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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | daily survival rates on uncontaminated versus contaminated sites | Not Reported | Adult | Rocky Mountain Arsenal National Wildlife Refuge | 9 birds on contaminated sites; 11 birds on uncontaminated sites | 0.18 ppm (uncontaminated), 1.15 ppm (contaminated) in soil within adult home ranges | TOX-MORT - mortality in the field | NR | habitat contamination | Toxicity Factor Datasets |
DIELDRIN | 0.07 +/- 0.03 ppm (uncontaminated site); 0.34 +/- 0.21 ppm (contaminated site) | mean (+/- SE) concentrations in plasma | Not Reported | Adult | Rocky Mountain Arsenal National Wildlife Refuge | 2 birds on contaminated sites; 5 birds on uncontaminated sites | 0.18 ppm (uncontaminated), 1.15 ppm (contaminated) in soil within adult home ranges | TOX-EXP IND - accumulation | NR | habitat contamination | Toxicity Factor Datasets |
DIELDRIN | 0.01 +/- 0.003 ppm (uncontaminated site); 0.22 +/- 0.03 ppm (contaminated site) | mean (+/- SE) concentrations in plasma | Not Reported | Juvenile | Rocky Mountain Arsenal National Wildlife Refuge | 6 birds on contaminated sites; 10 birds on uncontaminated sites | 0.18 ppm (uncontaminated), 1.15 ppm (contaminated) in soil within adult home ranges | TOX-EXP IND - accumulation | NR | habitat contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | 6.96 mg/kg bw (2.66-8.96 95% CI) | 24 hour median lethal dose | Female | Adult | 6 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 6.46 mg/kg bw (5.19-7.69 95% CI) | 24 hour median lethal dose | Male | Adult | 4-5 birds/dose | 0, 2, 4, 5.2, 6.1, 7.1, 8.0, 9.1 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 3.90 mg/kg bw (3.24-4.69 95% CI) | 24 hour median lethal dose | Female | Adult | 4-5 birds/dose | 0, 1.0, 2.0, 3.4, 4.0, 6.5 mg/kg bw (pelletized) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | reduced above 6.2 mg/kg bw | body weight versus controls | Not Reported | Adult | 4-5 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-Non-Repro-Sublethal - whole animal | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | increased above 4.3 mg/kg bw | liver to body weight ratio versus controls | Not Reported | Adult | 4-5 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | positive relationship | relation between liver to body weight ratio and dose | Male | Adult | 4-5 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | positive correlation | relation between dose and frequency and severity of hepatic and kidney lesions | Not Reported | Adult | 4-5 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-Non-Repro-Sublethal - organ/system effects | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | positive correlation | P4 concentration in fat versus dose | Male | Adult | 4-5 birds/dose | 0, 1.0, 2.0, 3.4, 4.0, 6.5 mg/kg bw (pelletized) | TOX-EXP IND - accumulation | single | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | increased @ 484.2, 972.0 ug/g diet (nominal concentrations) | incidence of mortality versus controls | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | increased @ 235.0, 484.2, 972.0 ug/g (nominal concentrations) | incidence of clinical signs versus controls | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | decreased @ 484.2, 972.0 ug/g (nominal concentrations) | food consumption during first week of treatment versus controls | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-Non-Repro-Sublethal - behavioral effects | 4 wks | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | decreased @ 235.0, 484.2, 972.0 ug/g (nominal concentrations) | body weight versus controls | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 91.1 ug/g | No Observable Effect Level, based on mortality, pathology, clinical signs | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-MORT - toxicity benchmarks | 4 wks | diet | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 679.8 ug/g (194.3-442.6 95% CI ) | LC50 | Both Male and Female | Adult | 5 males, 5 females/dose | 0, 17.3-19.7, 72.0-79.1, 243.3-260, 461-498.3, 900.7-1023.3 ug/g diet (range in measured concentrations over 4 wks) | TOX-MORT - toxicity benchmarks | 4 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DIELDRIN, OXYCHLORDANE, POLYCHLORINATED BIPHENYLS | positive correlation | relationships between EROD activity and dieldrin concentrations | Female | Adult | Bloomington | 5 birds/timepoint (timepoints = 0,10,20,32,42,52,59,70,80,90,100 days) | in ppm wet wt, carcass, after 100 d exposure: 0.08 (dieldrin); 0.18 (oxychlordane); 0.09 (DDE), 16.56 (total PCBs) | TOX-EXP IND - biomarkers | up to 100 d | habitat contamination | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, OXYCHLORDANE, POLYCHLORINATED BIPHENYLS | positive correlation | relationship between BROD, PROD, and EROD activities and total PCB, oxychlordane, and TEQs concentrations | Female | Adult | Bloomington | 5 birds/timepoint (timepoints = 0,10,20,32,42,52,59,70,80,90,100 days) | in ppm wet wt, carcass, after 100 d exposure: 0.08 (dieldrin); 0.18 (oxychlordane); 0.09 (DDE), 16.56 (total PCBs) | TOX-EXP IND - biomarkers | up to 100 d | habitat contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased @ 100, 250, 500 mg/kg bw | thyroid wt/body wt and liver wt/body wt ratios versus controls | Male | Adult | 6-12/dose | 0,4,20,100,250,500 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | twice/wk for 5 wks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | increased @ 20,100, 250, 500 mg/kg bw | hepatic microsomal EROD and PROD activities versus controls | Male | Adult | 6-12/dose | 0,4,20,100,250,500 mg/kg bw | TOX-EXP IND - biomarkers | twice/wk for 5 wks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | decreased @ 20, 100, 250, 500 mg/kg bw | plasma triiodothyronine concentrations versus controls | Male | Adult | 6-12/dose | 0,4,20,100,250,500 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | twice/wk for 5 wks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | leukocyte counts, plasma biochemistry, corticosterone concentration versus controls | Male | Adult | 6-12/dose | 0,4,20,100,250,500 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | twice/wk for 5 wks | oral gavage | Toxicity Factor Datasets |
