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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIURON | 12.7 mg/l (95% CI; 9.8 - 16.4) | 21 d LC50 | Not Reported | Tadpole | 5/replicate; 3 replicates/dose | 0, 0.5, 1.0, 3.8, 7.6, 14.5, 21.1, 29.1 mg/l | TOX-MORT - toxicity benchmarks | 21 d | waterborne | Toxicity Factor Datasets |
DIURON | 7.6 mg/l | lowest NOAEL based on body weight endpoint | Not Reported | Tadpole | 5/replicate; 3 replicates/dose | 0, 0.5, 1.0, 3.8, 7.6, 14.5, 21.1, 29.1 mg/l | TOX-Non-Repro-Sublethal - whole animal | 21 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIURON | 22.2 mg/l (95% CI; 19.8 - 25.0) | 14 d LC50 | Not Reported | Tadpole | 5/replicate; 3 replicates/dose | 0, 0.5, 1.0, 3.8, 7.6, 14.5, 21.1, 29.1 mg/l | TOX-MORT - toxicity benchmarks | 14 d | waterborne | Toxicity Factor Datasets |
DIURON | 7.6 mg/l | lowest NOAEL based on body weight endpoint | Not Reported | Tadpole | 5/replicate; 3 replicates/dose | 0, 0.5, 1.0, 3.8, 7.6, 14.5, 21.1, 29.1 mg/l | TOX-Non-Repro-Sublethal - whole animal | 14 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
MALATHION | no effect | population size in sprayed areas, compared to control areas | Not Reported | Not Reported | Lexington, Dawson County | Not Reported | control or 0.585 liters/acre | TOX-POP - size effects | single application | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | decrease @ 6.7 kg/ha | population size | Not Reported | Not Reported | Exeter, Tulare | 38.7-54.2 mean squirrel population size range | 6.7 kg/ha; 13.5 ppm in stomach | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | increase @ 6.7 kg/ha | 5/6 radio-equipped coyotes were found dead during post-treatment period | Not Reported | Not Reported | Exeter, Tulare | 6 | 6.7 kg/ha; 13.5 ppm in stomach of squirrel | TOX-MORT - mortality in the field | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CESIUM COMPOUNDS | 0.24 (0.027 SE) Bq/g, wet weight (whole body) 0.30 (0.036 SE) Bq/g, wet weight (muscle) | whole body and muscle concentrations of 137Cesium | Both Male and Female | Both Adults and Juveniles | Par Pond reservoir system, Savannah River Site | 27 doves | 0.56 (0.065 SE) Bq/g, wet wt, ingesta | TOX-EXP IND - accumulation | NR | diet (via site contamination) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Units | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIMETHOATE | significant reduction of mean daily activity levels (perch hopping) | Not Reported | Not Reported | 7 treated; 7 control | average food intake 2.14 g (0.48SE)/d ; 0.24 g Dimethoate sprayed over 1 m2 seeds; | TOX-Non-Repro-Sublethal - behavioral effects | single; (1 seed lot0 | diet | Toxicity Factor Datasets | ||
DIMETHOATE | 3.4 | weight loss (3.4 g over experiment period; controls gained 0.43 g) | g | Not Reported | Not Reported | 7 treated; 7 control | 0.24 g Dimethoate sprayed over 1 m2 seeds | TOX-Non-Repro-Sublethal - indirect effects | single; (1 seed lot0 | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
HEXACHLOROETHANE | no effect | sister chromatid exchange counts, compared to controls | Not Reported | Not Reported | Goldstone, Fort Irwin | 3-4/group | control site and site 15 m from smoke source of fogoil and hexachloroethane | TOX-Non-Repro-Sublethal - genetic effects | 30 min. | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
IRON SULFATE | increase @ 30-288 mg/l | Not Reported | Juvenile | 5-25/dose | 0, 3, 10, 20, 30, 35, 40, 72, 144, 288 mg/l Fe++ | TOX-MORT - dose-response data | 39 d | waterborne | Toxicity Factor Datasets |
Endpoint Value | Toxicity Endpoint Type | Type |
---|---|---|
00 mg/kg | TOX-MORT - toxicity benchmarks | Toxicity Factor Datasets |
