||
AMMONIUM CHLORIDE | 30.3 | 10-d LC50 for embryos | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | 27.0 - 33.4 (95% CI) | Laboratory | |
AMMONIUM CHLORIDE | 24.9 | LOAEL for body weight and length and deformities | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | Laboratory | ||
AMMONIUM CHLORIDE | 12.8 | NOAEL for body weight and length and deformities | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | Laboratory |
Double-crested Cormorant (Phalacrocorax auritus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ 5.4, 10.7, 11.7 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 175, 349, 698 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 4.0 ug/kg egg (0.8-7.2) | LD50 (95% confidence limits) | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | 177 ug/kg egg (77-264) | LD50 (95% confidence limits) | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased @ 5 ug/kg | weight of heart, liver and spleen versus controls | Not Reported | Embryo | 15-60/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries |
---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | decreased at 276, 672, 1606 ng/kg | Mean yolk weight of eggs | Female | Both Adults and Juveniles | 5-12 eggs/dose | Saskatchewan, British Columbia, Lake Ontario | Toxicity Factor Datasets | CANADA |
POLYCHLORINATED BIPHENYLS | increased at 1606 ng/kg | total hepatic cytochrome P450 content | Not Reported | Hatchling | 5-12 eggs/dose | Saskatchewan, British Columbia, Lake Ontario | Toxicity Factor Datasets | CANADA |
Deer Mouse (Peromyscus maniculatus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CHLOROCHOLINE CHLORIDE | increase @ 1, 20, 80 mg/kg bw/d | liver weight to bw ratio | Female | Adult | 12/dose | Toxicity Factor Datasets | Laboratory | |
CHLOROCHOLINE CHLORIDE | increase @ 1-80 mg/kg | thymus weight to bw ratios | Female | Adult | 12/dose | Toxicity Factor Datasets | Laboratory | |
CHLOROCHOLINE CHLORIDE | increase @ 80 mg/kg bw/d | white blood cell counts | Female | Adult | 12/dose | Toxicity Factor Datasets | Laboratory |
Loggerhead Shrike (Lanius ludovicianus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | increased at 1 mg/kg | latency to formation of natural prey killing behaviors | Not Reported | Juvenile | 10-11/dose | collected in San Diego County, CA | Toxicity Factor Datasets | 1 day post-hatch (begin) | Laboratory |