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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CARBOFURAN | increased at 63.4, 126.8, 253.6 ppm | mortality versus controls | Both Male and Female | Adult | 8 | 0,31.7,63.4,126.8,253.6 ppm in diet | TOX-MORT - dose-response data | 1 d | diet | Toxicity Factor Datasets |
FENTHION | decreased to 10% of control levels | brain cholinesterase activity of birds that died | Both Male and Female | Adult | 8 | 0,23.6,47.2,94.5,189.0 ppm in diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1 d | diet | Toxicity Factor Datasets |
CARBOFURAN | decreased to 35% of controls | brain cholinesterase activity in birds that died | Both Male and Female | Adult | 8 | 0,31.7,63.4,126.8,253.6 ppm in diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | Y=1.132 + 0.801X (R^2 = 0.932) | relationship between Se concentrations in diet and blood | Both Male and Female | Adult | 9-10 pairs/group | 0,5,9 ppm, dry wt, in diet | TOX-EXP IND - accumulation | 77 d | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS | 7.5 ppm Se, dry wt | maximum observed Se concentration in blood | Both Male and Female | Adult | 10 pairs/group | 8 ppm, dry wt, in contaminated prey species | TOX-EXP IND - accumulation | 77 d | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | incidence of mortality or signs of toxicity | Both Male and Female | Adult | 9-10 pairs/group | 0,5,9 ppm, dry wt, in diet | TOX-MORT - dose-response data | 77 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DICOFOL | decreased 5.45% (@ 5 mg/kg), 10.98% (@ 20 mg/kg) | eggshell thickness compared to controls | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - physiology | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | non-detectable (@ 5 mg/kg), 560 ng/g (@ 20 mg/kg) | mean concentration of metabolite dichlorobenzophenone in eggs | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-EXP IND - accumulation | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | increased @ 5 and 20 mg/kg | incidence of abnormal embyronic gonads | Both Male and Female | Embryo | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - development | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | increased @ 5 mg/kg | numbers of chicks or eggs lost (destroyed) by breeding male and female offspring of dicofol-treated females versus controls | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - development | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | no effect | eggshell thickness for breeding female offspring of dicofol-treated females versus controls | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - physiology | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | increased @ 5 mg/kg bw | incidence of abnormal gonads in male offspring of dicofol-treated females versus controls | Male | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - development | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DICOFOL | increased | incidence of abnormal behavior in adult offspring of treated females | Both Male and Female | Adult | 10 pairs/group | 0,5,20 mg/kg bw | TOX-REPRO - behavior | daily, throughout the breeding season | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | decreased @ 250, 1000 ng/g bw | body and organ growth versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - whole animal | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 50,250,1000 ng/g bw | incidence and severity of lesions in liver, spleen, bursa, thyroid versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased | plasma enzyme activities indicative of hepatotoxicity versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | hematocrit and hemoglobin values versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 50,250,1000 ng/g bw | hepatic monooxygenase activities versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | in ng/g, wet wt: 156 (@ 50 ng/g), 380 (@ 250 ng/g), 1098 (@1000 ng/g) | concentration in liver | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | positive correlation | relationship between hepatic PCB 126 concentrations and ratio of oxidized to reduced glutathione | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | reduced @ 233 ng/g | percent hatching success, percent pipped versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-MORT - dose-response data | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | reduced @ 233 ng/g | liver weight, radius and femur length versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 2.3, 23, 233 ng/g | incidence of malformations or edema, and EROD activity versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | reduced @ 100, 1000 ng/g | percent hatching success, percent pipped versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-MORT - dose-response data | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | reduced @ 1000 ng/g | humerus length versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased @ 100, 1000 ng/g | incidence of malformations or edema, and EROD activity versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver weight (as percent of body weight) versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with Aroclor 1254 | coproporphyrin levels in liver versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | decreased with PCB 153 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 126 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | increased after 4 or 12 weeks | aminopyrine N-demethylase and aldrin epoxidase activities versus controls | Female | Adult | 4/treatment group | 0, 7 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | daily for 4, 8 or 12 weeks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | decreased after 4 weeks | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0, 7 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | daily for 4, 8 or 12 weeks | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | blood Se concentration = 1.307 + 0.852(diet Se concentration) | relation between Se concentrations in blood (dry wt) and diet (dry wt) | Male | Adult | 40 birds | 0,6, 12 ppm, dry wt, Se in diet | TOX-EXP IND - accumulation | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | egg Se concentration = 1.307 + 0.852(diet Se concentration) | relation between Se concentrations in egg (dry wt) and diet (dry wt) | Female | Adult | 53 eggs | 0,6, 12 ppm, dry wt, Se in diet | TOX-EXP IND - accumulation | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 6 or 12 ppm Se | food consumption versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-Non-Repro-Sublethal - behavioral effects | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | percent of pairs that laid eggs, number of fertile pairs and egg hatchability versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - reproductive success | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | egg mass, width, length, and volume versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - physiology | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | reduced @ 12 ppm Se | ratio of # fertile eggs to total # eggs laid versus 6 ppm Se group | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - reproductive success | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | incidence of embryo deformities versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - development | 11 wks | diet | Toxicity Factor Datasets |