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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 1, 5, 10 ul | 18-d % survival, mean embryonic weight, crown-rump length (5ul) and bill length | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
CRUDE OILS | increase @ 1, 5 ul | % abnormal survivors, compared to controls | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | onset of laying, egg production, egg fertility, compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - physiology | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease | egg hatchability (# eggs hatching/# fertile eggs), compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - reproductive success | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | onset of laying, egg production, egg fertility and egg hatchability, compared to controls | Female | Adult | 20 hens/dose | control, 5 ppm | TOX-REPRO - physiology | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCYCLIC AROMATIC HYDROCARBONS (PAHs) | increase @ 0.2, 2.0 mg/kg egg | embryonic mortality, compared to controls | Not Reported | Embryo | 22/dose | control, 0.2, 2.0 mg/kg egg, mixture of 18 PAHs; injected into egg yolks | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
BENZO[k]FLUORANTHENE | increase @ 0.2, 2.0 mg/kg egg | embryo mortality, compared to controls | Not Reported | Embryo | 20/dose | control, 0.2, 2.0 mg benzo[k]fluoranthene/kg egg; injected into egg yolks | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | decrease @ 0.5% | body weight, average daily weight gain and tibiotarsus length, compared to controls | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-Non-Repro-Sublethal - whole animal | 15 d | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | 3.59 ppm dry wt @ control, 5.16 ppm @ 0.1%, 15.52 ppm @ 0.05% | liver aluminum concentrations (ppm, dry wt) in ducklings | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-EXP IND - accumulation | 15 d | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | no effect | plasma growth hormone and insulin-like growth factor-I concentrations | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 15 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SEWAGE SLUDGE | no effect | immune defenses; resistance to Pasturella multocida estimated by % mortality 14 d after challenge, compared to controls | Male | Adult | 10/dose | control, 5%, 20% Milorganite or Metrogro | TOX-Non-Repro-Sublethal - organ/system effects | 28 d (Milorganite); 57 d (Metrogro) | diet | Toxicity Factor Datasets |
SEWAGE SLUDGE | increase @ 20% Milorganite or Metrogro | liver cadmium concentrations; compared to controls | Male | Adult | 10/dose | control, 5%, 20% Milorganite or Metrogro | TOX-EXP IND - accumulation | 28 d (Milorganite); 57 d (Metrogro) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TRIMETHYLTIN CHLORIDE | increase @ 5, 50 ppm | % mortality (100% mortality within 5 d for 50 ppm dose), compared to controls | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-MORT - dose-response data | 73 - 75 d | diet | Toxicity Factor Datasets |
TRIMETHYLTIN CHLORIDE | increase @ 50 ppm | incidence of mild to marked degeneration of neurons of the pons, medulla oblongata, gray matter of the spinal cord and pyrimidal cells of the cerebral cortex; mild to moderate lympoid depletion of spleen and thymus; atrophy of myofibers in skeletal and ca | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 73-75 d | diet | Toxicity Factor Datasets |
TRIMETHYLTIN CHLORIDE | 17% decrease @ 5 ppm | body weight | Not Reported | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - whole animal | 73 - 75 d | diet | Toxicity Factor Datasets | |
TRIMETHYLTIN CHLORIDE | increase @ 5 ppm | cephalic tumor incidence | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 73 - 75 d | diet | Toxicity Factor Datasets |
TRIETHYLTIN CHLORIDE | no effect | % mortality, compared to controls | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as triethyltin chloride | TOX-MORT - dose-response data | 73 - 75 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | 6.96 mg/kg bw (2.66-8.96 95% CI) | 24 hour median lethal dose | Female | Adult | 6 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 6.46 mg/kg bw (5.19-7.69 95% CI) | 24 hour median lethal dose | Male | Adult | 4-5 birds/dose | 0, 2, 4, 5.2, 6.1, 7.1, 8.0, 9.1 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 3.90 mg/kg bw (3.24-4.69 95% CI) | 24 hour median lethal dose | Female | Adult | 4-5 birds/dose | 0, 1.0, 2.0, 3.4, 4.0, 6.5 mg/kg bw (pelletized) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ARSENIC COMPOUNDS, MERCURY COMPOUNDS, POLYCHLORINATED DIBENZO-P-DIOXINS, SELENIUM COMPOUNDS | no effect | half-peak coefficient of variation (HPCV) in DNA content vs. reference samples | Not Reported | Chick | Ferry Slip Island and South Pelican Island (33deg59'N,77deg57'W) | 15 | geometric means: 0.03 ppm As, 0.38 ppm Se, 0.34 ppm Hg, 4.5 pg/g TCDD-EQs, wet wt in eggs | TOX-Non-Repro-Sublethal - genetic effects | NR | habitat contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED DIBENZO-P-DIOXINS | increased | P-450-dependent arachidonic acid metabolism by liver microsomes | Not Reported | Embryo | 3 | 100 ug/kg egg | TOX-EXP IND - biomarkers | 5-6 d | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 95% | percent of eggs lost or broken before hatching in contaminated colonies | Not Reported | Embryo | Lake Huron | 235 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 23.9% thinner | eggshell thickness compared with pre-1947 eggshells in contaminated colonies | Not Reported | Embryo | Lake Huron | 18 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 2.4% | mean hatching success in contaminated colonies | Not Reported | Embryo | Lake Huron | 331 eggs | mean ppm in 18 eggs, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, HEXACHLOROBENZENE, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | 0.06-0.11 (1972); 0.3 (1973) | fledging success (young/nest) in contaminated colonies | Not Reported | Embryo | Lake Huron | 42 (1973)-66 (1972) nests | mean ppm, wet wt: 14.5 (DDE), 0.22 (DDT), 0.17 (DDD), 23.8 (PCBs), 0.33 (dieldrin), 0.04 (heptachlor epoxide), 0.01 (hexachlorobenzene), 0.46 (Hg) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of embryonic deformities, depressed growth | Embryo, Juvenile | Not Reported | NR | TOX-REPRO - development | NR | NR | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS, POLYCHLORINATED DIBENZO-P-DIOXINS | review | enzyme induction | Not Reported | NR | TOX-EXP IND - biomarkers | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ 5.4, 10.7, 11.7 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ 175, 349, 698 ug/kg egg | mortality in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - dose-response data | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 4.0 ug/kg egg (0.8-7.2) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | 177 ug/kg egg (77-264) | LD50 (95% confidence limits) | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-MORT - toxicity benchmarks | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | increased @ all doses | hepatic EROD activity in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) | decreased @ 349 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 70, 175, 349, 698 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | decreased @ 5.4, 11.7 ug/kg egg | spleen weights in treated embryos versus controls | Not Reported | Embryo | Lake Winnipegosis, Manitoba | 83-86 eggs/treatment | 0, 1.3, 5.4, 10.7, 11.7 ug/kg egg | TOX-REPRO - development | 26-28 d | egg yolk injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased @ 5 ug/kg | weight of heart, liver and spleen versus controls | Not Reported | Embryo | 15-60/group | 0,5,10,25,50,100,200,400,800 ug/kg egg | TOX-REPRO - development | incubation period | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of reproductive effects | Both Adults and Juveniles, Embryo | Not Reported | NR | TOX-REPRO - reproductive success | NR | NR | Toxicity Factor Datasets |