Aquatic birds
Killdeer (Charadrius vociferus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
DDE (4,4'-) | no correlation with DDE residues in eggs | eggshell thickness | Female | Adult | 12 eggs | McHenry and Billings Counties | Toxicity Factor Datasets |
Double-crested Cormorant (Phalacrocorax auritus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | body and organ weights | Not Reported | Hatchling | 6-10 eggs/dose | Toxicity Factor Datasets | Laboratory | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | observed at 3, 10, 100 ug/kg | edema | Not Reported | Hatchling | 6-10 eggs/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased at 5 ug/kg egg | weights of heart, liver and spleen versus controls | Not Reported | Hatchling | 8-29/group | Toxicity Factor Datasets | Laboratory | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased at 4.0 ug/kg egg | incidence of embryo mortality versus controls | Not Reported | Hatchling | 58-60/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 0.06-0.11 (1972); 0.3 (1973) | fledging success (young/nest) in contaminated colonies | Not Reported | Embryo | 42 (1973)-66 (1972) nests | Lake Huron | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of embryonic deformities, depressed growth | Embryo, Juvenile | Not Reported | Toxicity Factor Datasets |
Mallard duck (Anas platyrhynchos)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | liver glycogen concentration versus controls | Male | Adult | 8 | Toxicity Factor Datasets | 32 weeks | Laboratory | |
CADMIUM CHLORIDE | no effect | % packed cell volume versus controls | Male | Adult | 8 | Toxicity Factor Datasets | 32 weeks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM, SELENOMETHIONINE | decreased | food consumption versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | Laboratory | |
SELENITE, SODIUM, SELENOMETHIONINE | decreased (liver decreased with selenite only) | bw and liver wt versus controls | Not Reported | Juvenile | 40 birds/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | hepatic microsomal enzyme activity (aniline hydroxylase and aminopyrine N-demethylase) | Female | Adult | 18/dose | Toxicity Factor Datasets | Laboratory | |
DDT (Technical Grade Mixture) | DDT <0.1, DDE 0.2 - 1.2 ug/g dry wt @ 0 ppm; DDT 0.3 - 4.2, DDE 1.0 - 12.7 @ 2 ppm; DDT 1.3 - 25.0, DDE 5.0 - 110.1 @ 20 ppm; DDT 25.5 - 254, DDE 58.0 - 1234 @ 200 ppm | DDT and DDE concentrations in egg dry matter ranging from 0-14 d to 330 - 343 d sampling periods at 4 dietary doses | Female | Adult | 18/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no differences | mean survival times compared among lead, iron and bismuth dosed birds | Both Male and Female | Adult | 5 males, 5 females per group | Toxicity Factor Datasets | 6-8 mo | Laboratory | |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no differences | mean body weight and organ weights compared among lead, iron and bismuth dosed birds | Both Male and Female | Adult | 5 males, 5 females per group | Toxicity Factor Datasets | 6-8 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | body weight at end of experiment | Not Reported | Juvenile | 12/dose | Toxicity Factor Datasets | 1 d at initiation | Laboratory | |
DIELDRIN | no effect | no mortality observed | Not Reported | Juvenile | 12/dose | Toxicity Factor Datasets | 1 d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DICOFOL | 5.4 (0.3 SE) ug/g wet wt. @ 3 ug/g diet; 18.1 (1.2 SE) @ 10 ug/g diet; 37.1 (1.6 SE) @ 30 ug/g diet; 150.7 (9.9SE) @ 100 ug/g diet, | mean egg yolk concentrations of p,p'-dicofol after 37-42 d on dicofol diet | Female | Adult | 4-8/dose | Toxicity Factor Datasets | Laboratory | |
DICOFOL | ST = 1.020 - 0.056C | regression equation relating shell thickness (mm) to log10 yolk concentration (C, ug/g); r2=0.39 | Female | Adult | 100 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (Technical Grade Mixture) | increase @ 200 ppm | Female | Adult | 18/dose | Toxicity Factor Datasets | Laboratory | ||
DDT (4,4'-) | decrease @ 20 - 200 ppm | eggshell thickness, weight and calcium concentration | Female | Adult | 18/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PARAQUAT | 1.5 lbs AI/acre (slope = 1.66) for exposure of 3d embryo; 2.5 lbs AI/acre (slope = 1.40) for exposure of 8d embryo | LC50 | Not Reported | Embryo | 30/dose | Toxicity Factor Datasets | 3 or 8d of development | Laboratory | |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 108 lbs AI/acre (slope = 1.62) for exposure of 3d embryo; 101 lbs AI/acre (slope = 3.06) for exposure of 8d embryo | LC50 | Not Reported | Embryo | 30/dose | Toxicity Factor Datasets | 3 or 8d of development | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PARATHION | 100% @ 5mg/L | percent mortality | Not Reported | Juvenile | 4-5/dose | Toxicity Factor Datasets | 2 weeks old | Laboratory | |
