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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | decreased compared with reference | hatching success (# hatched/# eggs) | Both Male and Female | Hatchling | Spider Is., Lake Michigan | 466 and 953 nests (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | decreased compared with reference | clutch size | Female | Adult | Spider Is., Lake Michigan | 466 and 953 nests (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | increased compared with reference | proportion of nestlings with bill defects | Both Male and Female | Hatchling | Spider Is., Lake Michigan | 1,511 and 2,700 chicks (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Range | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 31.3 | mean biomagnification factor for eggs from forage fish | 11.7-56.8 | Female | Adult | 12 eggs/site x 5 sites | 5.8-24.4 pgTCDD equivalents/g fish, wet wt, (5 sites) | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 162.4 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | Green Bay, Lake Michigan | 20 chicks | 24.4 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 100.4 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained from egg to largest chick stage | Not Reported | Nestling | Beaver Islands, Lake Michigan | 20 chicks | 5.8 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 37.6 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | Thunder Bay, Lake Huron | 20 chicks | 18.1 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 28.3 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | North Channel, Lake Huron | 20 chicks | 7.6 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 47.5 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | St. Martin's Shoal, Lake Huron | 20 chicks | 11.1 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED DIBENZO-P-DIOXINS | increased | P-450-dependent arachidonic acid metabolism by liver microsomes | Not Reported | Embryo | 3 | 100 ug/kg egg | TOX-EXP IND - biomarkers | 5-6 d | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 95% | percent of eggs lost or broken before hatching in contaminated colonies | Not Reported | Embryo | Lake Huron | 235 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 23.9% thinner | eggshell thickness compared with pre-1947 eggshells in contaminated colonies | Not Reported | Embryo | Lake Huron | 18 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 2.4% | mean hatching success in contaminated colonies | Not Reported | Embryo | Lake Huron | 331 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 0.06-0.11 (1972); 0.3 (1973) | fledging success (young/nest) in contaminated colonies | Not Reported | Embryo | Lake Huron | 42 (1973)-66 (1972) nests | mean ppm, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of embryonic deformities, depressed growth | Embryo, Juvenile | Not Reported | NR | TOX-REPRO - development | NR | NR | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS, POLYCHLORINATED DIBENZO-P-DIOXINS | review | enzyme induction | Not Reported | NR | TOX-EXP IND - biomarkers | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ 5.4, 10.7, 11.7 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 175, 349, 698 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 4.0 ug/kg egg (0.8-7.2) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | 177 ug/kg egg (77-264) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | decreased @ 349 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | decreased @ 5.4, 11.7 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased @ 5 ug/kg | weight of heart, liver and spleen versus controls | Not Reported | Embryo | 15-60/group | 0,5,10,25,50,100,200,400,800 ug/kg egg | TOX-REPRO - development | incubation period | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | significantly decreased compared to pre-1943 samples | eggshell thickness (of intact or broken eggshells) | Female | Adult | Anacapa Island and Isla Coronado Norte | 86 eggs | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | increased compared to positive control (1969 data) | mean number of fledglings produced per nest in 1974 | Both Male and Female | Fledgling | Anacapa Island and Isla Coronado Norte | 1286 nests | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | non-detectable DDT plus TDE, 96.6 ppm DDE, lipid wet basis | concentration in egg contents | Female | Adult | Anacapa Island and Isla Coronado Norte | 39 eggs | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN | 0.896 ppm DDE, 0.256 ppm DDD, 0.166 ppm DDT, 0.208 dieldrin, 2.241 ppm PCB 1254 | mean residues in eggs | Female | Adult | east coast | 29 eggs | 0.017 ppm DDE, 0.016 ppm DDD, 0.020 ppm DDT, 0.005 ppm dieldrin, 0.196 ppm PCB 1254, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 8 ug/g | critical threshold of DDE concentration in egg (wet wt basis) associated with 20% eggshell thinning | Both Male and Female | Embryo | 813 eggs | ND-100 ug/g in eggs | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 3 ug/g | lowest level of DDE that would result in severely lowered reproductive success | Both Male and Female | Embryo | 156 eggs | ND-9 ug/g in eggs | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 3 ug/g | level in eggs associated with impaired reproductive success (successful nests fledged at least one chick) | Both Male and Female | Juvenile | 156 eggs | 0.36-8.60 ppm, wet wt in eggs | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
FUEL OILS | decrease | hatching success (proportion of eggs hatched per clutch) of oiled versus control eggs | Not Reported | Embryo | Cape Fear River | 61-205 eggs | oil spill | TOX-REPRO - reproductive success | NR | egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ARSENIC COMPOUNDS, MERCURY COMPOUNDS, POLYCHLORINATED DIBENZO-P-DIOXINS, SELENIUM COMPOUNDS | no effect | half-peak coefficient of variation (HPCV) in DNA content vs. reference samples | Not Reported | Chick | Ferry Slip Island and South Pelican Island (33deg59'N,77deg57'W) | 15 | geometric means: 0.03 ppm As, 0.38 ppm Se, 0.34 ppm Hg, 4.5 pg/g TCDD-EQs, wet wt in eggs | TOX-Non-Repro-Sublethal - genetic effects | NR | habitat contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of reproductive effects | Both Adults and Juveniles, Embryo | Not Reported | NR | TOX-REPRO - reproductive success | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MERCURY (elemental) | 0.81 ± 0.50 µg/g dw | Feather concentration | Both Male and Female | Nestling | Georgia & South Carolina | 10 | NR | TOX-EXP IND - accumulation | Environmental Contamination | Toxicity Factor Datasets |
METHYLMERCURY | Review, see citation Figure 2 | Egg concentration | Embryo | Not reported | NR | TOX-EXP IND - accumulation | Toxicity Factor Datasets | |||
METHYLMERCURY | Review, see ciation Figure 3 | Feather concentration | Not Reported | Not reported | NR | TOX-EXP IND - accumulation | Toxicity Factor Datasets |