Laboratory
Mallard duck (Anas platyrhynchos)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
IRON (elemental), LEAD (elemental) | no effect | serum enzyme levels versus controls (at 30 or 60 d post dose) | Male | Adult | 2/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CYANIDE | increased | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in brain versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory | |
CYANIDE | no effect | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in liver and heart versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | decreased @ 3,000, 30,000 ppm, incubation day 3 exposure | embyronic length and weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory | |
METHYLMERCURY CHLORIDE | decreased @ all doses | embryo length or weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased in Pb/commerical (hemoglobin only), Pb/corn+Ca, and Pb/corn only | red blood cell counts, packed cell volume, hemoglobin concentration versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 |
Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | increased with Pb/corn + Ca, Pb/corn only | blood protoporphyrin concentrations versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 |
Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE, COPPER COMPOUNDS, LEAD CHLORIDE | 56.7(7.7) @ 100 ppm Cd; 37.7 (3.7) @ 50 ppm Cd + 50 ppm Pb (ug/g, dry wt) | mean (SE) Cu concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | Toxicity Factor Datasets | 128 d (at initiation) | Laboratory | |
CADMIUM CHLORIDE, LEAD CHLORIDE, ZINC COMPOUNDS | 99 (6) @ 110 ppm Cd; 125 (7) @ 100 ppm Cd; 100 (5) @ 5 ppm Cd + 5 ppm Pb; 112 (2) @ 50 ppm Cd + 50 ppm Pb | mean (SE) Zn concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | Toxicity Factor Datasets | 128 d (at initiation) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | incidence of histopathological lesions, and liver, brain, and spleen weights | Both Male and Female | Juvenile | 30 birds/group | Toxicity Factor Datasets | Laboratory | |
ARSENATE, SODIUM | increased @ 300 ppm | plasma biochemistry changes versus controls | Both Male and Female | Juvenile | 30 birds/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | no effects | body wt, liver wt:brain wt, kidney wt:brain wt, duodenal wt compared to controls | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory | |
NICKEL SULFATE | no effects | plasma biochemistry compared to controls | Male | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | increased to 0.010 (@ 20 ppm), 0.040 (@ 200 ppm) ppm, wet wt | Cd concentrations in eggs versus controls | Both Male and Female | Adult | 15 eggs (20 ppm), 3 eggs (200 ppm) | Toxicity Factor Datasets | 1 yr | Laboratory | |
CADMIUM CHLORIDE | increased @ 200 ppm/60 or 90 d of treatment, 30 d post-treatment | mean kidney weight versus controls | Both Male and Female | Adult | 10 kidneys/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.4 +/- 0.18 (@ 1 ppm, no DDE), 8.7 +/- 0.87 (@ 5 ppm, no DDE) ppm Hg, wet wt | mean Hg concentration in third egg laid in clutch (mean +/- SE) | Female | Adult | 10/group | Toxicity Factor Datasets | Laboratory | |
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.0 +/- 0.06 (@ 1 ppm Hg, no DDE), 5.3 +/- 0.56 (@ 5 ppm Hg, no DDE) ppm Hg, wet wt | Hg concentration in breast muscle (mean +/- SE) | Female | Adult | 10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | 25-27 (@ 30 ppm as Se-L-met or Se-DL-met), 13 (@ 30 ppm as yeast) ppm, wet wt | mean Se concentrations in liver | Not Reported | Juvenile | 25 birds/group | Toxicity Factor Datasets | 1 day | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 5, 10, 25 ppm (as selenite), 10 ppm (as selenomethionine) | plasma glutathione peroxidase activity in hatchlings compared to controls | Not Reported | Juvenile | 5-11 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 16, 32 ppm | liver reduced gluthathione, oxidized glutathione, malondialdehyde concentrations versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory | |
SELENOMETHIONINE | increased @ 2 ppm or greater | Se concentrations in liver versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ENDRIN | 22.3 (9.88-50.3), 3.37 (2.36-4.80), 2.90 (2.17-3.88), 5.33 (3.67-7.73) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory | |
CHLORPYRIFOS | 50.4 mg/kg | LD50 | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 30 days | Laboratory | |
CARBOFURAN | 0.370 (0.283-0.484), 0.628 (0.530-0.744), 0.510 (0.410-0.635), 0.415 (0.333-0.516) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | body weight compared to controls | Both Male and Female | Adult | 20 females, 10 males/group | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | no effect | egg production versus controls | Female | Adult | 20 females/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 42.5 ug/g lipid, 14.6 ug/g skin, 1.6 ug/g brain, 2.5 ug/g liver, 1.2 ug/g muscle at 26.2 ug/g food | mean of day 5, 7, 8 (approx. steady state) tissue concentrations | Not Reported | Juvenile | 6 | Toxicity Factor Datasets | 1 d | Laboratory | |
