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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DICOFOL | increased @ 5 mg/kg | numbers of chicks or eggs lost (destroyed) by breeding male and female offspring of dicofol-treated females versus controls | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - development | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | no effect | eggshell thickness for breeding female offspring of dicofol-treated females versus controls | Female | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - physiology | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
DICOFOL | increased @ 5 mg/kg bw | incidence of abnormal gonads in male offspring of dicofol-treated females versus controls | Male | Adult | 10/group | 0,5,20 mg/kg bw | TOX-REPRO - development | daily, throughout breeding season | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DICOFOL | increased | incidence of abnormal behavior in adult offspring of treated females | Both Male and Female | Adult | 10 pairs/group | 0,5,20 mg/kg bw | TOX-REPRO - behavior | daily, throughout the breeding season | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | decreased @ 250, 1000 ng/g bw | body and organ growth versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - whole animal | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 50,250,1000 ng/g bw | incidence and severity of lesions in liver, spleen, bursa, thyroid versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased | plasma enzyme activities indicative of hepatotoxicity versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | hematocrit and hemoglobin values versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 50,250,1000 ng/g bw | hepatic monooxygenase activities versus controls | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | in ng/g, wet wt: 156 (@ 50 ng/g), 380 (@ 250 ng/g), 1098 (@1000 ng/g) | concentration in liver | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | positive correlation | relationship between hepatic PCB 126 concentrations and ratio of oxidized to reduced glutathione | Not Reported | Nestling | 9-11/group | 0,50,250,1000 g/ng bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | reduced @ 233 ng/g | percent hatching success, percent pipped versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-MORT - dose-response data | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | reduced @ 233 ng/g | liver weight, radius and femur length versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 2.3, 23, 233 ng/g | incidence of malformations or edema, and EROD activity versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 0.23, 2.3, 23, 233 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | reduced @ 100, 1000 ng/g | percent hatching success, percent pipped versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-MORT - dose-response data | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | reduced @ 1000 ng/g | humerus length versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased @ 100, 1000 ng/g | incidence of malformations or edema, and EROD activity versus controls | Not Reported | Hatchling | 24-26/treatment group | 0, 100, 1000 ng/g egg weight | TOX-REPRO - development | single dose at incubation day 6 | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver weight (as percent of body weight) versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with Aroclor 1254 | coproporphyrin levels in liver versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | decreased with PCB 153 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 126 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0; 250 mg/kg bw (PCB 77 or PCB 153); 25 mg/kg bw (PCB 126); 100, 250 or 500 mg/kg bw (Aroclor 1254) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | increased after 4 or 12 weeks | aminopyrine N-demethylase and aldrin epoxidase activities versus controls | Female | Adult | 4/treatment group | 0, 7 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | daily for 4, 8 or 12 weeks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | decreased after 4 weeks | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | 0, 7 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | daily for 4, 8 or 12 weeks | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ 5.4, 10.7, 11.7 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 175, 349, 698 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 4.0 ug/kg egg (0.8-7.2) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | 177 ug/kg egg (77-264) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | decreased @ 349 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | decreased @ 5.4, 11.7 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased @ 5 ug/kg | weight of heart, liver and spleen versus controls | Not Reported | Embryo | 15-60/group | 0,5,10,25,50,100,200,400,800 ug/kg egg | TOX-REPRO - development | incubation period | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Toxicity Endpoint Type | Type |
---|---|---|---|
CARBARYL, CARBOFURAN, DDE (4,4'-) | review | TOX-REPRO - reproductive success | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Toxicity Endpoint Type | Type |
---|---|---|---|---|---|---|
ALDRIN, BRODIFACOUM, CARBOFURAN, CHLORDANE, DIELDRIN, ENDRIN, FAMPHUR, FENTHION, PHORATE, STRYCHNINE | review | summaries of mortality due to organochlorine, anticholinesterase, anticoagulant, strychnine pesticides | Not Reported | Not Reported | TOX-MORT - mortality in the field | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | productivity in contaminated versus uncontaminated sites | Both Male and Female | Adult | Rocky Mountain Arsenal National Wildlife Refuge | 3-4 nests on contaminated sites; 5-9 nests on uncontaminated sites | 0.18 ppm (uncontaminated), 1.15 ppm (contaminated) in soil within adult home ranges | TOX-REPRO - reproductive success | NR | habitat contamination | Toxicity Factor Datasets |
DIELDRIN | negative correlation | relationship between residue in plasma and survival | Not Reported | Juvenile | Rocky Mountain Arsenal National Wildlife Refuge | 6 birds (contaminated sites), 10 birds (uncontaminated sites) | 0.01 ppm (uncontaminated), 0.22 ppm (contaminated) in plasma | TOX-MORT - mortality in the field | NR | habitat contamination | Toxicity Factor Datasets |
DIELDRIN | no effect | daily and interval survival estimates on uncontaminated versus contaminated sites | Not Reported | Juvenile | Rocky Mountain Arsenal National Wildlife Refuge | 14 birds on contaminated sites; 41 birds on uncontaminated sites | 0.18 ppm (uncontaminated), 1.15 ppm (contaminated) in soil within adult home ranges | TOX-MORT - mortality in the field | NR | habitat contamination | Toxicity Factor Datasets |