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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | no effect | histological changes to nervous system, bones, feathers, feather follicles, claws and scaled skin versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - whole animal | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased in birds that died, and in some 40 ppm survivors | histological changes to skin (loss of fat), muscle, liver, pancreas, kidney, lymph nodes, spleen, seminiferous tubules | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - whole animal | 16 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 80 ppm | mortality versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-MORT - dose-response data | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 80 ppm | feed consumption over time versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - behavioral effects | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 40 and 80 ppm | body weight over exposure period versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - whole animal | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased in birds that died | incidence of macroscopic abnormalities versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - organ/system effects | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 40 ppm | incidence of macroscopic abnormalities of muscles, claws and feathers versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - whole animal | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased in birds that died | mean weights of heart, spleen, pancreas, testis versus controls | Male | Adult | 21/dose | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-Non-Repro-Sublethal - organ/system effects | 16 wks | diet | Toxicity Factor Datasets |
SELENOMETHIONINE | 33(7) ppm @ 10 ppm Se, 49(9) ppm @ 20 ppm Se, 87(11) ppm @ 40 ppm Se, 99(9) ppm in birds that died | mean (SE) dry wt concentrations of selenium in liver | Male | Adult | 10-25 | 0, 10, 20, 40, 80 ppm Se in diet, wet wt | TOX-EXP IND - accumulation | 16 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al or 0.277 mol sulfate/kg | growth of tibia versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | 0, 0.1% Al (low Al), 0.5% Al (high Al), 0.056 mol sulfate/kg (low acid), 0.277 mol sulfate/kg (high acid) in diet | TOX-Non-Repro-Sublethal - whole animal | 15 d | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE, SULFURIC ACID | reduced @ 0.5% Al | tibial dry weight, and ash and calcium content versus ad libidum controls | Both Male and Female | Juvenile | 8 birds/treatment | 0, 0.1% Al (low Al), 0.5% Al (high Al), 0.056 mol sulfate/kg (low acid), 0.277 mol sulfate/kg (high acid) in diet | TOX-Non-Repro-Sublethal - whole animal | 15 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | body weight versus controls | Both Male and Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-Non-Repro-Sublethal - whole animal | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 900 ppm B | liver weight versus 450 ppm B group | Male | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-Non-Repro-Sublethal - organ/system effects | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | hemoglobin concentrations versus controls | Male | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-Non-Repro-Sublethal - cellular/biochemical effects | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | no effect | onset of egg laying, eggshell thickness, frequency of embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | egg weight, hatching success, egg fertility versus controls | Both Male and Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 7 ppm Se | body weight versus controls | Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-Non-Repro-Sublethal - whole animal | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | no effect due to added Se | liver weight, hemoglobin concentrations, hematocrit versus controls | Both Male and Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | no effect due to added Se | onset of egg laying, eggshell thickness, egg weight, egg fertility, embryo deformities versus controls | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 7 ppm Se | hatching success versus controls | Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | decreased @ 900 ppm B | total SH, liver protein, sorbitol dehyrogenase versus controls | Both Male and Female | Juvenile | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - development | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 900 ppm B | body weight and growth at 0, 7,and 14 days post-hatch versus controls | Both Male and Female | Juvenile | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - development | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 7 ppm Se | body weight and weight gain at 7 and 14 days post-hatch versus 3.5 ppm Se group | Both Male and Female | Juvenile | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - development | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | increased @ 3.5 ppm Se | survival between 7 and 14 days post-hatch versus controls | Both Male and Female | Juvenile | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | reduced @ 7 ppm | duckling production versus 3.5 ppm Se group | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-REPRO - reproductive success | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | 4.6 (0.18) ppm B @ 450 ppm B; 8.5 (0.34) ppm B @ 900 ppm B; 3.7 (0.16) ppm Se @ 3.5 ppm Se; 6.2 (0.27) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in liver | Both Male and Female | Adult | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-EXP IND - accumulation | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
BORIC ACID, SELENOMETHIONINE | 6.5 (0.25) ppm B @ 450 ppm B; 11 (0.4) ppm B @ 900 ppm B; 3.5 (0.10) ppm Se @ 3.5 ppm Se; 7.1 (0.28) ppm Se @ 7 ppm | mean (SE) wet wt concentrations of B and Se in egg | Both Male and Female | Both Adults and Juveniles | 14 pairs/treatment | 0, 450 ppm B, 900 ppm B, with 0, 3.5, or 7 ppm Se | TOX-EXP IND - accumulation | prior to and through reproduction (until ducklings were 14 d) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | no effect | body weight versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | reduced @ 828 ug/g | hemoglobin concentrations versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | reduced @ all doses | delta aminolevulinic acid dehydratase activity versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | increased @ 414, 828 ug/g | occurrence of intranuclear inclusion bodies in kidneys versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | increased @ 828 ug/g | occurrence of lead poisoning signs versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | increased @ all doses | protoporphyrin levels in blood versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 4.6(0.66) ppm @ 103 ug/g Pb; 9.3(0.82) ppm @ 207 ug/g Pb; 12(1.3) ppm @ 414 ug/g Pb; 28(4.6) ppm @ 828 ug/g Pb | mean(SE) wet wt concentrations of lead in liver | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | no effect | body weight versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | reduced @ 624 and 1284 ug/g | delta aminolevulinic acid dehydratase activity and hemoglobin concentrations | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | increased @ 642 and 1284 ug/g | protoporphyrin versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | reduced @ 1284 ug/g | hematocrit versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Toxicity Endpoint Type | Type |
---|---|---|---|---|---|---|
STRYCHNINE, ZINC PHOSPHIDE | review | summaries of sublethal effects due to organochlorine, anticholinesterase, anticoagulant, strychnine pesticides | Not Reported | Not Reported | TOX-Non-Repro-Sublethal - whole animal | Toxicity Factor Datasets |
Endpoint Value | Endpoint Description | Toxicity Endpoint Type | Type |
---|---|---|---|
reduced @ 900 ppm B | duckling production versus controls | TOX-REPRO - reproductive success | Toxicity Factor Datasets |