Species
Filter by Species
Filter by Toxicity Endpoint Type
Filter by Exposure Endpoint Type
Filter by Chemical
Filter by Location
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | increased @ 10 ppm Hg, 10 ppm Se, 10 ppm Hg + 10 ppm Se | thiobarbituric acid-reactive substances in brain versus controls | Male | Adult | 12/treatment | 0, 10 ppm Hg, 10 ppm Se, 10 ppm Hg plus 10 ppm Se in diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | April 1-June 16 | diet | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | 3.4(0.22) ppm @ 10 ppm Se; 5.2(0.44) ppm @ 10 ppm Hg + 10 ppm Se | mean (SE) wet wt Se concentrations in brain | Male | Adult | 12/treatment | 0, 10 ppm Hg, 10 ppm Se, 10 ppm Hg plus 10 ppm Se in diet | TOX-EXP IND - accumulation | April 1-June 16 | diet | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE, SELENOMETHIONINE | 17.9(1.06) ppm @ 10 ppm Hg; 14.1(0.74) ppm @ 10 ppm Hg + 10 ppm Se | mean (SE) wet wt Hg concentrations in brain | Male | Adult | 12/treatment | 0, 10 ppm Hg, 10 ppm Se, 10 ppm Hg plus 10 ppm Se in diet | TOX-EXP IND - accumulation | April 1-June 16 | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS | no effect | mortality versus controls | Both Male and Female | Adult | 20 males, 20 females per group | 0, six #4 iron or bismuth shot; see paper for retention and dissolution of shot in gizzards of treated birds | TOX-MORT - dose-response data | 30 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS | no effect | body weight, organ weights (liver, kidney, gonads, gizzard) or hematocrit versus controls | Both Male and Female | Adult | 20 males, 20 females per group | 0, six #4 iron or bismuth shot; see paper for retention and dissolution of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - whole animal | 30 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS | 6.86(0.99) ppm, kidneys; 2.23(0.492) ppm, liver; 0.468(0.277) ppm, gonads | mean(SE) wet wt Bi concentration in organs of Bi-treated birds | Both Male and Female | Adult | 20 males, 20 females per group | 0, six #4 iron or bismuth shot; see paper for retention and dissolution of shot in gizzards of treated birds | TOX-EXP IND - accumulation | 30 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS | 145(6.0) ppm, kidneys; 1086(72) ppm, liver; 32.1(6.3) ppm, gonads | mean(SE) wet wt Fe concentration in organs of Fe-treated birds | Both Male and Female | Adult | 20 males, 20 females per group | 0, six #4 iron or bismuth shot; see paper for retention and dissolution of shot in gizzards of treated birds | TOX-EXP IND - accumulation | 30 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS | no effect | histopathological lesions in gonads, liver, kidneys versus controls | Both Male and Female | Adult | 20 males, 20 females per group | 0, six #4 iron or bismuth shot; see paper for retention and dissolution of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 30 d | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Pb, no effect with Fe or Bi | mortality versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-MORT - dose-response data | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Pb; no effect with Fe or Bi | body weight, gonad weight, hematocrit versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - whole animal | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Pb; no effect with Fe or Bi | gizzard and kidney weight versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - organ/system effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Pb | liver weight versus controls (females only) | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - organ/system effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | onset of lay and time to lay 21 eggs versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Fe | weight of eggs that hatched versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Bi | weight of eggs that did not hatch versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Bi | weight of hatchlings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | survival to 7 d, organ histopathology, hematocrit, sex ratios, kidney or liver weights of ducklings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | egg weight, eggshell thickness, fertility, hatchability versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | histopathology of kidney, liver, testis, heart, lung versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - cellular/biochemical effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 213(27.1) ppm, kidney; 91(4.55) ppm, liver; 9.8(3.22) ppm, ovary; 3.49(0.61) ppm, testis | mean(SE) wet wt concentrations of Pb in Pb-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 237(17.2) ppm, kidney; 1936(233) ppm, liver; 90.6(6.85) ppm, ovary; 13.1(1.29) ppm, testis | mean(SE) wet wt concentrations of Fe in Fe-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 1.54(0.280) ppm, kidney; 0.637(0.134) ppm, liver; 0.042(0.007) ppm, ovary; 0.098(0.042) ppm, testis | mean(SE) wet wt concentrations of Bi in Bi-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | blood ALAD enzyme activity after 1,2, or 3 months versus pre-dose controls | Both Male and Female | Adult | laboratory | 20 per sex | 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single exposure | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased | blood Pb concentrations versus pre-dose controls | Both Male and Female | Adult | laboratory | 20 per sex | 1 lead shot (no. 4) | TOX-EXP IND - accumulation | single exposure | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CYANOFENPHOS | increased | incidence of delayed neurotoxicity signs | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased (30% @ 10 mg leptophos/kg/d; 10% @ 0.5 mg cyanofenphos/kg/d; 0% @ 1.0 mg cyanofenphos/kg/d; 20% @ 2.0 mg cyanofenphos/kg/d ;60% @ 4.0 mg cyanofenphos/kg/d; 100% @ 8.0 mg cyanofenphos/kg/d | mortality versus controls) | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-MORT - dose-response data | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | decreased @ 2.0, 4.0 mg/kg/d | bw versus controls | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased @ 2.0, or 4.0 mg cyanofen/kg/d, 10 mg leptophos/kg/d. | incidence of histological lesions in axons and myelin sheaths | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | 90 days | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | decreased | incidence of delayed hypersensitivity reactions to antigen versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 2.2 mg Se/L | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | decreased | blood monocyte counts after 78 days exposure versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 0.5, 3.5 mg Se/L (sodium selenite); 2.2 mg Se/L (selenomethionine) | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
Endpoint Value | Endpoint Description | Toxicity Endpoint Type | Type |
---|---|---|---|
0.99(0.050) ppm @ 103 ug/g Pb; 1.7(0.18) ppm @ 207 ug/g Pb; 2.9(0.27) ppm @ 414 ug/g Pb; 6.1(0.97) ppm @ 828 ug/g Pb | mean(SE) wet wt concentrations of lead in blood at 10 wks post-dose | TOX-EXP IND - accumulation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Toxicity Endpoint Type | Type |
---|---|---|---|
DIELDRIN | review | TOX-MORT - dose-response data | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | blood Se concentration = 1.307 + 0.852(diet Se concentration) | relation between Se concentrations in blood (dry wt) and diet (dry wt) | Male | Adult | 40 birds | 0,6, 12 ppm, dry wt, Se in diet | TOX-EXP IND - accumulation | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | egg Se concentration = 1.307 + 0.852(diet Se concentration) | relation between Se concentrations in egg (dry wt) and diet (dry wt) | Female | Adult | 53 eggs | 0,6, 12 ppm, dry wt, Se in diet | TOX-EXP IND - accumulation | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 6 or 12 ppm Se | food consumption versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-Non-Repro-Sublethal - behavioral effects | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | percent of pairs that laid eggs, number of fertile pairs and egg hatchability versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - reproductive success | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | egg mass, width, length, and volume versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - physiology | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | reduced @ 12 ppm Se | ratio of # fertile eggs to total # eggs laid versus 6 ppm Se group | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - reproductive success | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | incidence of embryo deformities versus controls | Both Male and Female | Adult | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - development | 11 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | no effect | chick mass and size at hatch, and chick survival to fledging versus controls | Both Male and Female | Adult, Juvenile | 15 pairs/treatment group; 10 control pairs | 0,6, 12 ppm, dry wt, Se in diet | TOX-REPRO - development | 11 wks | diet | Toxicity Factor Datasets |