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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, DDE (4,4'-) | see citation | figure of # eggs/female/wk over time | Female | Adult | 10/dose | 0, 40 ppm DDE + 40 ppm PCB | TOX-REPRO - reproductive success | 50 - 52 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 373 (95% CL; 152-574) ppm lipid basis @ 40 ppm diet | DDE residue concentrations in eggs | Female | Adult | 12 | 0, 40 ppm DDE | TOX-EXP IND - accumulation | 8-94 d | diet | Toxicity Factor Datasets |
AROCLOR 1254, DDE (4,4'-) | 344 (95% CL; 156-686) ppm DDE lipid basis and 346 (95%CL; 133-686) ppm PCB lipid basis @ 40 ppm DDE + 40 ppm PCB diet | mean DDE and PCB residue levels in eggs | Female | Adult | 13 | 0, 40 ppm DDE + 40 ppm PCB | TOX-EXP IND - accumulation | 7-128 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
VANADYL SULFATE | no effect | body weight and food consumption compared among groups | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | increased @ 100 ppm (maximum = 106 +/- 19 ppb, wet wt) | vanadium concentration in blood (sampled at 3 wk intervals) | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | brain, 9(1); fat, 20(11); kidney, 273(49); liver, 657(113), male femur 274(47); female femur 3327(2208) ppm, wet wt | mean (SE) vanadium concentrations @ 100 ppm dose in brain, fat, kidney, liver, and femur | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | <0.02 ppb, wet wt @ 1, 10 ppm; 63 ppb, wet wt @ 100 ppm | vanadium concentration in eggs | Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | increased @ 100 ppm | plasma cholesterol levels in drakes and laying hens | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 12 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase @ 2-15 ul/egg | percent mortality versus controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - reproductive success | single | application to egg surface | Toxicity Factor Datasets |
CRUDE OILS | increase @ 2-15 ul/egg | incidence of survivors with abnormalities versus controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - development | single | application to egg surface | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 15 ul/egg | red blood cell and liver ALAD activity and hemoglobin concentration, compared to controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - physiology | single | application to egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease | egg weight, length and breadth, compared to control | Female | Adult | 25/dose | control, 2% south Louisiana crude oil (w/w) | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | egg weight, length or breadth, compared to control | Female | Adult | 21-25/dose | control, 10 ppm DDE | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 5% | growth rate, estimated as change in body weight, compared to control | Both Male and Female | Juvenile | 50/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - whole animal | 8 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 0.25 - 5% | distance retreated from a frightening stimulus; impaired avoidance behavior | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - behavioral effects | 6 d | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 2.5 - 5% | incidence of liver hypertrophy and splenic atropy | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 8 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 2.5 - 5% | hematocrit, compared to control | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - organ/system effects | 8 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 0.25 - 5.0% | plasma alanine aminotransferase activity, from liver | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 8 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 0.025 - 5% | pathological release of ornithine carbamyltransferase from kidney | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 8 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 5% | incidence of degeneration of kidney tubules | Both Male and Female | Juvenile | 10/dose | 0, 0.025, 0.25, 2.5, 5% south Louisiana crude oil | TOX-Non-Repro-Sublethal - organ/system effects | 8 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | body weight and delta-aminolevulinic acid dehydratase activity versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased | erythrocyte protoporphyrin concentrations versus controls | Male | Adult | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight and hematocrit versus controls | Male | Juvenile | 20/treatment group | 0, 1 #four lead shot | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | 60% @ 2 shot, 30% @ 4 shot | cumulative mortality | Male | Adult | 10/treatment group | 0, 2, or 4 #four lead shot | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 2 #four shot | mortality versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-MORT - dose-response data | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 931,000 shot/acre or 2 #four pellets | spleen weight and total white blood cell counts versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 12 (control); 16 (lab); 63 (field) | 0, 931,000 shot/acre (field exposure) or 2 # four shot (lab exposure) | TOX-Non-Repro-Sublethal - organ/system effects | single (lab exposure) 80 d (field exposure) | oral intubation (lab exposure) ingestion (field exposure) | Toxicity Factor Datasets |
LEAD (elemental) | ppm wet wt: 3.47 (1.38), blood; 32.16 (11.60), liver; 114.78 (28.96), femur @ 2 #four shot | mean (2SE) lead concentration in liver, femur and blood | Male | Adult | 11 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | ppm wet wt: 4.15 (3.56), blood; 13.85 (7.96), liver; 577.07 (156.4), femur@ 2 #four shot | mean (2SE) lead concentrations in liver, femur and blood | Female | Adult | 5 birds | 2 # four shot | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets | |
LEAD (elemental) | decreased @ 2 #four shot | spleen plaque forming cell counts, % packed cell volume versus controls | Both Male and Female | Adult | Sacramento National Wildlife Refuge | 16 (2 #four shot) 63 (field exposure) | 0, 931,000 shot/acre or 2 # four shot | TOX-Non-Repro-Sublethal - organ/system effects | single (shot) 80 d (field exposure) | oral intubation (2 #four shot) ingestion (field exposure) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | serum glutamic pyruvic transaminase activity vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased with all treatments | incidence of hemosiderosis in liver vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | increased @ 8 #four iron shot | incidence of inclusion bodies in kidney vs controls | Female | Adult | 8/group | 0, 4 or 8 #four iron shot, 8 #six lead shot | TOX-Non-Repro-Sublethal - organ/system effects | single | oral intubation | Toxicity Factor Datasets |
IRON (elemental), LEAD (elemental) | no effect | serum enzyme levels versus controls (at 30 or 60 d post dose) | Male | Adult | 2/group | 0, 8, 16, 32, 64 #four iron shot | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased @ > 60 ug/dl blood | delta-aminolevulinic acid dehydratase activity | Both Male and Female | Not Reported | World Wildlife Fund Refuge, Tuscany | 21 birds | 10-120 ug/dl blood (mean 46 +/- 25 sd) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination (primary uptake via ingestion) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 7, 14, 21 d post-dose | concentration of lead in blood versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-EXP IND - accumulation | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | body weight versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - whole animal | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased @ 1 #four shot | mortality rate by 15 d post-dose versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-MORT - dose-response data | single | oral intubation | Toxicity Factor Datasets |
LEAD (elemental) | decreased @ 1 #four shot, 7, 14, 21 d. post-dose | agglutination titers to sheep red blood cells versus controls | Male | Adult | 4/group | 0, 1 #four shot plus SRBC immune challenge at 0, 7, 14, 21 d post-dose | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ENDRIN | breast muscle=non-detect.; liver=non-detect.-0.05; fat=non-detect.-0.50 ppm, wet wt | tissue endrin residues | Not Reported | Not Reported | Wenatchee | 7-10 animals | 1.3-1.7 kg/ha | TOX-EXP IND - accumulation | NR | pesticide application (late fall) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | no effect (3 or 8 d) | open field behavior scores versus controls | Not Reported | Juvenile | 26-28/group | 0,5,50,500 ppm lead as lead nitrate | TOX-Non-Repro-Sublethal - behavioral effects | 3 or 8 d | diet | Toxicity Factor Datasets |