PARATHION | 0.8% @ 5 mg/L | brain acetylcholinesterase activity compared with controls | Not Reported | Juvenile | 4-5/dose | Toxicity Factor Datasets | 2 weeks old | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CHLORPYRIFOS | 357 ppm | 11 day dietary LC50 | Not Reported | Juvenile | 10/group | Toxicity Factor Datasets | 14 d | Laboratory | |
CHLORPYRIFOS | 236 ppm | 11 day dietary LC10 | Not Reported | Juvenile | 10/group | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries |
---|---|---|---|---|---|---|---|---|
CARBOFURAN | no effect | growth rate to four weeks of age compared with controls | Not Reported | Juvenile | 8/group | Toxicity Factor Datasets | CANADA |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DIAZINON | 9.7 (day 3), 11.1 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory | |
PARATHION | 2.2 (day 3), 1.5 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | Toxicity Factor Datasets | Day 3 or 8 of incubation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEPTOPHOS | 4/5 @ 260 ppm | incidence of CNS lesions | Both Male and Female | Juvenile | 3-5/group | Toxicity Factor Datasets | 14 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CRUDE OILS | 56% increase | hepatic cytochrome P450 content | Not Reported | Adult | 5/dose | Toxicity Factor Datasets | Laboratory | |
CRUDE OILS | no effect | body weight | Not Reported | Adult | 5/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 373 (95% CL; 152-574) ppm lipid basis @ 40 ppm diet | DDE residue concentrations in eggs | Female | Adult | 12 | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, DDE (4,4'-) | 344 (95% CL; 156-686) ppm DDE lipid basis and 346 (95%CL; 133-686) ppm PCB lipid basis @ 40 ppm DDE + 40 ppm PCB diet | mean DDE and PCB residue levels in eggs | Female | Adult | 13 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase @ 0.25 - 5.0% | plasma alanine aminotransferase activity, from liver | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 0-8 wks post-hatch | Laboratory | |
CRUDE OILS | increase @ 0.025 - 5% | pathological release of ornithine carbamyltransferase from kidney | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 0-8 wks post-hatch | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased @ > 60 ug/dl blood | delta-aminolevulinic acid dehydratase activity | Both Male and Female | Not Reported | 21 birds | World Wildlife Fund Refuge, Tuscany | Toxicity Factor Datasets | ITALY |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CYANIDE | no effect | ATP levels in heart versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory | |
CYANIDE | increased | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in brain versus controls | Female | Adult | 5/treatment | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased with lead shot (egg contents: 0.50 +/-0.06; egg shell: 2.80 +/-0.25 ppm, wet wt) and lead-iron shot (egg shell: 1.42 +/-0.26 ppm, wet wt) | lead in egg contents and shell (mean +/- SE) versus controls | Female | Adult | control=10 eggs; treatment=20 eggs | Toxicity Factor Datasets | 6 mos | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased with Pb/corn+Ca (50%), and Pb/corn only (100%) | % mortality versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 |
Toxicity Factor Datasets | Laboratory | |
LEAD (elemental) | decreased in Pb/commerical (hemoglobin only), Pb/corn+Ca, and Pb/corn only | red blood cell counts, packed cell volume, hemoglobin concentration versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 |
Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Countries |
---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | humerus, 41.652 (8.20-211.6); spleen, 0.669 (0.128-2.397); pancreas, 3.295 (1.074-13.47); brain, 1.367 (0.120-117.1) | geometric mean concentrations (ranges) in humerus, spleen, pancreas, and brain | Not Reported | Not Reported | 6-10 birds/tissue type | Ebro Delta Natural Park | Toxicity Factor Datasets | ITALY |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM, SELENOMETHIONINE | increased (100%) @ 60 ppm Se and (53%) @ 200 ppm As | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | increased in LL diets | incidence of clinical signs (LL vs. LH vs. NN diets) | Not Reported | Juvenile | 12-14/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | mortality versus controls | Both Male and Female | Adult | 20 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory | |
CADMIUM CHLORIDE | no effect | body wt, hematocrit, hemoglobin, food consumption versus controls | Both Male and Female | Adult | 20 pairs/group | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | decreased @ 0.5, 3 ppm | duration of egg production compared to controls | Female | Adult | 10 females, 3 males/dose | Toxicity Factor Datasets | Laboratory | |
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | hatching success and 1 wk survival of hatchlings compared to controls | Not Reported | Juvenile | 10 females, 3 males/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | 11-12 (@ 15 ppm as Se-met or wheat), 6.2 (@ 15 ppm as yeast), 19-20 (@ 30 ppm as Se-met or wheat), 9.9 (@ 30 ppm as yeast) ppm, wet wt | mean concentrations of Se in livers | Not Reported | Juvenile | 25 birds/group | Toxicity Factor Datasets | 1 day | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm (as Se-met or yeast) | food consumption compared to controls | Not Reported | Juvenile | 25 birds/group | Toxicity Factor Datasets | 1 day | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | decreased @ 8, 16 ppm | hatchability compared to controls | Not Reported | Juvenile | 5-11 pairs/group | Toxicity Factor Datasets | Laboratory | |
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 10,25 ppm (as selenite), 10 ppm (as selenomethionine) | number of embryos showing malformations or embryotoxicity compared to controls | Not Reported | Embryo | 5-11 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 32 ppm | plasma alkaline phosphatase activity and total protein levels versus controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory | |
SELENOMETHIONINE | decreased @ 32 ppm | body weight, liver DNA:RNA ratio, hematocrit compared to controls | Male | Adult | 10 birds/group | Toxicity Factor Datasets | 2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
MONOCROTOPHOS | 5.86 (4.70-7.29), 7.21 (5.79-8.98), 5.10 (4.44-5.86), 3.36 (2.77-4.09) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory | |
PARATHION | 1.65 mg/kg | LD50 | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hours | Laboratory | |
PROPOXUR | 7.38 (5.97-9.14), 12.7 (10.2-15.9), 14.6 (12.4-17.4), 9.58 (7.61-12.1) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | Toxicity Factor Datasets | 36 hr, 7 d, 30 d, or 6 mos | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | no effect | body weight versus controls | Both Male and Female | Adult | 14 pairs/group | Toxicity Factor Datasets | Laboratory | |
METHYLMERCURY DICYANDIAMIDE | increased in 2nd generation | food consumption versus controls | Both Male and Female | Adult | 14 pairs/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
PENTACHLOROPHENOL | decrease @ 961 ug/g | total body weight, compared to control; reported as the LOAEL for the study | Not Reported | Juvenile | 6/dose | Toxicity Factor Datasets | 4 d | Laboratory | |
PENTACHLOROPHENOL | no effect @ 423.2 ug/g | total body weight, compared to control; reported as the NOAEL for the study | Not Reported | Juvenile | 6/dose | Toxicity Factor Datasets | 4 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 25% decrease @ 40 mg/kg | calcium content of secreted fluid in the shell gland, compared to control | Female | Adult | 5/dose | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID | decrease @ 1600 ppm | hematocrit and hemoglobin concentration, compared to controls | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | Toxicity Factor Datasets | 1 d | Laboratory | |
BORIC ACID | increase @ 100, 400, 1600 ppm | plasma triglyceride concentration (21-42% increase, compared to controls) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | Toxicity Factor Datasets | 1 d | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
FUEL OILS | decrease @ 4.0, 7.0, 12.0 ml/kg/d | mean spleen index (spleen wt./body wt.) | Male | Adult | 4-5/dose | Toxicity Factor Datasets | Laboratory | |
COREXIT 9527 | no effect | % mortality, compared to controls | Male | Adult | 6/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease | egg hatchability (# eggs hatching/# fertile eggs), compared to controls | Female | Adult | 20 hens/dose | Toxicity Factor Datasets | Laboratory | |
DDE (4,4'-) | no effect | onset of laying, egg production, egg fertility and egg hatchability, compared to controls | Female | Adult | 20 hens/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | 3.90 mg/kg bw (3.24-4.69 95% CI) | 24 hour median lethal dose | Female | Adult | 4-5 birds/dose | Toxicity Factor Datasets | Laboratory | |
PHOSPHORUS (YELLOW OR WHITE) | reduced above 6.2 mg/kg bw | body weight versus controls | Not Reported | Adult | 4-5 birds/dose | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | decreased @ 20, 100, 250, 500 mg/kg bw | plasma triiodothyronine concentrations versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | no effect | leukocyte counts, plasma biochemistry, corticosterone concentration versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
EMAMECTIN BENZOATE | < 25 mg/kg bw | no-observed-effect level, based on body weight loss | Both Male and Female | Adult | 10/dose | Toxicity Factor Datasets | 19 weeks | Laboratory | |
