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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 30% decrease at 625 mg/kg bw 25% decrease at 125 mg/kg bw | plasma creatine phosphokinase | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (47-57%) | brain delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (71-79%) | kidney delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (20-25%) | liver delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 40% at 625 mg/kg bw | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-MORT - dose-response data | 10 d | gavage | Toxicity Factor Datasets | |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | body weight at end of dosing relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | growth rate relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at all doses 1.4, 3.5, 5.5 ppm at 25, 125, 625 mg/kg bw, respectively | liver lead concentration | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at 125, 625 mg/kg bw 7.2, 15.5 ppm at 125, 625 mg/kg bw, respectively | kidney lead concentrations | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decrease at 10, 50 ppm | mean blood delta aminolevulinic acid dehydratase | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-EXP IND - biomarkers | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean packed cell volume and red blood cell hemoglobin | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | increase at 50 ppm 1.3 ppm (1.00 SD) males; 2.4 ppm (1.40 SD) females | mean lead concentration in liver | Both Male and Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean organ and carcass weights | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 1.13 ppm blood at 212 ppm; 1.69 ppm blood at 448 ppm | mean lead concentration in blood | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 7.84 ppm femur at 120 ppm; 16.60 ppm femur at 212 ppm; 18.44 ppm femur at 448 ppm | mean lead concentration in femur | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | no effect | packed cell volume, hemoglogin concentration, erythrocyte counts | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIMETHYLMERCURY | no effect | eggshell thickness | Female | Adult | Not Reported | 0, 10 ppm | TOX-REPRO - physiology | 3 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease | eggshell thickness | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | decrease | Calcium ATPase activity of shell gland | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | decrease | carbonic anhydrase activity of shell gland | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | calcium concentration in blood | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at all doses (15.1-29.2%) | eggshell thickness | Female | Adult | 2-5 pairs/dose | 0, 0.3, 3, 6, 10 ppm (wet wt) | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 5.53 mg/kg egg (wet wt) | mean DDE concentration in eggs (pooled analyses) | Both Male and Female | Embryo | N. Niagra Peninsula, Ontario | 10 eggs | 0.009 mg/kg plant; 0.343 mg/kg soil; 0.605 mg/kg worm; 0.016 mg/kg vole | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | eggshell thickness | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-REPRO - physiology | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | lead concentration in eggshell | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | 62.0 ppm tibia, 13.5 ppm humeri at 50 ppm | lead concentrations in bones | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | increased at 2, 3 mg/kg bw | abnormal posture, ataxia, paresis | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - behavioral effects | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | increase at 3 mg/kg bw | mortality rate 2 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 2, 3 mg/kg bw | cloacal temperature | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - whole animal | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 2, 3 mg/kg bw | plasma cholinesterase activity 2 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-EXP IND - biomarkers | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 1, 2, 3 mg/kg bw | brain acetylcholinesterase activity 10 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | increased at 2, 3 mg/kg bw | plasma glucose concentrations | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ACEPHATE, DDE (4,4'-) | no effect | prey capturing behavior | Not Reported | Adult | 5-6/group | 50 mg acephate/kg bw +/- 6 ppm DDE (wet wt) | TOX-Non-Repro-Sublethal - behavioral effects | single (acephate) chronic (DDE) | diet | Toxicity Factor Datasets |
ACEPHATE, DDE (4,4'-) | decrease for both treatments | median serum cholinesterase activity 24 hr post-dose | Not Reported | Adult | 5-6/group | 50 mg acephate/kg bw +/- 6 ppm DDE (wet wt) | TOX-EXP IND - biomarkers | single (acephate) chronic (DDE) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 1.05 (0.05 SE) ppm (wet wt) | lead concentration in liver | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 0.70 (0.20 SE) ppm (wet wt) | lead concentration in tibia | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 232 (9 SE) ppm (wet wt) | DDE concentration in carcass | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 10.4 (0.6 SE) ppm (wet wt) | DDE concentration in brain | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | decreased | bw (versus pre-study bw) | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-Non-Repro-Sublethal - whole animal | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 0.367 (0.129 SE) ppm at 49 mg/d | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 49 mg/d (lead shot) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |