Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings

Author(s)

Hoffman, David J., Gary H. Heinz and Alexander J. Krynitsky

Year

Sun, 01/01/1989 - 12:00

Article Title

Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings

Volume

Pages

263-271

Start Page Number

263

Final Page

271

Review

Datapoints

Displaying 1 - 10 of 10 datapoints.

Species: Mallard duck (Anas platyrhynchos)
Chemical	Toxicity Endpoint Type	Endpoint Description	Endpoint Value	Sample Size	Life Cycle Stage	Study Duration	Type
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - cellular/biochemical effects	incidence of altered hepatic glutathione metabolism versus controls	increased @ 10,20,40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENITE, SODIUM	TOX-Non-Repro-Sublethal - cellular/biochemical effects	incidence of altered hepatic glutathione metabolism versus controls	increased @ 10,20,40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - cellular/biochemical effects	hepatic malondialdehyde concentrations versus controls	increased @ 20, 40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENITE, SODIUM	TOX-Non-Repro-Sublethal - cellular/biochemical effects	hepatic malondialdehyde concentrations versus controls	increased @ 40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-Non-Repro-Sublethal - whole animal	hepatic protein concentrations versus controls	decreased @ 20, 40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENITE, SODIUM	TOX-Non-Repro-Sublethal - cellular/biochemical effects	hepatic protein concentrations versus controls	increased @ 20, 40 ppm	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-EXP IND - accumulation	Se concentrations in livers after 6 wks of treatment	increased to 4.8 (@ 10 ppm), 26.0 (@ 20 ppm), 68.0 (@ 40 ppm) ppm, wet wt	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENITE, SODIUM	TOX-EXP IND - accumulation	Se concentrations in livers after 6 wks of treatment versus controls	increased to 0.4 (@ 0 ppm), 5.0 (@ 10 ppm), 3.2 (@ 20 ppm), 2.8 (@ 40 ppm) ppm, wet wt	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENOMETHIONINE	TOX-MORT - dose-response data	mortality compared to controls	increased @ 40 ppm (25%)	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets
SELENITE, SODIUM	TOX-MORT - dose-response data	mortality compared to controls	increased @ 40 ppm (12.5%)	40 birds/group	Juvenile	6 wks	Toxicity Factor Datasets