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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | decreased @ 450 ppm | body and liver weights compared to controls | Not Reported | Adult | 12 birds/group | 0,50,150,450 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 42 (+/-1) d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 150, 450 ppm | kidney and adrenal weights compared to controls | Not Reported | Adult | 12 birds/group | 0,50,150,450 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 42 (+/-1) d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 450 ppm | plasma uric acid, adrenal corticosterone levels | Not Reported | Adult | 12 birds/group | 0,50,150,450 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 42 (+/-1) d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | food consumption compared to controls | Not Reported | Adult | 12 birds/group | 0,50,150,450 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 42 (+/-1) d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | decreased @ 450 ppm | liver aldolase activity, plasma triiodothyronine levels | Not Reported | Adult | 12 birds/group | 0,50,150,450 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 42 (+/-1) d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | decreased @ 20 ppm | packed cell volume and hemoglobin concentration by 8 wks of treatment compared to controls | Not Reported | Juvenile | day old | 12 birds per timexdose treatment | 0,5,10,20 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4,8,12 wks | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 20 ppm | incidence of kidney lesions by 12 wks of treatment compared to controls | Not Reported | Juvenile | day old | 12 birds per timexdose treatment | 0,5,10,20 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 4,8,12 wks | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 20 ppm | serum glutamic pyruvic transaminase activity by 8 wks of treatment compared to controls | Not Reported | Juvenile | day old | 12 birds per timexdose treatment | 0,5,10,20 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4,8,12 wks | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 0.10 (@ 0 ppm), 10.13 (@ 5 ppm), 16.25 (@ 10 ppm), 42.21 (@ 20 ppm) ppm, wet wt | mean Cd concentrations in liver by 12 wks of treatment | Not Reported | Juvenile | day old | 12 birds per timexdose treatment | 0,5,10,20 ppm diet | TOX-EXP IND - accumulation | 4,8,12 wks | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | body weight, liver weight, and femur density compared to controls | Not Reported | Juvenile | day old | 12 birds per timexdose treatment | 0,5,10,20 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 4,8,12 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 32 ppm | incidence of liver histopathological lesions, liver:body wt ratios versus controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 32 ppm | plasma alkaline phosphatase activity and total protein levels versus controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 32 ppm | body weight, liver DNA:RNA ratio, hematocrit compared to controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 16, 32 ppm | hemoglobin concentration compared to controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 2 ppm or greater | plasma glutathione peroxidase activity versus controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 16, 32 ppm | liver reduced gluthathione, oxidized glutathione, malondialdehyde concentrations versus controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 14 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 2 ppm or greater | Se concentrations in liver versus controls | Male | Adult | 10 birds/group | 0.2,1,2,4,8,16,32 ppm diet | TOX-EXP IND - accumulation | 14 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | decreased @ 60 ppm Se (47% mort.) | survival versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 22% protein in the diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 60 ppm Se | body, liver, and spleen weight; tarsus length versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 22% protein in the diet) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 60 ppm Se (100% mort.) | survival versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 7% protein in the diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 15 ppm Se | body, liver, and spleen weight; tarsus length versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 7% protein in the diet) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | increased @ 15, 60 ppm Se (with and w/out B), 1000 ppm B | incidence of plasma chemistry changes versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 22% protein in the diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | increased @ 15 ppm Se (with and w/out B), 1000 ppm B | incidence of plasma chemistry changes versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 7% protein in the diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 1000 ppm B | hematocrits and hemoglobin concentrations versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm Bo, 15 ppm Se + 1000 ppm Bo, 60 ppm Se + 1000 ppm Bo (all treatments were conducted with 22% protein in the diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 15 ppm Se (with or w/out B), and 1000 ppm B | hematocrits and hemoglobin concentrations versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 7% protein in the diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | 10.8 (@ 15 ppm Se), 56.0 (@ 60 ppm) ppm Se, wet wt 11.0 (@ 1000 ppm B) ppm B, wet wt | geometric mean Se and B concentrations in liver | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 22% protein in the diet) | TOX-EXP IND - accumulation | 4 wks | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | 22.5 (@ 15 ppm Se w/out B), 41.9 (@ 15 ppm Se w/B) ppm Se, wet wt 13.0 (@ 1000 ppm B) ppm B, wet wt | geometric mean Se and B concentrations in liver | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 1000 ppm B, 15 ppm Se + 1000 ppm B, 60 ppm Se + 1000 ppm B (all treatments were conducted with 7% protein in the diet) | TOX-EXP IND - accumulation | 4 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MONOCROTOPHOS | 5.86 (4.70-7.29), 7.21 (5.79-8.98), 5.10 (4.44-5.86), 3.36 (2.77-4.09) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
PROPOXUR | 7.38 (5.97-9.14), 12.7 (10.2-15.9), 14.6 (12.4-17.4), 9.58 (7.61-12.1) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
DICROTOPHOS | 6.17 (3.33-11.4), 7.03 (5.30-9.31), 6.73 (5.53-8.19), 4.14 (3.33-5.16) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
FENSULFOTHION | 0.528, 0.747, 1.06 (0.868-1.29), 0.747 (0.588-0.949) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ENDRIN | 22.3 (9.88-50.3), 3.37 (2.36-4.80), 2.90 (2.17-3.88), 5.33 (3.67-7.73) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
CARBOFURAN | 0.370 (0.283-0.484), 0.628 (0.530-0.744), 0.510 (0.410-0.635), 0.415 (0.333-0.516) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
DEMETON | 13.3 (11.0-16.2), 15.3 (12.9-18.1), 15.1 (12.0-19.0), 8.19 (6.58-10.2) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 130 (80.4-210), 30.8 (23.3-40.6), 70.7 (37.6-133) | LD50's determined at ages 36 hr, 7 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
MEXACARBATE | 3.16 (2.17-4.61), 4.11 (2.70-6.26), 3.61 (2.37-5.49), 3.23 (2.72-3.85), 2.72(2.28-3.23) | LD50's determined at ages 48 hr, 7 d, 14 d, 30 d and 60 d, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
SODIUM MONOFLUOROACETATE | 9.78 (6.31-15.2), 3.71 (2.50-5.48), 3.71, 4.81 (2.57-8.99) | LD50's determined at ages 36 hr, 7 d, 30 d, and 6 mos, respectively (95% CI in parenth.) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | hematocrit and hemoglobin | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 100 ppm ( 0.4 ppm, dry wt), 300 ppm (0.8 ppm, dry wt) | accumulation of arsenic in brain tissue (geometric means in parentheses) | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 12, 36 ug/g | brain weight, protein content, acetylcholinesterase and neurotoxic esterase versus controls | Not Reported | Hatchling | 12/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |