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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ARSENIC COMPOUNDS, BARIUM COMPOUNDS, CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, SELENIUM COMPOUNDS | increase | incidence of oral deformities at coal ash contaminated site, relative to reference site | Not Reported | Tadpole | Savannah River, Aiken | 575-1048 | mean whole body concn. at contaminated (C) compared to reference (R) site: As, C=48.9 +/- 2.6SE, R=2.5 +/-0.2SE; Ba, C=211.5 +/- 14.9SE, R=81.2 +/- 5.2SE; Cd, C=1.71 +/- 0.5SE, R=0.15 +/- 0.04SE; Cr, C=17.2 +/- 0.5SE, R=1.4 +/- 0.3SE; Cu, C=31.4 +/- 1.5SE | TOX-REPRO - development | NR | site contamination | Toxicity Factor Datasets |
ARSENIC COMPOUNDS, BARIUM COMPOUNDS, CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, SELENIUM COMPOUNDS | increase at contaminated (C) compared to reference (R) site: Arsenic, C=48.9 +/- 2.6SE, R=2.5 +/-0.2SE; Barium, C=211.5 +/- 14.9SE, R=81.2 +/- 5.2SE; Cadmium, C=1.71 +/- 0.5SE, R=0.15 +/- 0.04SE; Chromium, C=17.2 +/- 0.5SE, R=1.4 +/- 0.3SE; Copper, C=31.4 +/- 1.5SE, R=17.5 +/- 6.6SE; Selenium, C=25.70 +/- 3.60SE, R=3.37 +/- 0.09SE. | mean whole body metal concentrations (ppm, dry mass) | Not Reported | Tadpole | Savannah River, Aiken | 3 animals/site | sediment concn. at contaminated (C) compared to reference (R) site: As, C=70.8 +/- 12.5SE, R=<1.0; Ba, C=418.7 +/- 34.0SE, R=11.8 +/- 0.6SE; Cd, C=0.57 +/- 0.05SE, R=0.03 +/- 0.00SE; Cr, C=70.8 +/- 12.5SE, R=<1.0; Cu, C=71.8 +/- 12.3SE, R=<1.0; Se, C=6.21 | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 34.4 ug/l (95% CL: 31.1 - 38.1 ug/l) | LC50 | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | 0, 0.8, 2.0, 4.9, 11.0, 25.4, 64.8, 154.8 ug/l | TOX-MORT - toxicity benchmarks | 21 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 25.1 ug/l | LOAEL, based on mortality but gross spinal deformities also observed | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | 0, 0.8, 2.0, 4.9, 11.0, 25.4, 64.8, 154.8 ug/l | TOX-MORT - toxicity benchmarks | 21 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 11.0 ug/l | NOAEL | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | 0, 0.8, 2.0, 4.9, 11.0, 25.4, 64.8, 154.8 ug/l | TOX-MORT - toxicity benchmarks | 21 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 8.7 ug/l (95% CL: 7.8-9.7 ug/l) | LC50 | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 11.2 ug/l | LOAEL | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 4.0 ug/l | NOAEL | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 5.1 ug/g at 8.7 ug/l | whole body dieldrin concentration (ug/g, wet wt.) at the LC50 | Not Reported | Tadpole | Not Reported | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 6.0 ug/g at 11.2 ug/l | whole body dieldrin concentration (ug/g, wet wt.) | Not Reported | Tadpole | Not Reported | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 2.0 ug/g at 4.0 ug/l | whole body dieldrin concentration (ug/g, wet wt.) | Not Reported | Tadpole | Not Reported | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 360 - 540 | range of bioconcentration factors; calculated by dividing the whole body tissue dieldrin concentration by water dieldrin concentration | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 36,000 - 54,000 | range of lipid bioconcentration factors; calculated by dividing the whole body bioconcentration values x 100 by percent lipid | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 2.2, 4.0, 11.2, 46.5, 179.9 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 30.3 ug/l (95% CL: 26.2 - 35.2 ug/l) | LC50 | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 52.3 ug/l | LOAEL | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 12.3 ug/l | NOAEL | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-MORT - toxicity benchmarks | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 12.0 ug/g at 30.3 ug/l | whole body dieldrin concentration (ug/g, wet wt.) at the LC50 | Not Reported | Tadpole | Not Reported | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 19.0 ug/g at 52.3 ug/l | whole body dieldrin concentration (ug/g, wet wt.) | Not Reported | Tadpole | Not Reported | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 0.5 ug/g at 12.3 ug/l | whole body dieldrin concentration (ug/g, wet wt.) at the NOAEL | Not Reported | Tadpole | Not Reported | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 360 - 900 | range of bioconcentration factors; calculated by dividing the whole body tissue dieldrin concentration by water dieldrin concentration | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
DIELDRIN | 36,000 - 90,000 | range of lipid bioconcentration factors; calculated by dividing the whole body bioconcentration values x 100 by percent lipid | Not Reported | Tadpole | 20 animals/replicate; 4 replicates/dose | 0, 1.0, 3.8, 12.3, 52.3, 182.0 ug/l | TOX-EXP IND - accumulation | 4 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | no effect | preference/avoidance behavior and spontaneous locomotor activity | Not Reported | Tadpole | 8 animals/dose | 0, 500, 625, 750, 1000 ug/l | TOX-REPRO - behavior | 6 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MEXACARBATE | 283 - 800 mg/kg | LD50, estimated | Male | Not Reported | 14 | NR | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 7.84 ppm femur at 120 ppm; 16.60 ppm femur at 212 ppm; 18.44 ppm femur at 448 ppm | mean lead concentration in femur | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | no effect | packed cell volume, hemoglogin concentration, erythrocyte counts | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIMETHYLMERCURY | no effect | eggshell thickness | Female | Adult | Not Reported | 0, 10 ppm | TOX-REPRO - physiology | 3 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease | eggshell thickness | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | decrease | Calcium ATPase activity of shell gland | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | decrease | carbonic anhydrase activity of shell gland | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | calcium concentration in blood | Female | Adult | 8/group | 6 mg/kg bw/d | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at all doses (15.1-29.2%) | eggshell thickness | Female | Adult | 2-5 pairs/dose | 0, 0.3, 3, 6, 10 ppm (wet wt) | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 5.53 mg/kg egg (wet wt) | mean DDE concentration in eggs (pooled analyses) | Both Male and Female | Embryo | N. Niagra Peninsula, Ontario | 10 eggs | 0.009 mg/kg plant; 0.343 mg/kg soil; 0.605 mg/kg worm; 0.016 mg/kg vole | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | eggshell thickness | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-REPRO - physiology | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | lead concentration in eggshell | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | 62.0 ppm tibia, 13.5 ppm humeri at 50 ppm | lead concentrations in bones | Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | increased at 2, 3 mg/kg bw | abnormal posture, ataxia, paresis | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - behavioral effects | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | increase at 3 mg/kg bw | mortality rate 2 hr post-dose | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets |
METHYLPARATHION | decrease at 2, 3 mg/kg bw | cloacal temperature | Both Male and Female | Adult | 5/dose | 0, 0.375, 1.0, 2.0, 3.0 mg/kg bw | TOX-Non-Repro-Sublethal - whole animal | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MEXACARBATE | 3.0 mg/kg | LD50 | Both Male and Female | Not Reported | 12 | NR | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MEXACARBATE | 2.83 mg/kg | LD50 | Both Male and Female | Not Reported | 8 | NR | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |