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Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | review | Not Reported | Not Reported | Not Reported | multiple | TOX-Non-Repro-Sublethal - whole animal | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FLUORIDE, SODIUM | 247.0 +/- 103.1 ppm @ 0 ppm; 6137.9 +/- 823.8 ppm @ 1120 ppm; 10,272.6 +/- 865.8 ppm @ 2240 ppm | mean fluoride content in the diaphyses of femurae | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-EXP IND - accumulation | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | no effect | growth of body weight and skeletal components (skull, bill, tarsus, antebrachium, and manus) | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | increased at 1120, 2240 ppm | % bone ash | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | decreased at 2240 ppm | bonebreaking strength | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 153 | aminopyrine N-demethylase and aldrin epoxidase activities in liver | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wk | oral | Toxicity Factor Datasets |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 105 | aminopyrine N-demethylase activity in liver | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wk | oral | Toxicity Factor Datasets |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 126 | 7-ethoxyresorufin O-deethylase and aldrin epoxidase activities in liver | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wk | oral | Toxicity Factor Datasets |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | no effect | hepatic porphyrin levels | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wk | oral | Toxicity Factor Datasets |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | no effect | liver weight | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - organ/system effects | 4 wk | oral | Toxicity Factor Datasets |
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | 2.4 (control), 119.0 (PCB 153), 182.0 (PCB 105), 3.3 (PCB 126) mg/kg, wet weight | PCB concentrations in pooled adipose tissue | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-EXP IND - accumulation | 4 wk | oral | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | 21.5-22.6% decrease @ 33 ppm | sperm concentration | Male | Adult | 10/group | 0 and 33 ppm, wet weight (=9-10 mg/kg bw/d) | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | sperm motility | Male | Adult | 10/group | 0 and 33 ppm, wet weight (=9-10 mg/kg bw/d) | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
MIREX | 40.3% decrease @ 8 ppm | sperm concentration | Male | Adult | 5-10/group | 0 and 8 ppm, wet weight (=2.3-2.5 mg/kg bw/d) | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
MIREX | no effect | sperm motility | Male | Adult | 5-10/group | 0 and 8 ppm, wet weight (=2.3-2.5 mg/kg bw/d) | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
AROCLOR 1254, MIREX | 73.3% increase @ 8ppm mirex + 33 ppm Aroclor | semen volume | Male | Adult | 5-10/group | 0 and 8 ppm mirex + 33 ppm Aroclor, wet weight | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
AROCLOR 1254, MIREX | 20.3% decrease @ 8 ppm mirex + 33 ppm Aroclor | sperm concentration | Male | Adult | 5-10/group | 0 and 8 ppm mirex + 33 ppm Aroclor, wet weight | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
AROCLOR 1254, MIREX | no effect | sperm motility | Male | Adult | 5-10/group | 0 and 8 ppm mirex + 33 ppm Aroclor, wet weight | TOX-REPRO - physiology | 62 and 69 d (2 study periods) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, POLYCHLORINATED DIBENZO-P-DIOXINS | increased @ 0.5, 5 ppm | in vitro microsomal breakdown of oestradiol | Both Male and Female | Adult | 4/group | 0, 0.5, 5 ppm, wet wt | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 5 mo | diet | Toxicity Factor Datasets |
AROCLOR 1262, POLYCHLORINATED DIBENZO-P-DIOXINS | increased @ 0.5, 5 ppm | in vitro microsomal breakdown of oestradiol | Both Male and Female | Adult | 4/group | 0, 0.5, 5 ppm, wet wt | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 5 mo | diet | Toxicity Factor Datasets |
AROCLOR 1254, POLYCHLORINATED DIBENZO-P-DIOXINS | increased @ 5 ppm | amount of liver cytoplasmic RNA | Both Male and Female | Adult | 4/group | 0, 5 ppm, wet wt | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 14 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Toxicity Endpoint Type | Type |
---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | TOX-EXP IND - accumulation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CYANIDE, SODIUM | 4.0 mg/kg bw | LD50 | Both Male and Female | Adult | 5/dose | NR | TOX-MORT - dose-response data | single dose | oral | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1248 | 18.5 ug/g (5.1SD), PCBs; 0.10 ug/g (0.03 SD), dieldrin;1.02 ug/g (0.39 SD), DDE @ 3.0 ug/g | mean carcass concentrations, wet wt | Both Male and Female | Adult | 8 pairs/group | 0, 3.0 ug/g, wet wt | TOX-EXP IND - accumulation | 6 mo | diet | Toxicity Factor Datasets |
AROCLOR 1248 | 5% decrease @ 3.0 ug/g | mean eggshell thickness | Female | Adult | 8 pairs/group | 0, 3.0 ug/g, wet wt | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
AROCLOR 1248 | 5.60 ug/g (1.15 SD), PCBs; 0.15 ug/g (0.05 SD), dieldrin; 0.15 ug/g (0.07 SD), DDE @ 3.0 ug/g | mean egg concentrations, wet wt | Female | Adult | 8 pairs/group | 0, 3.0 ug/g, wet wt | TOX-EXP IND - accumulation | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decreased @ 3.0% | body weight | Both Male and Female | Juvenile | 16/group | 0, 0.3, 3.0% diet | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increased @ 3.0% | food consumption | Both Male and Female | Juvenile | 16/group | 0, 0.3, 3.0% diet | TOX-Non-Repro-Sublethal - behavioral effects | 4 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | decreased @ 3.0% | hemoglobin | Both Male and Female | Juvenile | 16/group | 0, 0.3, 3.0% diet | TOX-Non-Repro-Sublethal - organ/system effects | 4 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | no effect | various hematological measurements (packed cell volume, erythrocyte counts, plasma uric acid, plasma alanine aminotransferase) | Both Male and Female | Juvenile | 16/group | 0, 0.3, 3.0% diet | TOX-Non-Repro-Sublethal - organ/system effects | 4 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DICOFOL | 8.11 (fat), 0.28 (liver) ug/g @ 0.3 mg/kg bw/d | sum of geometric mean tissue concentrations (wet wt) of dicofol and metabolites (dichlorobenzophenone, mono-dechlorinated dicofol, dichlorobenzhydrol, DDE) | Female | Adult | 2-4/group | 0, 0.3, 3.0 mg/kg bw/d | TOX-EXP IND - accumulation | 39 d | oral | Toxicity Factor Datasets |
DICOFOL | 82.36 (fat), 4.93 (liver), 1.15 (brain), 0.84 (oviduct) ug/g @ 3.0 mg/kg bw/d | sum of geometric mean tissue concentrations (wet wt) of dicofol and metabolites (dichlorobenzophenone, mono-dechlorinated dicofol, dichlorobenzhydrol, DDE) | Female | Adult | 2-4/group | 0, 0.3, 3.0 mg/kg bw/d | TOX-EXP IND - accumulation | 39 d | oral | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | increased | accumulation in skin | Not Reported | Adult | 4/group | 6.4 ug/g diet, wet wt (1.1 SE) | TOX-EXP IND - accumulation | 7 d | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | no effect | occurence of phosphorus intoxication symptoms | Not Reported | Adult | 4/group | 6.4 ug/g diet, wet wt (1.1 SE) | TOX-Non-Repro-Sublethal - whole animal | 7 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARAQUAT | 22% @ 10 mg/kg, 18% @ 25 mg/kg, 44% @ 60 mg/kg | percent mortality | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-MORT - dose-response data | 10 d | oral | Toxicity Factor Datasets |
PARAQUAT | 86% of control @ 25 mg/kg, 74% of control @ 60 mg/kg | body weight by 10 days of dosing | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-REPRO - development | 10 d | oral | Toxicity Factor Datasets |
PARAQUAT | 11% @ 25 mg/kg, 25% @ 60 mg/kg | percent increase over controls in brain to body weight ratio | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-REPRO - development | 10 d | oral | Toxicity Factor Datasets |
PARAQUAT | 14% @ 25 mg/kg, 18% @ 60 mg/kg | percent increase over controls in liver to body weight ratio | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-REPRO - development | 10 d | oral | Toxicity Factor Datasets |
PARAQUAT | 51% @ 60 mg/kg | percent increase over controls in kidney to body weight ratio | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-REPRO - development | 10 d | oral | Toxicity Factor Datasets |
PARAQUAT | no effect | percent increase over controls in lung to body weight ratio | Not Reported | Juvenile | 11/group | 0,10,25,60 mg/kg bw/d | TOX-REPRO - development | 10 d | oral | Toxicity Factor Datasets |