Subchronic hepatotoxicity of selenomethionine ingestion in mallard ducks

Author(s)

Hoffman, David J., Gary H. Heinz, Leonard J. LeCaptain, Christine M. Bunck and David E. Greene

Year

Tue, 01/01/1991 - 12:00

Article Title

Subchronic hepatotoxicity of selenomethionine ingestion in mallard ducks

Volume

Pages

449-464

Start Page Number

449

Final Page

464

Review

Datapoints

Displaying 1 - 7 of 7 datapoints.

Species: Mallard duck (Anas platyrhynchos)
Chemical	Toxicity Endpoint Type	Endpoint Description	Endpoint Value	Sample Size	Life Cycle Stage	Study Duration	Type
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - organ/system effects	incidence of liver histopathological lesions, liver:body wt ratios versus controls	increased @ 32 ppm	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - cellular/biochemical effects	plasma alkaline phosphatase activity and total protein levels versus controls	increased @ 32 ppm	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - whole animal	body weight, liver DNA:RNA ratio, hematocrit compared to controls	decreased @ 32 ppm	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - cellular/biochemical effects	hemoglobin concentration compared to controls	decreased @ 16, 32 ppm	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - cellular/biochemical effects	plasma glutathione peroxidase activity versus controls	increased @ 2 ppm or greater	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - organ/system effects	liver reduced gluthathione, oxidized glutathione, malondialdehyde concentrations versus controls	increased @ 16, 32 ppm	10 birds/group	Adult	14 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-EXP IND - accumulation	Se concentrations in liver versus controls	increased @ 2 ppm or greater	10 birds/group	Adult	14 wks	Toxicity Factor Datasets