Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards

Author(s)

Hoffman, David J., Louis Sileo and Helen C. Murray

Year

Sun, 01/01/1984 - 12:00

Article Title

Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards

Volume

Pages

128-136

Start Page Number

128

Final Page

136

Review

Datapoints

Displaying 1 - 10 of 10 datapoints.

Species: Mallard duck (Anas platyrhynchos)
Chemical	Toxicity Endpoint Type	Endpoint Description	Endpoint Value	Sample Size	Life Cycle Stage	Study Duration	Type
EPN	TOX-Non-Repro-Sublethal - behavioral effects	food consumption and body weight compared with controls	decreased @ 90, 270 ppm	6/group	Juvenile	90 d	Toxicity Factor Datasets
EPN	TOX-Non-Repro-Sublethal - behavioral effects	incidence of hyperactivity, ataxia, and/or paralysis compared with controls	increased @ all doses	6/group	Juvenile	90 d	Toxicity Factor Datasets
EPN	TOX-Non-Repro-Sublethal - organ/system effects	incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls	increased @ 30, 90, 270 ppm	6/group	Juvenile	90 d	Toxicity Factor Datasets
EPN	TOX-Non-Repro-Sublethal - cellular/biochemical effects	activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls	decreased @ all doses	6/group	Juvenile	90 d	Toxicity Factor Datasets
EPN	TOX-Non-Repro-Sublethal - cellular/biochemical effects	plasma alkaline phosphatase activity compared with controls	decreased @ 90, 270 pmm	6/group	Juvenile	90 d	Toxicity Factor Datasets
LEPTOPHOS	TOX-Non-Repro-Sublethal - whole animal	body weight compared with controls	decreased @ 270, 540 ppm	6/group	Juvenile	90 d	Toxicity Factor Datasets
LEPTOPHOS	TOX-Non-Repro-Sublethal - organ/system effects	incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls	increased @ all doses	6/group	Juvenile	90 d	Toxicity Factor Datasets
LEPTOPHOS	TOX-Non-Repro-Sublethal - organ/system effects	brain weight compared with controls	decreased @ 270 ppm	6/group	Juvenile	90 d	Toxicity Factor Datasets
LEPTOPHOS	TOX-Non-Repro-Sublethal - cellular/biochemical effects	activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls	decreased @ all doses	6/group	Juvenile	90 d	Toxicity Factor Datasets
LEPTOPHOS	TOX-Non-Repro-Sublethal - cellular/biochemical effects	plasma alkaline phosphatase activity compared with controls	decreased @ 60, 270 ppm	6/group	Juvenile	90 d	Toxicity Factor Datasets