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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | increased at 2, 3 mg/kg bw | abnormal posture, ataxia, paresis | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - behavioral effects | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | increase at 3 mg/kg bw | mortality rate 2 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 2, 3 mg/kg bw | cloacal temperature | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - whole animal | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 2, 3 mg/kg bw | plasma cholinesterase activity 2 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-EXP IND - biomarkers | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 1, 2, 3 mg/kg bw | brain acetylcholinesterase activity 10 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | increased at 2, 3 mg/kg bw | plasma glucose concentrations | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ACEPHATE, DDE (4,4'-) | no effect | prey capturing behavior | Not Reported | Adult | 5-6/group | 50 mg acephate/kg bw +/- 6 ppm DDE (wet wt) | TOX-Non-Repro-Sublethal - behavioral effects | single (acephate) chronic (DDE) | diet | Toxicity Factor Datasets |
ACEPHATE, DDE (4,4'-) | decrease for both treatments | median serum cholinesterase activity 24 hr post-dose | Not Reported | Adult | 5-6/group | 50 mg acephate/kg bw +/- 6 ppm DDE (wet wt) | TOX-EXP IND - biomarkers | single (acephate) chronic (DDE) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 1.05 (0.05 SE) ppm (wet wt) | lead concentration in liver | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 0.70 (0.20 SE) ppm (wet wt) | lead concentration in tibia | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 232 (9 SE) ppm (wet wt) | DDE concentration in carcass | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 10.4 (0.6 SE) ppm (wet wt) | DDE concentration in brain | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | decreased | bw (versus pre-study bw) | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-Non-Repro-Sublethal - whole animal | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 0.367 (0.129 SE) ppm at 49 mg/d | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 49 mg/d (lead shot) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD (elemental) | 28.70 (2.6 SE) ppm at 49 mg/d | mean lead concentration (wet wt) in bone | Female | Adult | 3/group | 49 mg/d (lead shot) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 0.357 (0.012 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 7.63 (1.03 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in bone | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CARBOFURAN | 3 | number of dead kestrels found on treated fields | Not Reported | Not Reported | 44 fields | 0.23 kg/305 m application | TOX-MORT - mortality in the field | NR | field application | Toxicity Factor Datasets |
CARBOFURAN | 1.7-7.4 ppm (wet wt) | carcass residues of kestrels found dead | Not Reported | Not Reported | 3 birds | 0.23 kg/305 m application | TOX-EXP IND - accumulation | NR | multiple | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | no effect | variance in kestrel response time to prey stimulus | Not Reported | Adult | 6 | 6 ppm (wet wt) | TOX-Non-Repro-Sublethal - behavioral effects | 40 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 1.37 (0.10 SE) mg/kg | mean DDE concentration in blood (wet wt) | Not Reported | Adult | 6 | 6 ppm (wet wt) | TOX-EXP IND - accumulation | 58 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at 10 ppm | mean eggshell thickness | Female | Adult | 8-10 | 0, 10 ppm (dry wt) | TOX-REPRO - physiology | 1 yr | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 0.71 (0.05 SE) ppm at 0 ppm, 32.4 (2.78 SE) ppm at 10 ppm | mean residues in eggs | Female | Embryo | 9-10 | 0, 10 ppm (dry wt) | TOX-EXP IND - accumulation | 1 yr | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at 3 ppm | mean eggshell thickness | Female | Adult | 18 | 0, 3 ppm | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | 4.0 mg/kg bw (3.1-5.1 95% CI) | LD50 | Both Male and Female | Adult | 5/group | 2.2-11 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
FENTHION | 1.4 mg/kg bw | LD50 | Both Male and Female | Adult | 5/group | 0.5-2.4 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
CARBOFURAN | 0.6 mg/kg bw (0.5-1.0 95% CI) | LD50 | Both Male and Female | Adult | 5/group | 0.3-1.8 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
MONOCROTOPHOS | 1.5 mg/kg bw | LD50 | Both Male and Female | Adult | 5/group | 0.7-3.3 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
EPN | 68% (10.0 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 12 | 2.2-11 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
FENTHION | 88% (2.7 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 8 | 0.5-2.4 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
CARBOFURAN | 83% (4.3 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 12 | 0.3-1.8 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 984.1-1438.6 ppm (dry wt) | brain residues in birds that died | Male | Adult | 2 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 14-16 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 232.9 ppm (dry wt) | mean brain residues in birds that survived | Male | Adult | 11 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 12-15 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 507-877.1 ppm (dry wt) | liver residues in birds that died | Male | Adult | 2 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 14-16 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 88.1 ppm (dry wt) | mean liver residues in birds that survived | Male | Adult | 11 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 12-15 mos | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 10% decrease | eggshell thickness change relative to control | Female | Adult | Cayuga Lake Basin | 34 eggs | 33.2-41.9 ppm (dry wt) in eggs | TOX-REPRO - physiology | NR | parent diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FENTHION | 100% | Male | Adult | 14 | 1.1-6.1 ug/g sparrow | TOX-MORT - dose-response data | 1-3 d | diet | Toxicity Factor Datasets | |
FENTHION | 77.9-92% | range of brain acetylcholinesterase inhibition (relative to control) in birds that died | Male | Adult | 14 | 1.1-6.1 ug/g sparrow | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1-3 d | diet | Toxicity Factor Datasets |
FENTHION | 96% | range of plasma cholinesterase inhibition (relative to control) in birds that died | Male | Adult | 14 | 1.1-6.1 ug/g sparrow | TOX-EXP IND - biomarkers | 1-3 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 0.24 ug/g at study area, 0.087 ug/g at reference area | mean lead concentration in blood (wet wt) | Both Male and Female | Nestling | Coeur D'Alene River | 30 (study area) 22 (reference) | 3.0-1640 ug/g (wet wt) in prey species | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |