SELENOMETHIONINE

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Mallard duck (Anas platyrhynchos)

Citation:

Selenium accumulation and loss in mallard eggs

Author(s)
Heinz, Gary H.
Pages
775-778
Year
Volume
12
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENOMETHIONINE 13-20 ppm, wet wt mean Se concentration in eggs Female Adult 5 birds Toxicity Factor Datasets Laboratory
Citation:

Embryotoxic and teratogenic effects of selenium in the diet of mallards

Author(s)
Hoffman, David J. and Gary H. Heinz
Pages
477-490
Year
Volume
24
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENITE, SODIUM, SELENOMETHIONINE increased @ 10,25 ppm (as selenite), 10 ppm (as selenomethionine) number of embryos showing malformations or embryotoxicity compared to controls Not Reported Embryo 5-11 pairs/group Toxicity Factor Datasets Laboratory
SELENOMETHIONINE increased @ 8, 16 ppm incidence of malformed embyros compared to controls Not Reported Embryo 5-11 pairs/group Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE increased @ 25 ppm plasma uric acid concentration in hatchlings versus controls Not Reported Juvenile 5-11 pairs/group Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE increased @ 5, 10, 25 ppm (as selenite), 10 ppm (as selenomethionine) plasma glutathione peroxidase activity in hatchlings compared to controls Not Reported Juvenile 5-11 pairs/group Toxicity Factor Datasets Laboratory
Citation:

Interactive effects of boron, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings

Author(s)
Hoffman, David J., Caroline J. Sanderson, Leonard J. LeCaptain, Eugene Cromartie and Grey W. Pendleton
Pages
288-294
Year
Volume
20
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
BORIC ACID, SELENOMETHIONINE increased @ 15 ppm Se (with and w/out B), 1000 ppm B incidence of plasma chemistry changes versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE decreased @ 1000 ppm B hematocrits and hemoglobin concentrations versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE decreased @ 15 ppm Se (with or w/out B), and 1000 ppm B hematocrits and hemoglobin concentrations versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE 10.8 (@ 15 ppm Se), 56.0 (@ 60 ppm) ppm Se, wet wt
11.0 (@ 1000 ppm B) ppm B, wet wt 		geometric mean Se and B concentrations in liver Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE 22.5 (@ 15 ppm Se w/out B), 41.9 (@ 15 ppm Se w/B) ppm Se, wet wt
13.0 (@ 1000 ppm B) ppm B, wet wt 		geometric mean Se and B concentrations in liver Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE decreased @ 60 ppm Se (47% mort.) survival versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
BORIC ACID, SELENOMETHIONINE decreased @ 60 ppm Se body, liver, and spleen weight; tarsus length versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets day old Laboratory
Citation:

Diagnostic criteria for selenium toxicosis in aquatic birds: Dietary exposure, tissue concentrations and macroscopic effects

Author(s)
Albers, Peter H., D. Earl Green and Caroline J. Sanderson
Pages
468-485
Year
Volume
32
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE increased in birds that died incidence of macroscopic abnormalities versus controls Male Adult 21/dose Toxicity Factor Datasets 1 yr Laboratory
SELENOMETHIONINE increased @ 40 ppm incidence of macroscopic abnormalities of muscles, claws and feathers versus controls Male Adult 21/dose Toxicity Factor Datasets 1 yr Laboratory
SELENOMETHIONINE decreased in birds that died mean weights of heart, spleen, pancreas, testis versus controls Male Adult 21/dose Toxicity Factor Datasets 1 yr Laboratory
SELENOMETHIONINE 33(7) ppm @ 10 ppm Se, 49(9) ppm @ 20 ppm Se, 87(11) ppm @ 40 ppm Se, 99(9) ppm in birds that died mean (SE) dry wt concentrations of selenium in liver Male Adult 10-25 Toxicity Factor Datasets 1 yr Laboratory
Citation:

Effects of boron and selenium on mallard reproduction and duckling growth and survival

Author(s)
Stanley, Thomas R., Jr., Gregory J. Smith, David J. Hoffman, Gary H. Heinz, and Roger Rosscoe
Pages
1124-1132
Year
Issue
7
Volume
15
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
BORIC ACID, SELENOMETHIONINE increased @ 3.5 ppm Se survival between 7 and 14 days post-hatch versus controls Both Male and Female Juvenile 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 7 ppm duckling production versus 3.5 ppm Se group Both Male and Female Both Adults and Juveniles 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE 4.6 (0.18) ppm B @ 450 ppm B; 8.5 (0.34) ppm B @ 900 ppm B; 3.7 (0.16) ppm Se @ 3.5 ppm Se; 6.2 (0.27) ppm Se @ 7 ppm mean (SE) wet wt concentrations of B and Se in liver Both Male and Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE 6.5 (0.25) ppm B @ 450 ppm B; 11 (0.4) ppm B @ 900 ppm B; 3.5 (0.10) ppm Se @ 3.5 ppm Se; 7.1 (0.28) ppm Se @ 7 ppm mean (SE) wet wt concentrations of B and Se in egg Both Male and Female Both Adults and Juveniles 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 900 ppm B body weight versus controls Both Male and Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE decreased @ 900 ppm B liver weight versus 450 ppm B group Male Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 900 ppm B hemoglobin concentrations versus controls Male Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE no effect onset of egg laying, eggshell thickness, frequency of embryo deformities versus controls Both Male and Female Both Adults and Juveniles 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 900 ppm B egg weight, hatching success, egg fertility versus controls Both Male and Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 7 ppm Se body weight versus controls Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE no effect due to added Se liver weight, hemoglobin concentrations, hematocrit versus controls Both Male and Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE no effect due to added Se onset of egg laying, eggshell thickness, egg weight, egg fertility, embryo deformities versus controls Both Male and Female Both Adults and Juveniles 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
BORIC ACID, SELENOMETHIONINE reduced @ 7 ppm Se hatching success versus controls Female Adult 14 pairs/treatment Toxicity Factor Datasets 1 yr Laboratory
Citation:

Effects of mercury and selenium on glutathione metabolism and oxidative stress in mallards

Author(s)
Hoffman, David J., and Gary H. Heinz
Pages
161-166
Year
Issue
2
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Hg + 10 ppm Se plasma glucose concentrations versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE decreased @ 10 ppm Se, 10 ppm Hg, 10 ppm Hg + 10 ppm Se plasma phosphorus concentrations versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE decreased @ 10 ppm Hg glutathione peroxidase activity (plasma and liver) and glucose-6-phosphate dehydrogenase (liver and brain) versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Se hepatic GSSG reductase activity versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Hg oxidized glutathione (GSSG) level versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE reduced @ 10 ppm Hg, 10 ppm Hg + 10 ppm Se protein-bound sulfhydryl in liver versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Hg, 10 ppm Se, 10 ppm Hg + 10 ppm Se thiobarbituric acid-reactive substances in brain versus controls Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE 3.4(0.22) ppm @ 10 ppm Se; 5.2(0.44) ppm @ 10 ppm Hg + 10 ppm Se mean (SE) wet wt Se concentrations in brain Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE 17.9(1.06) ppm @ 10 ppm Hg; 14.1(0.74) ppm @ 10 ppm Hg + 10 ppm Se mean (SE) wet wt Hg concentrations in brain Male Adult 12/treatment Toxicity Factor Datasets 18 mo Laboratory
Citation:

Toxicity of seleno-L-methionine, seleno-DL-methionine, high selenium wheat, and selenized yeast to mallard ducklings

Author(s)
Heinz, Gary H., David J. Hoffman and Leonard J. LeCaptain
Pages
93-99
Year
Volume
30
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENIUM COMPOUNDS, SELENOMETHIONINE decreased @ 30 ppm as Se-met or yeast, or 15 ppm as wheat food consumption compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE decreased @ 30 ppm as Se-met or yeast body weight compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE decreased @ 30 ppm as Se-L-met survival rate compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE 11-12 (@ 15 ppm as Se-met or wheat), 6.2 (@ 15 ppm as yeast), 19-20 (@ 30 ppm as Se-met or wheat), 9.9 (@ 30 ppm as yeast) ppm, wet wt mean concentrations of Se in livers Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE decreased @ 30 ppm (as Se-met or yeast) food consumption compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE decreased @ 30 ppm (as Se-met or yeast) body weights compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE no effect survival rate compared to controls Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE 25-27 (@ 30 ppm as Se-L-met or Se-DL-met), 13 (@ 30 ppm as yeast) ppm, wet wt mean Se concentrations in liver Not Reported Juvenile 25 birds/group Toxicity Factor Datasets 1 day Laboratory
Citation:

Subchronic effects of sodium selenite and selenomethionine on several immune functions in mallards.

Author(s)
Fairbrother, A. and J. Fowles
Pages
836-844
Year
Volume
19
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENOMETHIONINE decreased incidence of delayed hypersensitivity reactions to antigen versus controls Male Adult Controls = 24
Treated = 8 		Laboratory Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE decreased blood monocyte counts after 78 days exposure versus controls Male Adult Controls = 24
Treated = 8 		Laboratory Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE increased @ 3.5 mg/L (selenite) or 2.2 mg/L (selenomethionine) serum ALT enzyme activity versus controls n high selenite and selenomethionine groups. Male Adult Controls = 24
Treated = 8 		laboratory Toxicity Factor Datasets Laboratory
SELENOMETHIONINE increased (12-fold) selenium concentrations in pectoral muscle Male Adult Controls = 24
Treated = 8 		Laboratory Toxicity Factor Datasets Laboratory
Citation:

Toxicity of organic and inorganic selenium to mallard ducklings

Author(s)
Heinz, G.H., D.J. Hoffman and L.G. Gold
Pages
561-568
Year
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENITE, SODIUM, SELENOMETHIONINE increased @ 40, 80 ppm selenite or selenomethionine duckling mortality versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE decreased food consumption versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE decreased (liver decreased with selenite only) bw and liver wt versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets Laboratory
SELENITE, SODIUM, SELENOMETHIONINE no effect tarsus length, 10th primary length, heart weight versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets Laboratory
SELENOMETHIONINE 60(14.2) ppm, wet wt @ 40 ppm; 51(5.2) ppm, wet wt @ 80 ppm mean liver concentrations (SE) in ducklings fed selenomethionine that died Not Reported Juvenile 40 birds/group Toxicity Factor Datasets Laboratory
Citation:

Subchronic hepatotoxicity of selenomethionine ingestion in mallard ducks

Author(s)
Hoffman, David J., Gary H. Heinz, Leonard J. LeCaptain, Christine M. Bunck and David E. Greene
Pages
449-464
Year
Volume
32
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE increased @ 32 ppm incidence of liver histopathological lesions, liver:body wt ratios versus controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE increased @ 32 ppm plasma alkaline phosphatase activity and total protein levels versus controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE decreased @ 32 ppm body weight, liver DNA:RNA ratio, hematocrit compared to controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE decreased @ 16, 32 ppm hemoglobin concentration compared to controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE increased @ 2 ppm or greater plasma glutathione peroxidase activity versus controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE increased @ 16, 32 ppm liver reduced gluthathione, oxidized glutathione, malondialdehyde concentrations versus controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
SELENOMETHIONINE increased @ 2 ppm or greater Se concentrations in liver versus controls Male Adult 10 birds/group Toxicity Factor Datasets 2 yr Laboratory
Citation:

Comparison of the effects of seleno-L-methionine, seleno-D,L-methionine, and selenized yeast on reproduction in mallards

Author(s)
Heinz, Gary H. and David J. Hoffman
Pages
169-175
Year
Volume
91
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENIUM COMPOUNDS, SELENOMETHIONINE reduced with selenized yeast body weight of 6 day old ducklings versus controls Both Male and Female Both Adults and Juveniles 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE increased with seleno-D,L-methionine, seleno-L-methionine, or selenized yeast incidence of embryo deformities versus controls Both Male and Female Both Adults and Juveniles 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE no effect incidence of illness versus controls Both Male and Female Adult 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE 9.2(0.52) ppm with seleno-D,L-methionine; 8.9(0.35) ppm with seleno-L-methionine; 6.6(0.37) ppm with selenized yeast mean(SE) wet wt concentrations of selenium in 8th egg laid Female Adult 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE no effect egg fertility, egg weight, eggshell thickness, and mean interval between laying of eggs versus controls Both Male and Female Adult 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE reduced with seleno-L-methionine or seleno-D,L-methionine hatchability versus controls Both Male and Female Both Adults and Juveniles 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE reduced with seleno-L-methionine duckling survival compared to controls Both Male and Female Adult 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
SELENIUM COMPOUNDS, SELENOMETHIONINE reduced with seleno-D,L-methionine, seleno-L-methionine, or selenized yeast number of 6-day-old ducklings produced per female versus controls Both Male and Female Both Adults and Juveniles 15 pairs/treatment group, 10 pairs/control group Toxicity Factor Datasets Laboratory
Citation:

Toxicity and oxidative stress of different forms of organic selenium and dietary protein in mallard ducklings

Author(s)
Hoffman, D.J., G.H. Heinz, L.J. LeCaptain, J.D. Eisemann and G.W. Pendleton
Pages
120-127
Year
Volume
31
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENIUM COMPOUNDS, SELENOMETHIONINE increase @ 15, 30 ppm plasma and liver GSH-peroxidase activity (for all Se forms), compared to controls Not Reported Juvenile 10/dose Toxicity Factor Datasets 1 d Laboratory
Citation:

Selenium accumulation and elimination in mallards

Author(s)
Heinz, G.H., G.W. Pendleton, A.J. Krynitsky and L.G. Gold
Pages
374-379
Year
Volume
19
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENOMETHIONINE liver: C = 7.4(1-e^-0.382t)
muscle: C = 8.0(1-e^-0.037t) 		selenium accumulation equations Both Male and Female Adult 3 Toxicity Factor Datasets Laboratory
SELENOMETHIONINE liver: C = 7.4e^-0.037t
muscle: C = 5.6e^-0.023t
liver at peak body burden: C = 22.6e^-0.246t + 2.5 e^-0.008t
muscle at peak body burden: C = 6.4e^-0.029t
Loss phase for blood at peak body burden: C = 12.0e^-0.071t 		selenium depuration equations Both Male and Female Adult 3 Toxicity Factor Datasets Laboratory
SELENOMETHIONINE liver: 18.7 d
muscle: 30.1 d 		half life of selenium in tissues Both Male and Female Adult 3 Toxicity Factor Datasets Laboratory
Citation:

Interactive effects of selenium, methionine, and dietary protein on survival, growth, and physiology in mallard ducklings.

Author(s)
Hoffman, D.J., C.J. Sanderson, L.J. LeCaptain, E. Cromartie and G.W. Pendleton
Pages
163-171
Year
Volume
23
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE no effect % survival versus controls Not Reported Juvenile 15/group Toxicity Factor Datasets 1-day old Laboratory
SELENOMETHIONINE 11.6 (@15 ppm diet), 48.6 (@ 60 ppm diet) ppm, wet wt geometric mean Se concentration in liver (adequate protein in diet) Not Reported Juvenile 15/group Toxicity Factor Datasets 1-day old Laboratory
SELENOMETHIONINE increased @ 15 ppm, 60 ppm (adequate protein, no methionine added) incidence of histopathological changes in livers versus controls Not Reported Juvenile 15/group Toxicity Factor Datasets 1-day old Laboratory
SELENOMETHIONINE decreased @ 60 ppm (regardless of methionine suppl. or protein levels) body, liver and spleen weights, and tarsus length versus controls Not Reported Juvenile 15/group Toxicity Factor Datasets 1-day old Laboratory
SELENOMETHIONINE increased @ 15 (GSH-peroxidase only), 60 ppm Se, adequate protein plasma GSH-peroxidase and alkaline phosphatase activities versus controls Not Reported Juvenile 15/group Toxicity Factor Datasets 1-day old Laboratory
Citation:

Methylmercury chloride and selenomethionine interactions on health and reproduction in mallards

Author(s)
Heinz, Gary H., and David J. Hoffman
Pages
139-145
Year
Issue
2
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
METHYLMERCURY CHLORIDE, SELENOMETHIONINE no effect body weight versus controls Both Male and Female Adult 12/group Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Hg incidence of leg weakness versus controls Male Adult 12/group Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE decreased @ 10 ppm Hg, 10 ppm Hg + 10 ppm Se hatchability versus controls Both Male and Female Both Adults and Juveniles 12/group Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE no effect egg laying interval, egg weight, egg shell thickness, fertility, duckling survival, hatchling body weights versus controls Both Male and Female Both Adults and Juveniles 12/group Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE reduced @ 10 ppm Se, 10 ppm Hg + 10 ppm Se weight of 7 day old ducklings versus controls Both Male and Female Both Adults and Juveniles 12/group Toxicity Factor Datasets 18 mo Laboratory
METHYLMERCURY CHLORIDE, SELENOMETHIONINE increased @ 10 ppm Se, 10 ppm Hg, 10 ppm Hg + 10 ppm Se incidence of deformities in embryos that died (1 wk or older) versus controls Both Male and Female Both Adults and Juveniles 12/group Toxicity Factor Datasets 18 mo Laboratory
Citation:

Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings

Author(s)
Hoffman, David J., Gary H. Heinz and Alexander J. Krynitsky
Pages
263-271
Year
Volume
27
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE increased @ 10,20,40 ppm incidence of altered hepatic glutathione metabolism versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets day old Laboratory
SELENOMETHIONINE increased @ 20, 40 ppm hepatic malondialdehyde concentrations versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets day old Laboratory
SELENOMETHIONINE decreased @ 20, 40 ppm hepatic protein concentrations versus controls Not Reported Juvenile 40 birds/group Toxicity Factor Datasets day old Laboratory
SELENOMETHIONINE increased to 4.8 (@ 10 ppm), 26.0 (@ 20 ppm), 68.0 (@ 40 ppm) ppm, wet wt Se concentrations in livers after 6 wks of treatment Not Reported Juvenile 40 birds/group Toxicity Factor Datasets day old Laboratory
Citation:

Interactive effects of arsenate, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings

Author(s)
Hoffman, David J., Caroline J. Sanderson, Leonard J. LeCaptain, Eugene Cromartie and Grey W. Pendleton
Pages
55-62
Year
Volume
22
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
ARSENATE, SODIUM, SELENOMETHIONINE increased (40%) @ 60 ppm Se incidence of mortality versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets 1 d Laboratory
ARSENATE, SODIUM, SELENOMETHIONINE increased @ 60 ppm Se incidence of ducklings with histopathological lesions versus controls Not Reported Juvenile 15 birds/group Toxicity Factor Datasets 1 d Laboratory
Citation:

Diagnostic criteria for selenium toxicosis in aquatic birds: Histologic lesions

Author(s)
Green, D. Earl and Peter H. Albers
Pages
385-404
Year
Volume
33
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE no effect histological changes to nervous system, bones, feathers, feather follicles, claws and scaled skin versus controls Male Adult 21/dose Toxicity Factor Datasets 14 mo Laboratory
SELENOMETHIONINE increased in birds that died, and in some 40 ppm survivors histological changes to skin (loss of fat), muscle, liver, pancreas, kidney, lymph nodes, spleen, seminiferous tubules Male Adult 21/dose Toxicity Factor Datasets 14 mo Laboratory
Citation:

Behavior of mallard ducklings from adults exposed to selenium

Author(s)
Heinz, G.H. and L.G. Gold
Pages
863-865
Year
Volume
6
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
SELENOMETHIONINE no effect distance run in 2 seconds from a fright stimulus vs controls Not Reported Chick 32, 14, 14, 14, 11 in the 0, 1, 2, 4, and 8 ppm groups Toxicity Factor Datasets 6 days Laboratory

American Kestrel (Falco sparverius)

Citation:

Selenium accumulation and effects on reproduction in captive American kestrels fed selenomethionine

Author(s)
Santolo, Gary M., Julie T. Yamamoto, Jacqueline M. Pisenti, Barry W. Wilson
Pages
502-511
Year
Issue
2
Volume
63
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENOMETHIONINE no effect chick mass and size at hatch, and chick survival to fledging versus controls Both Male and Female Adult, Juvenile 15 pairs/treatment group; 10 control pairs Toxicity Factor Datasets Laboratory
SELENOMETHIONINE blood Se concentration = 1.307 + 0.852(diet Se concentration) relation between Se concentrations in blood (dry wt) and diet (dry wt) Male Adult 40 birds Toxicity Factor Datasets Laboratory
SELENOMETHIONINE egg Se concentration = 1.307 + 0.852(diet Se concentration) relation between Se concentrations in egg (dry wt) and diet (dry wt) Female Adult 53 eggs Toxicity Factor Datasets Laboratory
SELENOMETHIONINE increased @ 6 or 12 ppm Se food consumption versus controls Both Male and Female Adult 15 pairs/treatment group; 10 control pairs Toxicity Factor Datasets Laboratory
Citation:

Selenium accumulation in captive American kestrels (Falco sparverius) fed selenomethionine and naturally incorporated selenium

Author(s)
Yamamoto, Julie T., Gary M. Santolo, and Barry W. Wilson
Pages
2494-2497
Year
Issue
12
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
SELENOMETHIONINE Y=1.132 + 0.801X (R^2 = 0.932) relationship between Se concentrations in diet and blood Both Male and Female Adult 9-10 pairs/group Toxicity Factor Datasets Laboratory
SELENOMETHIONINE no effect incidence of mortality or signs of toxicity Both Male and Female Adult 9-10 pairs/group Toxicity Factor Datasets Laboratory
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