EMAMECTIN BENZOATE | 570 ppm diet, 391-915 (95% CI) | dietary LC50 | Both Male and Female | Juvenile | 10/dose | Toxicity Factor Datasets | 10 days | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | hemoglobin concentrations versus controls | Male | Adult | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory | |
BORIC ACID, SELENOMETHIONINE | no effect | onset of egg laying, eggshell thickness, frequency of embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | reduced @ all doses | delta aminolevulinic acid dehydratase activity versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 869 ug/g, corn diet | mortality versus corn diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 414, 828 ug/g | occurrence of intranuclear inclusion bodies in kidneys versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | Toxicity Factor Datasets | approx. 5 mo | Laboratory | |
LEAD COMPOUNDS | increased @ 869 and 954 ug/g | incidence of renal tubular intranuclear inclusion bodies versus corn or complete diet controls | Male | Adult | 5/ Pb treatment;3/control treatments | Toxicity Factor Datasets | approx. 7 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | increased with seleno-D,L-methionine, seleno-L-methionine, or selenized yeast | incidence of embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory | |
SELENIUM COMPOUNDS, SELENOMETHIONINE | 9.2(0.52) ppm with seleno-D,L-methionine; 8.9(0.35) ppm with seleno-L-methionine; 6.6(0.37) ppm with selenized yeast | mean(SE) wet wt concentrations of selenium in 8th egg laid | Female | Adult | 15 pairs/treatment group, 10 pairs/control group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | reduced @ 10 ppm Hg, 10 ppm Hg + 10 ppm Se | protein-bound sulfhydryl in liver versus controls | Male | Adult | 12/treatment | Toxicity Factor Datasets | 18 mo | Laboratory | |
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | increased @ 10 ppm Hg, 10 ppm Se, 10 ppm Hg + 10 ppm Se | thiobarbituric acid-reactive substances in brain versus controls | Male | Adult | 12/treatment | Toxicity Factor Datasets | 18 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Bi | weight of hatchlings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | Toxicity Factor Datasets | 6-8 mo | Laboratory | |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | survival to 7 d, organ histopathology, hematocrit, sex ratios, kidney or liver weights of ducklings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | Toxicity Factor Datasets | 6-8 mo | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased (12-fold) | selenium concentrations in pectoral muscle | Male | Adult | Controls = 24 Treated = 8 |
Laboratory | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decreased | % normal hatchlings versus controls | Not Reported | Embryo | 492-518, 232-384, and 128-276 for the 0, 10, and 40 ppm DDE groups | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | no effect | calcium concentration in eggshell versus controls | Female | Adult | 5 hens; 19 eggs | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | no effect | number of eggs per incubated nest and percent fertility of eggs compared with controls | Both Male and Female | Adult | 12 pairs/group | Toxicity Factor Datasets | 7 mo | Laboratory |
Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|
see citation tables | LD50s for 42 compounds in aqueous and oil vehicles | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | incubation day 3-8 | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 7, 14, 21 d post-dose | concentration of lead in blood versus controls | Male | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | decreased @ 3,000, 30,000 ppm, incubation day 3 exposure | embyronic length and weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | Toxicity Factor Datasets | 3 or 8 days of incubation (time of treatment) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE, LEAD CHLORIDE | 7.2 (0.9) ug Pb/g @ 100 ppm Pb; 104.8 (19.1) ug Pb/g @ 100 ppm Cd; 54.2 (3.7) ug Cd/g @ 50 ppm Cd + 50 ppm Pb (dry wt) | mean (SE) concentrations in liver | Male | Juvenile | 6-8 birds/dose | Toxicity Factor Datasets | 128 d (at initiation) | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | survival rate versus controls | Both Male and Female | Juvenile | 30 birds/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
STEEL COMPOUNDS, TRIBUTYLTIN | increased in both groups (no treatment diffs) | white blood cell counts, monocyte counts, total protein concentrations over study period | Both Male and Female | Juvenile | 20/group | Toxicity Factor Datasets | 7 wks | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 18% decrease @ 40 mg/kg | eggshell index (shell weight/length x breadth), compared to control | Female | Adult | 18 | Toxicity Factor Datasets | 1 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | hemoglobin and hematocrit versus controls | Male | Juvenile | 8 | Laboratory | Toxicity Factor Datasets | 6 months | Laboratory |