SULFUR DIOXIDE |
See citation |
Plasma FT3 |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
Decreased |
Plasma FT4 |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
Decreased |
Plasma TT4 |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
Decreased |
Plasma T4 |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
See citation |
Thyroid histology |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - organ/system effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
No effect |
Hepatic T4-ORD activity |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
SULFUR DIOXIDE |
No effect |
Plasma TT3 |
F |
Adult |
|
17 |
Mixutre: 0.6 ppm benzene, 1 ppm toluene, 2 ppm nitrogen dioxide, 5.6 ppm sulfur dioxide |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
1.4 h/day, 5d/w, 18 d |
Airborne |
Toxicity Factor Datasets |
COPPER (elemental) |
Increased |
Liver concentration |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - organ/system effects |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Blood concentration |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
Increased |
Metallotionein |
M |
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Metallotionein |
F |
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
See citation |
Pancreas histology |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - organ/system effects |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Body mass |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Hemoglobin |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Methemoglobin |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Kidney concentration |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Plasma biochemistry |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
COPPER (elemental) |
No effect |
Hematocrit |
|
Adult |
|
26 |
5 mg/g body mass |
TOX-Non-Repro-Sublethal - whole animal |
9 doses |
Oral gavage |
Toxicity Factor Datasets |
PBDE MIXTURE |
Increased |
Plasma TT4 |
F |
Nestling |
Environment Canada |
|
In ovo, 3, 289, 11301 ng/g ww/d parent diet |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
Daily 3 w before parental pairing through incubation |
In ovo |
Toxicity Factor Datasets |
PBDE MIXTURE |
Increased |
Plasma TT3 |
F |
Nestling |
Environment Canada |
|
In ovo, 3, 289, 11301 ng/g ww/d parent diet |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
Daily 3 w before parental pairing through incubation |
In ovo |
Toxicity Factor Datasets |
PBDE MIXTURE |
No effect |
Plasma TT4 |
M |
Nestling |
Environment Canada |
|
In ovo, 3, 289, 11301 ng/g ww/d parent diet |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
Daily 3 w before parental pairing through incubation |
In ovo |
Toxicity Factor Datasets |
PBDE MIXTURE |
No effect |
Plasma TT3 |
M |
Nestling |
Environment Canada |
|
In ovo, 3, 289, 11301 ng/g ww/d parent diet |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
Daily 3 w before parental pairing through incubation |
In ovo |
Toxicity Factor Datasets |
PCB |
Increased |
Flight |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-Non-Repro-Sublethal - behavioral effects |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
PCB |
Increased |
Sexual behaviors |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-REPRO - behavior |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
PCB |
No effect |
Flight |
F |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-Non-Repro-Sublethal - behavioral effects |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
PCB |
No effect |
Copulation frequency |
B |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-REPRO - behavior |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
PCB |
No effect |
Sex hormones |
M |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-REPRO - physiology |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
PCB |
No effect |
Sex hormones |
F |
Adult |
Avian Science and Conservation Centre of McGill University |
50 pairs |
4.85 mg/g |
TOX-REPRO - physiology |
Daily 3 w before pairing |
Dietary |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
See citation |
Plasma concentration |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-EXP IND - accumulation |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
0.948 |
Bioavailability |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
92.1 m |
Half-life (IM) |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
105.5 m |
Half-life (IV) |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
No effect |
Food intake |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - whole animal |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
BUPRENORPHINE HYDROCHLORIDE |
15-30 m |
Sedation set-in, mild-moderate |
B |
Adult |
|
13 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - whole animal |
2 doses |
IM injection followed by IV 2 w later |
Toxicity Factor Datasets |
HYDROMORPHONE HYDROCHLORIDE |
112.1 mg/mL at 5 m post dose |
Plasma concentration |
B |
Adult |
|
12 |
0.6 mg/kg |
TOX-EXP IND - accumulation |
2 doses |
IM injection followed by IV 1 m later |
Toxicity Factor Datasets |
HYDROMORPHONE HYDROCHLORIDE |
1.26 h |
Half-life (IM) |
B |
Adult |
|
12 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
2 doses |
IM injection followed by IV 1 m later |
Toxicity Factor Datasets |
HYDROMORPHONE HYDROCHLORIDE |
1.25 h |
Half-life (IV) |
B |
Adult |
|
12 |
0.6 mg/kg |
TOX-Non-Repro-Sublethal - cellular/biochemical effects |
2 doses |
IM injection followed by IV 1 m later |
Toxicity Factor Datasets |
TRAMADOL HYDRCHLORIDE |
Increased |
Thermal threshold of foot |
B |
Adult |
|
12 |
0, 5, 15, 30 mg/kg |
TOX-Non-Repro-Sublethal - behavioral effects |
Single dose |
Oral gavage |
Toxicity Factor Datasets |