DIELDRIN | 80.7 ug/g lipid, 30.1 ug/g skin, 1.6 ug/g brain, 4.1 ug/g liver, 1.8 ug/g muscle at 49.3 ug/g food | mean of day 5, 7, 8 (approx. steady state) tissue concentrations | Not Reported | Juvenile | 6 | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase | body temperature at an ambient temperature of -17C, compared to control | Not Reported | Adult | 5/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
BORIC ACID | no effect | eggshell thickness and Ratcliffe index of eggshell quality | Female | Adult | 15/dose | Toxicity Factor Datasets | Laboratory | |
BORIC ACID | increase @ 1000 ppm | % embryo mortality (day 15 to hatch) and duckling mortality (hatch to day 7) | Both Male and Female | Both Adults and Juveniles | 11-23/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase | plasma triglyceride and sodium concentrations, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | Toxicity Factor Datasets | 4 d | Laboratory | |
CRUDE OILS | decrease | hematocrit and plasma cholesterol concentration, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | Toxicity Factor Datasets | 4 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SEWAGE SLUDGE | no effect | immune defenses; resistance to Pasturella multocida estimated by % mortality 14 d after challenge, compared to controls | Male | Adult | 10/dose | Toxicity Factor Datasets | Laboratory | |
SEWAGE SLUDGE | increase @ 20% Milorganite or Metrogro | liver cadmium concentrations; compared to controls | Male | Adult | 10/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | decreased @ 235.0, 484.2, 972.0 ug/g (nominal concentrations) | body weight versus controls | Both Male and Female | Adult | 5 males, 5 females/dose | Toxicity Factor Datasets | Laboratory | |
PHOSPHORUS (YELLOW OR WHITE) | 91.1 ug/g | No Observable Effect Level, based on mortality, pathology, clinical signs | Both Male and Female | Adult | 5 males, 5 females/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
EMAMECTIN BENZOATE | no effect | incidence of signs of toxicity and body weight versus controls | Both Male and Female | Adult | 16 pairs/group | Toxicity Factor Datasets | 22 weeks | Laboratory | |
EMAMECTIN BENZOATE | no effect | feed consumption versus controls | Both Male and Female | Adult | 16 pairs/group | Toxicity Factor Datasets | 22 weeks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al or 0.277 mol sulfate/kg | growth of tibia versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | Toxicity Factor Datasets | 3 d | Laboratory | |
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al | tibial dry weight, and ash and calcium content versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | Toxicity Factor Datasets | 3 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | 4.6 (0.18) ppm B @ 450 ppm B; 8.5 (0.34) ppm B @ 900 ppm B; 3.7 (0.16) ppm Se @ 3.5 ppm Se; 6.2 (0.27) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in liver | Both Male and Female | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | 6.5 (0.25) ppm B @ 450 ppm B; 11 (0.4) ppm B @ 900 ppm B; 3.5 (0.10) ppm Se @ 3.5 ppm Se; 7.1 (0.28) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in egg | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | reduced @ 869 ug/g, corn diet | body weight compared to corn diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | reduced @ 869 ug/g, corn diet | hemoglobin concentration versus corn diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | reduced with selenized yeast | body weight of 6 day old ducklings versus controls | Both Male and Female | Both Adults and Juveniles | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | increased with seleno-D,L-methionine, seleno-L-methionine, or selenized yeast | incidence of embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | increased @ 10 ppm Hg | oxidized glutathione (GSSG) level versus controls | Male | Adult | 12/treatment | Toxicity Factor Datasets | 18 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Bi | weight of eggs that did not hatch versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | Toxicity Factor Datasets | 6-8 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ all doses | Pb concentrations in wing bone and liver | Both Male and Female | Not Reported | 5-6/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | increased with all doses | brain, liver, and adipose dieldrin concentrations | Both Male and Female | Juvenile | 4-6 per group | Toxicity Factor Datasets | 75 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD ACETATE | decreased | hemoglobin concentration versus controls | Male | Adult | 10 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | hepatic microsomal enzyme activity (aniline hydroxylase and aminopyrine N-demethylase) | Female | Adult | 18/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no differences | mean body weight and organ weights compared among lead, iron and bismuth dosed birds | Both Male and Female | Adult | 5 males, 5 females per group | Toxicity Factor Datasets | 6-8 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | significant effect | PCB treatment altered the shape of the body weight growth curve but not the asymptotic weight | Both Male and Female | Juvenile | 15/dose | Toxicity Factor Datasets | 1d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 5.5 - 95 | steady state bioconcentration factor for muscle, calculated on a wet weight basis; range for 7 doses | Not Reported | Juvenile | 8-16/dose | Toxicity Factor Datasets | 1 d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 10.3 (0.9 SE) ug/g wet wt. @ 3 ug/g diet; 91.5 (1.5 SE) @ 30 ug/g diet; 332.0 (26.0 SE) @ 100 ug/g diet | mean egg yolk concentrations after 37-42 d on DDE diet | Female | Adult | 5-10/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | no effect | body weight at end of experiment | Female | Adult | 4/dose/sampling time | Toxicity Factor Datasets | 80 d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DICROTOPHOS | 101.8 (coeff. of variation = 21.6%) | 5 day dietary LC50 | Not Reported | Juvenile | 8-10/dose | Toxicity Factor Datasets | 5 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
MALATHION | 90.6% @ 5 mg/L | brain acetylcholinesterase activity compared with controls | Not Reported | Juvenile | 4-5/dose | Toxicity Factor Datasets | 2 weeks old | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ASULAM | 10% @ 4000 mg/kg | percent mortality after 21 days | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 7 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIAZINON | 74 (day 3), 79 (day 8) lb/acre LC50 | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PARATHION | 4/36 | mortality incidence by 20 hrs post-dose | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEPTOPHOS | decreased @ all doses | activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls | Female | Juvenile | 6/group | Toxicity Factor Datasets | 20 wks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, DDE (4,4'-) | no effect | food consumption rate (181 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 15 ul/egg | red blood cell and liver ALAD activity and hemoglobin concentration, compared to controls | Both Male and Female | Embryo | 100 eggs/dose | Toxicity Factor Datasets | days 2-16 of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 7, 14, 21 d post-dose | concentration of lead in blood versus controls | Male | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 10,20,40 ppm | incidence of altered hepatic glutathione metabolism versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | decreased @ 450 ppm | body and liver weights compared to controls | Not Reported | Adult | 12 birds/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase @ 1% and 3% | hepatic microsomal naphthalene metabolism (nmol/min/mg protein), compared to control, in adult females and in neonatal ducklings hatched from eggs laid by females (1% Prudhoe Bay dose level was not significantly different for neonates). | Female | Adult | 6 adults/dose; 5-20 neonates/dose | Toxicity Factor Datasets | Laboratory |
Peregrine Falcon (Falco peregrinus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
MERCURY COMPOUNDS | review | concentrations in brain and liver associated with mortality (various avian species) | Not Reported | Not Reported | Not Reported | Toxicity Factor Datasets | Laboratory | |
MERCURY COMPOUNDS | review | concentrations in eggs associated with reduced reproduction (various avian species) | Not Reported | Not Reported | Not Reported | Toxicity Factor Datasets | Laboratory |
Pacific Treefrog (Pseudacris regilla formerly Hyla regilla)
Chemical | Endpoint Value | Endpoint Description | Units | Sex | Life Cycle Stage | Sample Size | Location | Type | Error | Lab |
---|---|---|---|---|---|---|---|---|---|---|
AMMONIUM CHLORIDE | 12.8 | NOAEL for body weight and length and deformities | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | Laboratory | ||
AMMONIUM SULFATE | 32.4 | 10-d LC50 for embryos | mg NH4-N/L | Not Reported | Embryo | 10/replicate; 3 replicates/dose | Toxicity Factor Datasets | 29.7 - 35.4 (95% CI) | Laboratory |
