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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | no effect | number of hatchlings per nest, percent hatchability, hatchling survival and body weight to 5 days compared with controls | Not Reported | Hatchling | 12 pairs/group | 400 ppm diet, beginning at egg laying, early incubation, or late incubation periods | TOX-REPRO - reproductive success | 8 d | diet | Toxicity Factor Datasets |
METHYLPARATHION | decreased when treatment initiated during laying, early or late incub. | food consumption compared with controls | Female | Adult | 12 pairs/group | 400 ppm diet, beginning at egg laying, early incubation, or late incubation periods | TOX-Non-Repro-Sublethal - behavioral effects | 8 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARATHION | decreased @ 0.75, 7.5 (aqueous) or 0.8 (oil) lb/acre | embryo weight by day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 0, 0.75, 7.5 lb/acre simulated, aqueous; 0, 0.08, 0.8 lb/acre simulated, oil | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
MALATHION | increased @ 125 lb/acre | cumulative mortality by day 18 compared with controls | Not Reported | Embryo | 30/group | 12.5, 125 lb/acre simulated, aqueous; 0, 1.4, 14.0 lb/acre simulated, oil | TOX-MORT - dose-response data | single | application to eggshell surface | Toxicity Factor Datasets |
MALATHION | 118 (day 3), 101 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 12.5, 125 lb/acre simulated, aqueous | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
PARATHION | 41(day 3), 39 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 0.75, 7.5 lb/acre simulated, aqueous | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
DIAZINON | 74 (day 3), 79 (day 8) lb/acre LC50 | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 1.5, 15 lb/acre simulated, aqueous | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
PARATHION | decreased @ 7.5 lb/acre (aqueous); 0.08, 0.8 lb/acre (oil) | crown-rump length at day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 0.75, 7.5 lb/acre simulated, aqueous; 0, 1.4, 14.0 lb/acre simulated, oil | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
MALATHION | decreased @ 125 lb/acre | crown-rump length at day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 12.5, 125 lb/acre simulated, aqueous | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
DIAZINON | decreased @ 2.0 lb/acre | crown-rump length at day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 0, 0.2, 2.0 lb/acre simulated, oil | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
MALATHION | 49.5 lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 0, 1.4, 14.0 lb/acre simulated, oil | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
DIAZINON | 9.7 (day 3), 11.1 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 0, 0.2, 2.0 lb/acre simulated, oil | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
PARATHION | 2.2 (day 3), 1.5 (day 8) lb/acre | LC50, exposed on day 3 or 8 of incubation | Not Reported | Embryo | 30/group | 0, 0.08, 0.8 lb/acre simulated, oil | TOX-MORT - toxicity benchmarks | single | application to eggshell surface | Toxicity Factor Datasets |
DIAZINON | decreased @ 15 (aqueous), 2.0 (oil) lb/acre | embryo weight by day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 0, 1.5, 15.0 lb/acre simulated, aqueous; 0, 0.2, 2.0 lb/acre simulated, oil | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
MALATHION | decreased @ 125 (aqueous), 14.0 (oil) lb/acre | embryo weight by day 18 of incubation compared with controls | Not Reported | Embryo | 30/group | 0, 12.5, 125 lb/acre simulated, aqueous; 0, 1.4, 14.0 lb/acre simulated, oil | TOX-REPRO - development | single | application to eggshell surface | Toxicity Factor Datasets |
DIAZINON, MALATHION, PARATHION | decreased @ all doses | brain or plasma cholinesterase activity in embryos or hatchlings compared to controls | Not Reported | Embryo, Hatchling | 12/group | 125 (malathion), 15 (diazinon), 7.5 (parathion) lb/acre simulated, aqueous; 14 (malathion), 2 (diazinon), 0.8 (parathion) lb/acre simulated, oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to eggshell surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ACEPHATE | 51.7% (4.82 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 350 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
DICROTOPHOS | 42.8% (5.4 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 2.4 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
FENSULFOTHION | 48.9% (7.6 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 0.75 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
FONOFOS | 67.1% (4.9 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 14 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
MALATHION | 67% (11.6 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 650 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
PARATHION | 74.6% (12.4 SE) | brain cholinesterase inhibition compared with controls | Not Reported | Juvenile | 36/dose | 0, 1.75 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
PARATHION | 4/36 | mortality incidence by 20 hrs post-dose | Not Reported | Juvenile | 36/dose | 0, 1.75 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
MALATHION | 7/36 | mortality incidence by 20 hrs post-dose | Not Reported | Juvenile | 36/dose | 0, 650 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
ACEPHATE | 11/36 | mortality incidence by 20 hrs post-dose | Not Reported | Juvenile | 36/dose | 0, 350 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEPTOPHOS | decreased @ 260 ppm | body weight growth compared with controls | Both Male and Female | Juvenile | 3-5/group | 0, 260 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 3 wks | diet | Toxicity Factor Datasets |
LEPTOPHOS | 5/5 @ 260 ppm | incidence of ataxia | Both Male and Female | Juvenile | 3-5/group | 0, 260 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 3 wks | diet | Toxicity Factor Datasets |
LEPTOPHOS | 4/5 @ 260 ppm | incidence of CNS lesions | Both Male and Female | Juvenile | 3-5/group | 0, 260 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 3 wks | diet | Toxicity Factor Datasets |
Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
see citation tables | LD50s for 42 compounds in aqueous and oil vehicles | Not Reported | Embryo | 30 eggs/group | see citation for doses of 42 compounds | TOX-MORT - toxicity benchmarks | single | eggshell surface application | Toxicity Factor Datasets |
see citation tables | incidence of reduced growth and abnormal survivors for 42 compounds | Not Reported | Embryo | 30 eggs/group | see citation for doses of 42 compounds | TOX-REPRO - development | single | eggshell surface application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 90, 270 ppm | food consumption and body weight compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
EPN | increased @ all doses | incidence of hyperactivity, ataxia, and/or paralysis compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
EPN | increased @ 30, 90, 270 ppm | incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
EPN | decreased @ all doses | activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
EPN | decreased @ 90, 270 pmm | plasma alkaline phosphatase activity compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 270, 540 ppm | body weight compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | increased @ all doses | incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 270 ppm | brain weight compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ all doses | activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 60, 270 ppm | plasma alkaline phosphatase activity compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |