Mallard duck (Anas platyrhynchos)
Mallard duck (Anas platyrhynchos)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 200, 800 ppm | food consumption compared to controls | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory | |
NICKEL SULFATE | no effects | body wt, liver wt:brain wt, kidney wt:brain wt, duodenal wt compared to controls | Both Male and Female | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory | |
NICKEL SULFATE | no effects | plasma biochemistry compared to controls | Male | Adult | 6 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | 4.627 (@ 2 ppm), 54.333 (@ 20 ppm), 77.222 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in kidneys after 90 d of treatment | Both Male and Female | Adult | 20 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
CADMIUM CHLORIDE | increased to 0.010 (@ 20 ppm), 0.040 (@ 200 ppm) ppm, wet wt | Cd concentrations in eggs versus controls | Both Male and Female | Adult | 15 eggs (20 ppm), 3 eggs (200 ppm) | Toxicity Factor Datasets | 1 yr | Laboratory | |
CADMIUM CHLORIDE | increased @ 200 ppm/60 or 90 d of treatment, 30 d post-treatment | mean kidney weight versus controls | Both Male and Female | Adult | 10 kidneys/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | increased @ 3 ppm | incidence of brain lesions (demyelination, necrosis, neuronal shrinkage) | Not Reported | Juvenile | 3-11 ducklings/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | no effect | survival rate compared to controls | Not Reported | Juvenile | 25 birds/group | Toxicity Factor Datasets | 1 day | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | 25-27 (@ 30 ppm as Se-L-met or Se-DL-met), 13 (@ 30 ppm as yeast) ppm, wet wt | mean Se concentrations in liver | Not Reported | Juvenile | 25 birds/group | Toxicity Factor Datasets | 1 day | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 25 ppm | plasma uric acid concentration in hatchlings versus controls | Not Reported | Juvenile | 5-11 pairs/group | Toxicity Factor Datasets | Laboratory | |
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 5, 10, 25 ppm (as selenite), 10 ppm (as selenomethionine) | plasma glutathione peroxidase activity in hatchlings compared to controls | Not Reported | Juvenile | 5-11 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 2 ppm or greater | plasma glutathione peroxidase activity versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory | |
SELENOMETHIONINE | increased @ 16, 32 ppm | liver reduced gluthathione, oxidized glutathione, malondialdehyde concentrations versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
FENSULFOTHION | 0.528, 0.747, 1.06 (0.868-1.29), 0.747 (0.588-0.949) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory | |
PARATHION | 1.44 mg/kg | LD50 | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 7 days | Laboratory | |
ENDRIN | 22.3 (9.88-50.3), 3.37 (2.36-4.80), 2.90 (2.17-3.88), 5.33 (3.67-7.73) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory | |
PARATHION | 1.65 mg/kg | LD50 | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 30 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | increased in 2nd generation | proportion of eggs laid outside nestbox | Female | Adult | 14 pairs/group | Toxicity Factor Datasets | Laboratory | |
METHYLMERCURY DICYANDIAMIDE | no effect | hatchability and duckling survival versus controls | Not Reported | Juvenile | 14 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PENTACHLOROPHENOL | 12.2 +/- 2.3 ug/g lipid, 20.7 +/- 3.7 ug/g liver, 3.3 +/- 1.6 ug/g muscle, 2.6 +/- 1.5 ug/g brain at 423.2 ug/g diet | mean +/- SD tissue concentrations at the reported NOAEL (development) | Not Reported | Juvenile | 6-8 | Toxicity Factor Datasets | 4 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 32% decrease @ 40 mg/kg | Ca2+-Mg2+ ATPase activity in eggshell gland mucosa homogenates, compared to controls | Female | Adult | Not Reported | Toxicity Factor Datasets | 1 yr | Laboratory | |
DDE (4,4'-) | 44% increase @ 40 mg/kg | calcium content (umol/g dry weight) of eggshell gland mucosa, compared to controls | Female | Adult | Not Reported | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID | 2 ug/g @ control; 4 ug/g @ 100 ppm; 5 ug/g @ 400 ppm; 51 ug/g @ 1600 ppm | boron accumulation in brain (geometric mean; ug/g dry weight) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | Toxicity Factor Datasets | 1 d | Laboratory | |
BORIC ACID | decrease @ 400 and 1600 ppm | brain ATP (nmol/g) and protein (mg/g) concentrations | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
FUEL OILS | increase @ 2.5, 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 9-32/dose | Toxicity Factor Datasets | Laboratory | |