American Kestrel (Falco sparverius)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DICOFOL | non-detectable (@ 5 mg/kg), 560 ng/g (@ 20 mg/kg) | mean concentration of metabolite dichlorobenzophenone in eggs | Female | Adult | 10/group | Toxicity Factor Datasets | Laboratory | |
DICOFOL | increased @ 5 and 20 mg/kg | incidence of abnormal embyronic gonads | Both Male and Female | Embryo | 10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | decreased with PCB 153 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 126 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | no effect | chick mass and size at hatch, and chick survival to fledging versus controls | Both Male and Female | Adult, Juvenile | 15 pairs/treatment group; 10 control pairs | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decrease at all doses (45-59%) | red blood cell delta aminolevulinic acid dehydratase | Both Male and Female | Nestling | 10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 7.84 ppm femur at 120 ppm; 16.60 ppm femur at 212 ppm; 18.44 ppm femur at 448 ppm | mean lead concentration in femur | Both Male and Female | Adult | 8-14/group | Toxicity Factor Datasets | 1-2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at all doses (15.1-29.2%) | eggshell thickness | Female | Adult | 2-5 pairs/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | lead concentration in eggshell | Female | Adult | 16 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | decreased | bw (versus pre-study bw) | Female | Juvenile | 2 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
EPN | 68% (10.0 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 12 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
MIREX | 40.3% decrease @ 8 ppm | sperm concentration | Male | Adult | 5-10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DICOFOL | 8.11 (fat), 0.28 (liver) ug/g @ 0.3 mg/kg bw/d | sum of geometric mean tissue concentrations (wet wt) of dicofol and metabolites (dichlorobenzophenone, mono-dechlorinated dicofol, dichlorobenzhydrol, DDE) | Female | Adult | 2-4/group | Toxicity Factor Datasets | Laboratory |
Double-crested Cormorant (Phalacrocorax auritus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | 177 ug/kg egg (77-264) | LD50 (95% confidence limits) | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | 83-86 eggs/treatment | Lake Winnipegosis, Manitoba | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased at 400, 800 ug/kg egg | incidence of embryo mortality versus controls | Not Reported | Embryo | 15-60/group | Toxicity Factor Datasets | Laboratory |
Bullfrog (Lithobates catesbeianus formerly Rana catesbeiana)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
FENITROTHION | no effect | avoidance response assessed by daily prodding of newly hatched tadpoles | Not Reported | Embryo | 20 animals/replicate; 3 replicates/dose | Toxicity Factor Datasets | embryo; midneurulation stage | Laboratory |
Deer Mouse (Peromyscus maniculatus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
GLYPHOSATE | increased @ 1-80 mg/kg | thymus weight to bw ratio | Female | Adult | 12/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|
ALDICARB | no effect | daily activity measured as time spend in burrow or moving in/out of burrow | Female | 8 animals/dose | Toxicity Factor Datasets | 29 - 32 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | 1180 ppm diet (95% CL: 709-1485, slope = 1.88 +/- 0.57SE) | LD50 | Both Male and Female | Adult | 10 animals/dose | Toxicity Factor Datasets | Laboratory |
Clapper Rail (Rallus longirostris)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | 1896 ppm | 5 day dietary LC50 | Female | Juvenile | 4 birds | Toxicity Factor Datasets | Laboratory |
Mourning Dove (Zenaida macroura)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | mortality | Female | Adult | 25 birds/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | decreased at 10 ppm | percent of birds that laid eggs | Female | Adult | 10-13/group | Toxicity Factor Datasets | Laboratory |
California Ground Squirrel (Spermophilus beecheyi)
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|
STRYCHNINE | increase at 6.7-44.5 mg/kg bw | Both Male and Female | Not Reported | 3-5/group | Toxicity Factor Datasets | Laboratory |
Great Horned Owl (Bubo virginianus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
STRYCHNINE | increased | occurence (compared with pre-dose values) of uncoordinated movement, tremors, loss of perching ability and ability to stand on the ground | Not Reported | Adult | 1 bird | Toxicity Factor Datasets | Laboratory |
Song Sparrow (Melospiza melodia)
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries | Lab |
---|---|---|---|---|---|---|---|---|
DIMETHOATE | significant reduction of mean daily activity levels (perch hopping) | Not Reported | Not Reported | 7 treated; 7 control | Toxicity Factor Datasets | CANADA | Laboratory |