AROCLOR 1254 | increased @ 250, 500 mg/kg bw | lymphocyte proliferation to PHA versus controls | Male | Adult | 6-12/dose | 0,4,20,100,250,500 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | twice/wk for 5 wks | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | reproductive success or nest attentiveness versus controls | Both Male and Female | Adult | 22 pairs | mean(SE) of 4 samples: 26.3(0.2) ppm, wet wt, in diet | TOX-REPRO - reproductive success | at least one month | diet | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | body and liver weights of parents and offspring versus controls | Both Male and Female | Both Adults and Juveniles | 22 pairs | mean(SE) of 4 samples: 26.3(0.2) ppm, wet wt, in diet | TOX-Non-Repro-Sublethal - organ/system effects | at least one month | diet | Toxicity Factor Datasets |
AROCLOR 1254 | 55-65 ppm | range of wet wt concentrations of Aroclor 1254 in adult carcasses | Both Male and Female | Adult | 22 pairs | mean(SE) of 4 samples: 26.3(0.2) ppm, wet wt, in diet | TOX-EXP IND - accumulation | at least one month | diet | Toxicity Factor Datasets |
AROCLOR 1254 | 29.5(1.4) ppm | mean(SE) wet wt concentrations of Aroclor 1254 in carcasses of 3 week old ducklings | Not Reported | Juvenile | 10 | mean(SE) of 4 samples: 26.3(0.2) ppm, wet wt, in diet | TOX-EXP IND - accumulation | at least one month | diet | Toxicity Factor Datasets |
AROCLOR 1254 | 23.3(1.0) ppm | mean(SE) wet wt concentrations of Aroclor 1254 in eggs | Not Reported | Embryo | 19 eggs | mean(SE) of 4 samples: 26.3(0.2) ppm, wet wt, in diet | TOX-EXP IND - accumulation | at least one month | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | increased @ 50, 90 percent | population density 2 years post-spray versus controls | Not Reported | Not Reported | near Lakota (48deg03'N, 98deg21'W) | 3-6 sample wetlands/treatment | 0, 50, 70, or 90 percent of wetland sprayed | TOX-Non-Repro-Sublethal - indirect effects | 2 yrs | spray application to habitat | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM | figure/table | figures and tables of selenium concentration over time (% of administered dose) | Female | Adult | Not Reported | 0.21-0.24 ug/kg bw | TOX-EXP IND - accumulation | single | intravenous | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EMAMECTIN BENZOATE | no effect | numbers of eggs laid and hatched, eggshell thickness, and 14-day hatchling survival versus controls | Both Male and Female | Both Adults and Juveniles | 16 pairs/group | 0, 4, 8, 20, 40 ppm in diet | TOX-REPRO - reproductive success | 20 weeks | diet | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | no effect | mortality versus controls | Both Male and Female | Adult | 16 pairs/group | 0, 4, 8, 20, 40 ppm in diet | TOX-MORT - dose-response data | 20 weeks | diet | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | no effect | incidence of signs of toxicity and body weight versus controls | Both Male and Female | Adult | 16 pairs/group | 0, 4, 8, 20, 40 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 20 weeks | diet | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | no effect | feed consumption versus controls | Both Male and Female | Adult | 16 pairs/group | 0, 4, 8, 20, 40 ppm in diet | TOX-Non-Repro-Sublethal - behavioral effects | 20 weeks | diet | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | no effect | microscopic changes to brain, spinal cord, or peripheral nerves versus controls | Both Male and Female | Adult | 16 pairs/group | 0, 4, 8, 20, 40 ppm in diet | TOX-Non-Repro-Sublethal - organ/system effects | 20 weeks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EMAMECTIN BENZOATE | 76 mg/kg bw, 56-102 (95% CI) | acute oral LD50 | Both Male and Female | Adult | 10/dose | 0, 25, 50, 100, 200, 400, 800 mg/kg bw; avg measured concentration was 107% of nominal | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | < 25 mg/kg bw | no-observed-effect level, based on body weight loss | Both Male and Female | Adult | 10/dose | 0, 25, 50, 100, 200, 400, 800 mg/kg bw; avg measured concentration was 107% of nominal | TOX-Non-Repro-Sublethal - whole animal | single | oral gavage | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | 570 ppm diet, 391-915 (95% CI) | dietary LC50 | Both Male and Female | Juvenile | 10/dose | 0, 10, 20, 40, 80, 163, 327, 654, 1308 mg/kg bw; avg measured concentration was 108% of nominal | TOX-MORT - toxicity benchmarks | 5 d | diet | Toxicity Factor Datasets |
EMAMECTIN BENZOATE | 20 ppm diet | no-observed-effect concentration (NOEC), based on reduced feed consumption and weight gain | Both Male and Female | Juvenile | 10/dose | 0, 10, 20, 40, 80, 163, 327, 654, 1308 mg/kg bw; avg measured concentration was 108% of nominal | TOX-Non-Repro-Sublethal - whole animal | 5 d | diet | Toxicity Factor Datasets |