CRUDE OILS | increase @ 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 10-32/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BENZO[k]FLUORANTHENE | increase @ 0.2, 2.0 mg/kg egg | embryo mortality, compared to controls | Not Reported | Embryo | 20/dose | Toxicity Factor Datasets | 5 d of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | reduced above 6.2 mg/kg bw | body weight versus controls | Not Reported | Adult | 4-5 birds/dose | Toxicity Factor Datasets | Laboratory | |
PHOSPHORUS (YELLOW OR WHITE) | increased above 4.3 mg/kg bw | liver to body weight ratio versus controls | Not Reported | Adult | 4-5 birds/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | leukocyte counts, plasma biochemistry, corticosterone concentration versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | increased @ 250, 500 mg/kg bw | lymphocyte proliferation to PHA versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
EMAMECTIN BENZOATE | 570 ppm diet, 391-915 (95% CI) | dietary LC50 | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 10 days | Laboratory | |
EMAMECTIN BENZOATE | 20 ppm diet | no-observed-effect concentration (NOEC), based on reduced feed consumption and weight gain | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 10 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | no effect | onset of egg laying, eggshell thickness, frequency of embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | egg weight, hatching success, egg fertility versus controls | Both Male and Female | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | increased @ 414, 828 ug/g | occurrence of intranuclear inclusion bodies in kidneys versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 869 and 954 ug/g | incidence of renal tubular intranuclear inclusion bodies versus corn or complete diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 828 ug/g | occurrence of lead poisoning signs versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | 4.1(1.03) ppm in blood, 13(1.2) ppm in liver @ 954 ug/g, complete diet; 4.0(0.58) ppm in blood, 38(6.5) ppm in liver @ 869 ug/g, corn diet | mean (SE) wet wt Pb concentrations in blood and liver | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | 9.2(0.52) ppm with seleno-D,L-methionine; 8.9(0.35) ppm with seleno-L-methionine; 6.6(0.37) ppm with selenized yeast | mean(SE) wet wt concentrations of selenium in 8th egg laid | Female | Adult | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | no effect | incidence of illness versus controls | Both Male and Female | Adult | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | no effect | egg fertility, egg weight, eggshell thickness, and mean interval between laying of eggs versus controls | Both Male and Female | Adult | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | increased @ 10 ppm Hg, 10 ppm Se, 10 ppm Hg + 10 ppm Se | thiobarbituric acid-reactive substances in brain versus controls | Male | Adult | 12/treatment | Toxicity Factor Datasets | 18 mo | Laboratory | |
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | 3.4(0.22) ppm @ 10 ppm Se; 5.2(0.44) ppm @ 10 ppm Hg + 10 ppm Se | mean (SE) wet wt Se concentrations in brain | Male | Adult | 12/treatment | Toxicity Factor Datasets | 18 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | survival to 7 d, organ histopathology, hematocrit, sex ratios, kidney or liver weights of ducklings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | Toxicity Factor Datasets | 6-8 mo | Laboratory | |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | egg weight, eggshell thickness, fertility, hatchability versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | Toxicity Factor Datasets | 6-8 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | hemoglobin and hematocrit versus controls | Male | Juvenile | 8 | Laboratory | Toxicity Factor Datasets | 6 months | Laboratory |
LEAD (elemental) | decreased (60%) | blood ALAD activity versus controls | Male | Juvenile | 8 | Laboratory | Toxicity Factor Datasets | 6 months | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decreased | number of 14-day old ducklings per hen versus controls | Both Male and Female | Hatchling | 274-327, 69-167, and 26-113 for the 0, 10, and 40 ppm DDE groups | Toxicity Factor Datasets | Laboratory | |
DDE (4,4'-) | increased | % cracked eggs versus controls | Female | Hatchling | 666-696, 620-664, and 317-602 for the 0, 10, and 40 ppm DDE groups | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | no effect | total Ca/eggshell | Female | Adult | 5 hens; 19 eggs | Toxicity Factor Datasets | Laboratory | |
