LEAD COMPOUNDS |
TOX-EXP IND - accumulation |
mean (SE) wet wt Pb concentrations in blood and liver |
4.1(1.03) ppm in blood, 13(1.2) ppm in liver @ 954 ug/g, complete diet; 4.0(0.58) ppm in blood, 38(6.5) ppm in liver @ 869 ug/g, corn diet |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
hematocrit versus controls |
reduced @ 1284 ug/g |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - whole animal |
body weight versus controls |
no effect |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - organ/system effects |
occurrence of renal tubular nuclear inclusion bodies versus controls |
increased @ 642 and 1284 ug/g |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
hemoglobin concentrations versus controls |
reduced @ 828 ug/g |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-EXP IND - accumulation |
mean (SE) wet wt Pb concentrations in blood |
3.0(0.30) ppm @ 642 ug/g Pb; 6.8(0.84) ppm @ 1284 ug/g Pb |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
delta aminolevulinic acid dehydratase activity versus controls |
reduced @ all doses |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-EXP IND - accumulation |
mean (SE) wet wt Pb concentrations in liver |
9.1(0.61) ppm @ 642 ug/g Pb; 16(1.5) ppm @ 1284 ug/g Pb |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
occurrence of intranuclear inclusion bodies in kidneys versus controls |
increased @ 414, 828 ug/g |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - whole animal |
body weight compared to corn diet controls |
reduced @ 869 ug/g, corn diet |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - whole animal |
occurrence of lead poisoning signs versus controls |
increased @ 828 ug/g |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
hemoglobin concentration versus corn diet controls |
reduced @ 869 ug/g, corn diet |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
protoporphyrin levels in blood versus controls |
increased @ all doses |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
protoporphyrin versus corn or complete diet controls |
increased @ 869 and 954 ug/g |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-EXP IND - accumulation |
mean(SE) wet wt concentrations of lead in liver |
4.6(0.66) ppm @ 103 ug/g Pb; 9.3(0.82) ppm @ 207 ug/g Pb; 12(1.3) ppm @ 414 ug/g Pb; 28(4.6) ppm @ 828 ug/g Pb |
10/ Pb treatment; 20/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
delta aminolevulinic acid dehydratase activity versus corn or complete diet controls |
reduced @ 869 and 954 ug/g |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - whole animal |
body weight versus controls |
no effect |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-MORT - dose-response data |
mortality versus corn diet controls |
increased @ 869 ug/g, corn diet |
5/ Pb treatment;3/control treatments |
Adult |
15 wks |
Toxicity Factor Datasets |
LEAD COMPOUNDS |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
delta aminolevulinic acid dehydratase activity and hemoglobin concentrations |
reduced @ 624 and 1284 ug/g |
10/ Pb treatment; 5/control treatment |
Adult |
10 wks |
Toxicity Factor Datasets |