decrease @ 00 mg/kg | TOX-REPRO - reproductive success | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | body weight and delta-aminolevulinic acid dehydratase activity versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased | erythrocyte protoporphyrin concentrations versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight and hematocrit versus controls | Male | Juvenile | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | 60% @ 2 shot, 30% @ 4 shot | cumulative mortality | Male | Adult | 10/treatment group | 0, 2, or 4 #four lead shot | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 2 #four shot | mortality versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-MORT - dose-response data | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 931,000 shot/acre or 2 #four pellets | spleen weight and total white blood cell counts versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-Non-Repro-Sublethal - organ/system effects | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | ppm wet wt: 3.47 (1.38), blood; 32.16 (11.60), liver; 114.78 (28.96), femur @ 2 #four shot | mean (2SE) lead concentration in liver, femur and blood | Male | Adult | 11 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | ppm wet wt: 4.15 (3.56), blood; 13.85 (7.96), liver; 577.07 (156.4), femur@ 2 #four shot | mean (2SE) lead concentrations in liver, femur and blood | Female | Adult | 5 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | decreased @ 2 #four shot | spleen plaque forming cell counts, % packed cell volume versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 16 (2 #four shot) 63 (field exposure) | 0, 931,000 shot/acre or 2 # four shot | TOX-Non-Repro-Sublethal - organ/system effects | single (shot) 80 d (field exposure) | oral intubation (2 #four shot) ingestion (field exposure) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | serum glutamic pyruvic transaminase activity vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased with all treatments | incidence of hemosiderosis in liver vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | incidence of inclusion bodies in kidney vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | no effect | serum enzyme levels versus controls (at 30 or 60 d post dose) | Male | Adult | 2/group | 0, 8, 16, 32, 64 #four iron shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased @ > 60 ug/dl blood | delta-aminolevulinic acid dehydratase activity | Both Male and Female | Not Reported | World Wildlife Fund Refuge, Tuscany | 21 birds | 10-120 ug/dl blood (mean 46 +/- 25 sd) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination (primary uptake via ingestion) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 7, 14, 21 d post-dose | concentration of lead in blood versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased @ 1 #four shot | mortality rate by 15 d post-dose versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 1 #four shot, 7, 14, 21 d. post-dose | agglutination titers to sheep red blood cells versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ENDRIN | breast muscle=non-detect.; liver=non-detect.-0.05; fat=non-detect.-0.50 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | Wenatchee | 7-10 animals | 1.3-1.7 kg/ha | TOX-EXP IND - accumulation | NR | pesticide application (late fall) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | no effect (3 or 8 d) | open field behavior scores versus controls | Not Reported | Juvenile | 26-28/group | 0,5,50,500 ppm lead as lead nitrate | TOX-Non-Repro-Sublethal - behavioral effects | 3 or 8 d | diet | Toxicity Factor Datasets |
LEAD NITRATE | decreased @ 5 ppm (8 d exposure) | mean percentage weight gain versus controls | Not Reported | Juvenile | 26-28/group | 0,5,50,500 ppm lead as lead nitrate | TOX-REPRO - development | 3 or 8 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 12 ug/g (82%); 36 ug/g (77%); 108 ug/g (70%) | percent survival versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-MORT - dose-response data | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36, 108 ug/g | brain weight, acetylcholinesterase activity, neurotoxic esterase activity versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 108 ug/g | brain protein content versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ENDRIN | breast muscle=0.02 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | Wenatchee | 1 animal | 1.3-1.7 kg/ha | TOX-EXP IND - accumulation | NR | pesticide application (late fall) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ENDRIN | brain=greater than or equal to 0.8 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | Wenatchee | 1-3 animals | 1.3-1.7 kg/ha | TOX-EXP IND - accumulation | NR | pesticide application (late fall) | Toxicity Factor Datasets |