TRAMADOL HYDRCHLORIDE |
No effect |
Agitation-sedation score |
B |
Adult |
|
12 |
0, 5, 15, 30 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
Oral gavage |
Toxicity Factor Datasets |
BUTORPHANOL TARTRATE |
Increased from baseline |
Thermal threshold of foot |
F |
Adult |
|
15 |
0 (saline), 1, 3, 6 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
IM injection |
Toxicity Factor Datasets |
BUTORPHANOL TARTRATE |
Decreased from baseline |
Thermal threshold of foot |
M |
|
|
15 |
0 (saline), 1, 3, 6 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
IM injection |
Toxicity Factor Datasets |
BUTORPHANOL TARTRATE |
See citation |
Agitation-sedation score |
M |
Adult |
|
15 |
0 (saline), 1, 3, 6 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
IM injection |
Toxicity Factor Datasets |
BUTORPHANOL TARTRATE |
No effect |
Agitation-sedation score |
F |
Adult |
|
15 |
0 (saline), 1, 3, 6 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
IM injection |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
6377 ng/g ww |
Fat concentration |
B |
Adult |
|
34 |
116 µg/d |
TOX-EXP IND - accumulation |
21 d |
Dietary |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
384 ng/g ww |
Liver concentration |
B |
Adult |
|
34 |
116 µg/d |
TOX-EXP IND - accumulation |
21 d |
Dietary |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
1583 ng/g ww |
Plasma concentration |
B |
Adult |
|
34 |
116 µg/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
21 d |
Dietary |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
194 ng/g ww |
Plasma concentration |
B |
Adult |
|
34 |
116 µg/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
21 d |
Dietary |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
14 d |
Half-life |
B |
Adult |
|
34 |
116 µg/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
21 d |
Dietary |
Toxicity Factor Datasets |
2,2',3,3',4,4',5,5',6,6'-DECABROMODIPHENYL ETHER (BDE-209) |
See citation |
Plasma/organ PBDE congener concentrations |
B |
Adult |
|
34 |
116 µg/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
21 d |
Dietary |
Toxicity Factor Datasets |
PCB |
5.4-31.5 ppm ww |
Plasma concentration |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
18 |
10 mg/kg body weight/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
|
|
Toxicity Factor Datasets |
PCB |
See citation |
Plasma corticosterone concentration |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
18 |
10 mg/kg body weight/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
|
|
Toxicity Factor Datasets |
PCB |
Weaker increase |
Corticosterone secretion from handling |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
18 |
10 mg/kg body weight/d |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
|
|
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Mean copulations |
M |
Adult |
McGill University |
21 |
In ovo: 0, low, high; parents exposed via diet: 0, low, high |
TOX-REPRO - behavior |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Clutch size |
B |
Adult |
McGill University |
21 |
|
TOX-REPRO - reproductive success |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Egg weight |
B |
Embryo |
McGill University |
21 |
|
TOX-REPRO - reproductive success |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Egg volume |
B |
Embryo |
McGill University |
21 |
|
TOX-REPRO - reproductive success |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
% fertility |
B |
Embryo |
McGill University |
21 |
|
TOX-REPRO - reproductive success |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Chitter call |
M |
Adult |
McGill University |
21 |
|
TOX-REPRO - behavior |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Decreased |
Whine call |
F |
Adult |
McGill University |
21 |
|
TOX-REPRO - behavior |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
PBDE MIXTURE |
Increased |
Flight display |
M |
Adult |
McGill University |
21 |
|
TOX-REPRO - behavior |
|
In ovo & via parental exposure |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Unpaired exposed: increased mass |
Testes weight |
M |
Adult |
|
22 |
Breeding & unpaired males: 0, 0.51 µg/kg/d |
TOX-REPRO - physiology |
Breeding males: 3 w pre-pairing through courtship; Unpaired males: 3 w |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Unpaired exposed: increased |
Seminiferous tubules, elongated spermatids |
M |
Adult |
|
22 |
Breeding & unpaired males: 0, 0.51 µg/kg/d |
TOX-REPRO - physiology |
Breeding males: 3 w pre-pairing through courtship; Unpaired males: 3 w |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Unpaired exposed: increased |
Plasma testosterone |
M |
Adult |
|
22 |
Breeding & unpaired males: 0, 0.51 µg/kg/d |
TOX-REPRO - physiology |
Breeding males: 3 w pre-pairing through courtship; Unpaired males: 3 w |
Dietary |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
Decreased |
Testosterone during mate egg laying |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
No effect |
T3 |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
No effect |
T4 |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
Increased |
Perivitelline layer sperm count |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
Increased |
Gonadosomatic Index |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
Increased |
Testes weight |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
PBDE TECHNICAL MIXTURE, DE-71 |
Increased |
Seminiferous tubules containing lumen |
M |
Adult |
Avian Science and
Conservation Centre at McGill University |
21 |
In ovo through maternal transfer: 3, 289, 1131 ng/g ww |
TOX-REPRO - physiology |
|
In ovo |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
No effect |
Body mass |
B |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-Non-Repro-Sublethal - whole animal |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Decreased |
Active behaviors |
B |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-Non-Repro-Sublethal - behavioral effects |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Decreased |
Courtship calls |
B |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-REPRO - behavior |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Decreased |
Nest temperature |
B |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-REPRO - behavior |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Decreased |
Nest box inspection |
M |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-REPRO - behavior |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Increased |
Nest box inspection |
F |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-REPRO - behavior |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
HEXABROMOCYCLODODECANE (HBCDD) |
Increased |
Solicitation of food from males |
F |
Adult |
McGill University |
30 |
0.51 µg/g body weight/d |
TOX-Non-Repro-Sublethal - whole animal |
4 w prior to pairing through incubation |
Dietary |
Toxicity Factor Datasets |
1,2-DIBROMO-4-(1,2-DIBROMOETHYL)CYCLOHEXANE (DBE-DBCH - FORMERLY TBECH) |
Below detection limit |
Plasma, liver, kidney, fat, egg concentrations |
B |
Adult |
McGill University |
46 pairs |
0.239 ng/g/d |
TOX-EXP IND - accumulation |
82 d |
Dietary |
Toxicity Factor Datasets |