DDT (4,4'-) | no effect | Ca - ATPase activity in eggshell glands versus controls | Female | Adult | 5 hens; 19 eggs | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | adrenal wt, corticosterone concentrations versus controls | Male | Adult | 8 | Toxicity Factor Datasets | 32 weeks | Laboratory | |
CADMIUM CHLORIDE | no effect | liver Zn concentration versus controls | Male | Adult | 8 | Toxicity Factor Datasets | 32 weeks | Laboratory | |
CADMIUM CHLORIDE | increased @ 10, 50 ug/g diet | kidney Cd concentration versus controls | Male | Adult | 8 | Toxicity Factor Datasets | 32 weeks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | egg production, eggshell thickness and fertility, compared to control | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | Toxicity Factor Datasets | Laboratory | |
DIELDRIN | decrease | average % hatchability, compared to controls | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 49 - 163 | steady state bioconcentration factor for liver, calculated on a wet weight basis; range for 7 doses | Not Reported | Juvenile | 8-16/dose | Toxicity Factor Datasets | 1 d at initiation | Laboratory | |
DIELDRIN | 5.5 - 95 | steady state bioconcentration factor for muscle, calculated on a wet weight basis; range for 7 doses | Not Reported | Juvenile | 8-16/dose | Toxicity Factor Datasets | 1 d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 2 - 17% decrease @ 3-100 ug/g | eggshell thickness, compared to controls | Female | Adult | 5-10/dose | Toxicity Factor Datasets | Laboratory | |
DDE (4,4'-) | 10.3 (0.9 SE) ug/g wet wt. @ 3 ug/g diet; 91.5 (1.5 SE) @ 30 ug/g diet; 332.0 (26.0 SE) @ 100 ug/g diet | mean egg yolk concentrations after 37-42 d on DDE diet | Female | Adult | 5-10/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | body or liver weight at end of experiment | Female | Adult | 4/dose/sampling time | Toxicity Factor Datasets | 90 d at initiation | Laboratory | |
DDT (4,4'-) | no effect | body weight at end of experiment | Female | Adult | 4/dose/sampling time | Toxicity Factor Datasets | 80 d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PARAQUAT | 0.1 lbs AI/acre (slope = 2.10) for exposure of 3d embryo; 0.2 lbs AI/acre (slope = 3.29) for exposure of 8d embryo | LC50 | Not Reported | Embryo | 30/dose | Toxicity Factor Datasets | 3 or 8d of development | Laboratory | |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 66 lbs AI/acre for exposure of 3d embryo; 66 lbs AI/acre for exposure of 8d embryo | LC50 | Not Reported | Embryo | 30/dose | Toxicity Factor Datasets | 3 or 8d of development | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DICROTOPHOS | 0% @ 5 mg/L | percent mortality | Not Reported | Juvenile | 4-5/dose | Toxicity Factor Datasets | 2 weeks old | Laboratory | |
DICROTOPHOS | 70.1% @ 5 mg/L | brain acetylcholinesterase activity compared with controls | Not Reported | Juvenile | 4-5/dose | Toxicity Factor Datasets | 2 weeks old | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CHLORPYRIFOS | 644 ppm (declining to 141 ppm over 11 d) | 5 day dietary LC50, when 5 day residue half life was simulated | Not Reported | Juvenile | 10/group | Toxicity Factor Datasets | 14 d | Laboratory | |
CHLORPYRIFOS | decreased @ all doses | food consumption compared with controls | Not Reported | Juvenile | 10/group | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | increased when treatment initiated during early or late incub. | incidence of nest abandonment compared with controls | Female | Adult | 12 pairs/group | Toxicity Factor Datasets | 7 mo | Laboratory | |
METHYLPARATHION | no effect | number of hatchlings per nest, percent hatchability, hatchling survival and body weight to 5 days compared with controls | Not Reported | Hatchling | 12 pairs/group | Toxicity Factor Datasets | 7 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIAZINON, MALATHION, PARATHION | decreased @ all doses | brain or plasma cholinesterase activity in embryos or hatchlings compared to controls | Not Reported | Embryo, Hatchling | 12/group | Toxicity Factor Datasets | Day 3 of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
EPN | increased @ all doses | incidence of hyperactivity, ataxia, and/or paralysis compared with controls | Female | Juvenile | 6/group | Toxicity Factor Datasets | 20 wks | Laboratory | |
EPN | increased @ 30, 90, 270 ppm | incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls | Female | Juvenile | 6/group | Toxicity Factor Datasets | 20 wks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | 13.8% decrease | eggshell thickness, compared to controls | Female | Adult | 3/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
VANADYL SULFATE | brain, 9(1); fat, 20(11); kidney, 273(49); liver, 657(113), male femur 274(47); female femur 3327(2208) ppm, wet wt | mean (SE) vanadium concentrations @ 100 ppm dose in brain, fat, kidney, liver, and femur | Both Male and Female | Adult | 5 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
VANADYL SULFATE | <0.02 ppb, wet wt @ 1, 10 ppm; 63 ppb, wet wt @ 100 ppm | vanadium concentration in eggs | Female | Adult | 5 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased | erythrocyte protoporphyrin concentrations versus controls | Male | Adult | 20/treatment group | Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | no effect | body weight and hematocrit versus controls | Male | Juvenile | 20/treatment group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased @ 1 #four shot, 7, 14, 21 d. post-dose | agglutination titers to sheep red blood cells versus controls | Male | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CYANIDE | decreased @ 0.5,1,2 mg/kg bw | respiratory control ratios in heart, liver and brain versus controls | Female | Adult | at least 5 determinations/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
FUEL OILS | decreased @ 0.5, 5 ul/egg on incubation day 3 or 8 | embryo survival to day 18 of incubation and % of survivors that were normal versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory | |
FUEL OILS | decreased @ 0.5 ul/egg, incubation day 3 or 8 exposure | embyronic length and weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | decreased @ 1000 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | Toxicity Factor Datasets | Laboratory | |
CHLOROETHYLMERCURY | decreased @ 500 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE, COPPER COMPOUNDS, LEAD CHLORIDE | 56.7(7.7) @ 100 ppm Cd; 37.7 (3.7) @ 50 ppm Cd + 50 ppm Pb (ug/g, dry wt) | mean (SE) Cu concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | Toxicity Factor Datasets | 128 d (at initiation) | Laboratory | |
CADMIUM CHLORIDE, LEAD CHLORIDE, ZINC COMPOUNDS | 99 (6) @ 110 ppm Cd; 125 (7) @ 100 ppm Cd; 100 (5) @ 5 ppm Cd + 5 ppm Pb; 112 (2) @ 50 ppm Cd + 50 ppm Pb | mean (SE) Zn concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | Toxicity Factor Datasets | 128 d (at initiation) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | incidence of histopathological lesions, and liver, brain, and spleen weights | Both Male and Female | Juvenile | 30 birds/group | Toxicity Factor Datasets | Laboratory | |
ARSENATE, SODIUM | increased @ 300 ppm | plasma biochemistry changes versus controls | Both Male and Female | Juvenile | 30 birds/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.4 +/- 0.18 (@ 1 ppm, no DDE), 8.7 +/- 0.87 (@ 5 ppm, no DDE) ppm Hg, wet wt | mean Hg concentration in third egg laid in clutch (mean +/- SE) | Female | Adult | 10/group | Toxicity Factor Datasets | Laboratory | |
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.0 +/- 0.06 (@ 1 ppm Hg, no DDE), 5.3 +/- 0.56 (@ 5 ppm Hg, no DDE) ppm Hg, wet wt | Hg concentration in breast muscle (mean +/- SE) | Female | Adult | 10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | total body weight, compared to control | Not Reported | Juvenile | 4-6/dose | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | decrease @ 0.5% | body weight, average daily weight gain and tibiotarsus length, compared to controls | Not Reported | Juvenile | 8/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | no effect | body weight versus controls | Both Male and Female | Adult | 12/group | Toxicity Factor Datasets | 18 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 20.4% decrease | eggshell thickness versus controls | Female | Adult | 6 hens; 45 total eggs | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ACEPHATE | 51.7% (4.82 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | decreased | eggshell weight and thickness, total eggshell calcium and shell gland epithelial microsomal Ca-ATPase activity, compared to controls | Female | Adult | 5 hens/dose; 19 eggs/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
ENDRIN | breast muscle=non-detect.; liver=non-detect.-0.05; fat=non-detect.-0.50 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | 7-10 animals | Wenatchee | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | body weight and food consumption versus controls | Both Male and Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | Toxicity Factor Datasets | 6 mos | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 10,20,40 ppm | incidence of altered hepatic glutathione metabolism versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | day old | Laboratory |