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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | body weight and delta-aminolevulinic acid dehydratase activity versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased | erythrocyte protoporphyrin concentrations versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight and hematocrit versus controls | Male | Juvenile | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | 60% @ 2 shot, 30% @ 4 shot | cumulative mortality | Male | Adult | 10/treatment group | 0, 2, or 4 #four lead shot | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 2 #four shot | mortality versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-MORT - dose-response data | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 931,000 shot/acre or 2 #four pellets | spleen weight and total white blood cell counts versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-Non-Repro-Sublethal - organ/system effects | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | ppm wet wt: 3.47 (1.38), blood; 32.16 (11.60), liver; 114.78 (28.96), femur @ 2 #four shot | mean (2SE) lead concentration in liver, femur and blood | Male | Adult | 11 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | ppm wet wt: 4.15 (3.56), blood; 13.85 (7.96), liver; 577.07 (156.4), femur@ 2 #four shot | mean (2SE) lead concentrations in liver, femur and blood | Female | Adult | 5 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | decreased @ 2 #four shot | spleen plaque forming cell counts, % packed cell volume versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 16 (2 #four shot) 63 (field exposure) | 0, 931,000 shot/acre or 2 # four shot | TOX-Non-Repro-Sublethal - organ/system effects | single (shot) 80 d (field exposure) | oral intubation (2 #four shot) ingestion (field exposure) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | serum glutamic pyruvic transaminase activity vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased with all treatments | incidence of hemosiderosis in liver vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | incidence of inclusion bodies in kidney vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | no effect | serum enzyme levels versus controls (at 30 or 60 d post dose) | Male | Adult | 2/group | 0, 8, 16, 32, 64 #four iron shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased @ > 60 ug/dl blood | delta-aminolevulinic acid dehydratase activity | Both Male and Female | Not Reported | World Wildlife Fund Refuge, Tuscany | 21 birds | 10-120 ug/dl blood (mean 46 +/- 25 sd) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination (primary uptake via ingestion) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 7, 14, 21 d post-dose | concentration of lead in blood versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased @ 1 #four shot | mortality rate by 15 d post-dose versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 1 #four shot, 7, 14, 21 d. post-dose | agglutination titers to sheep red blood cells versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ENDRIN | breast muscle=non-detect.; liver=non-detect.-0.05; fat=non-detect.-0.50 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | Wenatchee | 7-10 animals | 1.3-1.7 kg/ha | TOX-EXP IND - accumulation | NR | pesticide application (late fall) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | no effect (3 or 8 d) | open field behavior scores versus controls | Not Reported | Juvenile | 26-28/group | 0,5,50,500 ppm lead as lead nitrate | TOX-Non-Repro-Sublethal - behavioral effects | 3 or 8 d | diet | Toxicity Factor Datasets |
LEAD NITRATE | decreased @ 5 ppm (8 d exposure) | mean percentage weight gain versus controls | Not Reported | Juvenile | 26-28/group | 0,5,50,500 ppm lead as lead nitrate | TOX-REPRO - development | 3 or 8 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 12 ug/g (82%); 36 ug/g (77%); 108 ug/g (70%) | percent survival versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-MORT - dose-response data | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36, 108 ug/g | brain weight, acetylcholinesterase activity, neurotoxic esterase activity versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 108 ug/g | brain protein content versus controls | Not Reported | Embryo | 10/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 36 (cholineserase only), 108 ug/g | plasma alkaline phosphatase, aspartate aminotransferase, cholinesterase activities, and uric acid | Not Reported | Embryo | 12/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36, 108 ug/g | embryo weight and length, % normal survivors versus controls | Not Reported | Embryo | 12/group | 0,12,36,108 ug/g egg | TOX-REPRO - development | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12 ug/g (48%), 36 ug/g (29%), 108 ug/g (0%) | % surviving to hatch versus controls | Not Reported | Hatchling | 12/group | 0,12,36,108 ug/g egg | TOX-MORT - dose-response data | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36 ug/g | plasma cholinesterase activity, hemoglobin and uric acid content | Not Reported | Hatchling | 12/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CYANIDE | decreased @ all doses | ATP levels in liver and brain tissues versus controls | Female | Adult | 5/treatment | 0,0.25,0.5,1.0,2.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | no effect | ATP levels in heart versus controls | Female | Adult | 5/treatment | 0,0.25,0.5,1.0,2.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | increased | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in brain versus controls | Female | Adult | 5/treatment | 0,1.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | no effect | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in liver and heart versus controls | Female | Adult | 5/treatment | 0,1.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CYANIDE | increased @ 1, 2 mg/kg bw | serum creatine kinase activity versus controls | Female | Adult | at least 5 determinations/group | 0,1,2 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | decreased @ 0.5,1,2 mg/kg bw | respiratory control ratios in heart, liver and brain versus controls | Female | Adult | at least 5 determinations/group | 0,0.5,1,2 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | body weight and food consumption versus controls | Both Male and Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-Non-Repro-Sublethal - whole animal | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | incidence of lead poisoning tissue lesions versus controls | Both Male and Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-Non-Repro-Sublethal - organ/system effects | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 112.27 (+/- 44.27); lead-iron: 32.65 (+/- 16.58) ppm, wet wt | lead concentration in bone (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 10.22 (+/- 1.46); lead-iron: 3.38 (+/- 0.56) ppm, wet wt | lead concentration in bone (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 0.71 (+/- 0.25); lead-iron: 0.31 (+/- 0.06) ppm, wet wt | lead concentration in blood (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 0.49 (+/-0.10); lead-iron: 0.23 (+/- 0.04) ppm, wet wt | lead concentration in blood (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |