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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 36 (cholineserase only), 108 ug/g | plasma alkaline phosphatase, aspartate aminotransferase, cholinesterase activities, and uric acid | Not Reported | Embryo | 12/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36, 108 ug/g | embryo weight and length, % normal survivors versus controls | Not Reported | Embryo | 12/group | 0,12,36,108 ug/g egg | TOX-REPRO - development | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12 ug/g (48%), 36 ug/g (29%), 108 ug/g (0%) | % surviving to hatch versus controls | Not Reported | Hatchling | 12/group | 0,12,36,108 ug/g egg | TOX-MORT - dose-response data | single | application to egg surface | Toxicity Factor Datasets |
EPN | decreased @ 12, 36 ug/g | plasma cholinesterase activity, hemoglobin and uric acid content | Not Reported | Hatchling | 12/group | 0,12,36,108 ug/g egg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | application to egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CYANIDE | decreased @ all doses | ATP levels in liver and brain tissues versus controls | Female | Adult | 5/treatment | 0,0.25,0.5,1.0,2.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | no effect | ATP levels in heart versus controls | Female | Adult | 5/treatment | 0,0.25,0.5,1.0,2.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | increased | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in brain versus controls | Female | Adult | 5/treatment | 0,1.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | no effect | rhodanese and 3-mercaptopyruvate sulfurtransferase activities in liver and heart versus controls | Female | Adult | 5/treatment | 0,1.0 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CYANIDE | increased @ 1, 2 mg/kg bw | serum creatine kinase activity versus controls | Female | Adult | at least 5 determinations/group | 0,1,2 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
CYANIDE | decreased @ 0.5,1,2 mg/kg bw | respiratory control ratios in heart, liver and brain versus controls | Female | Adult | at least 5 determinations/group | 0,0.5,1,2 mg/kg bw (as KCN) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | no effect | body weight and food consumption versus controls | Both Male and Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-Non-Repro-Sublethal - whole animal | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | no effect | incidence of lead poisoning tissue lesions versus controls | Both Male and Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-Non-Repro-Sublethal - organ/system effects | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 112.27 (+/- 44.27); lead-iron: 32.65 (+/- 16.58) ppm, wet wt | lead concentration in bone (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 10.22 (+/- 1.46); lead-iron: 3.38 (+/- 0.56) ppm, wet wt | lead concentration in bone (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 0.71 (+/- 0.25); lead-iron: 0.31 (+/- 0.06) ppm, wet wt | lead concentration in blood (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 0.49 (+/-0.10); lead-iron: 0.23 (+/- 0.04) ppm, wet wt | lead concentration in blood (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 3.53 (+/- 1.43); lead-iron: 1.42 (+/- 0.65) ppm, wet wt | lead concentration in kidneys (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 1.02 (+/- 0.22); lead-iron: 0.75 (+/- 0.10) ppm, wet wt | lead concentration in kidneys (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 1.15 (+/- 0.29); lead-iron: 0.32 (+/- 0.05) ppm, wet wt | lead concentration in liver (mean +/- SE) | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | lead only: 0.58 (+/- 0.19); lead-iron: 0.25 (+/- 0.02) ppm, wet wt | lead concentration in liver (mean +/- SE) | Male | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | decreased with increasing lead in bone | number of eggs laid | Female | Adult | control=2 F, 4 M; treatment=6 M-F pairs/group | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-REPRO - reproductive success | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased with lead shot (egg contents: 0.50 +/-0.06; egg shell: 2.80 +/-0.25 ppm, wet wt) and lead-iron shot (egg shell: 1.42 +/-0.26 ppm, wet wt) | lead in egg contents and shell (mean +/- SE) versus controls | Female | Adult | control=10 eggs; treatment=20 eggs | 0, 1 #four lead shot, or 1 #four iron-lead shot (47.5% lead) | TOX-EXP IND - accumulation | single | intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | decreased @ 3,000, 30,000 ppm, incubation day 3 exposure | embyronic length and weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 300, 3,000, 30,000 ppm lead in solution | TOX-REPRO - development | single 30 second exposure | egg immersion in solution | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE | decreased @ all doses | embryo length or weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 50, 500, 5,000 ppm mercury in solution | TOX-REPRO - development | single 30 second exposure | egg immersion in solution | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE | decreased @ 5,000 ppm, incub. day 3 exposure | embryo survival through day 18 of incubation and % of survivors that were normal versus controls | Not Reported | Embryo | 30 eggs/group | 0, 50, 500, 5,000 ppm mercury in solution | TOX-REPRO - development | single 30 second exposure | egg immersion in solution | Toxicity Factor Datasets |
FUEL OILS | decreased @ 0.5, 5 ul/egg on incubation day 3 or 8 | embryo survival to day 18 of incubation and % of survivors that were normal versus controls | Not Reported | Embryo | 30 eggs/group | 0, 0.5, 5 ul RDCO oil/egg | TOX-REPRO - development | single | topical application | Toxicity Factor Datasets |
FUEL OILS | decreased @ 0.5 ul/egg, incubation day 3 or 8 exposure | embyronic length and weight by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 0.5, 5 ul RDCO oil/egg | TOX-REPRO - development | single | topical application | Toxicity Factor Datasets |
FUEL OILS | decreased @ 2% emulsion, incubation day 8 exposure | embryo survival through day 18 of incubation versus controls | Not Reported | Embryo | 30 eggs/group | 0, 0.2%, 2% aqueous spray oil emulsion | TOX-REPRO - development | single 30 second exposure | egg immersion | Toxicity Factor Datasets |
ACETONE | decreased @ 100% solution, incubation days 3 or 8 exposure | embryo weight and length by incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 10%, 100% solution | TOX-REPRO - development | single 30 second exposure | egg immersion | Toxicity Factor Datasets |
ACETONE | decreased @ 100% solution, incubation days 3 or 8 exposure | embryo survival through incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 10%, 100% solution | TOX-REPRO - development | single 30 second exposure | egg immersion | Toxicity Factor Datasets |
N-BUTYL ALCOHOL | 0 survival @ 100% solution, incubation days 3 or 8 exposure | embryo survival through incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 10%, 100% solution | TOX-REPRO - development | single 30 second exposure | egg immersion | Toxicity Factor Datasets |
XYLENE | no effect | embryo survival, size, and incidence of abnormalities through incubation day 18 versus controls | Not Reported | Embryo | 30 eggs/group | 0, 1%, 10% solution | TOX-REPRO - development | single 30 second exposure | egg immersion | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD NITRATE | decreased @ 25 ppm/3 wks, 5 ppm/12 wks | delta-aminolevulinic acid dehydratase activity in blood versus controls | Male | Adult | 20/dose; 5/dose x time group | 0, 1, 5, 25 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3, 6, 9, or 12 wks | diet | Toxicity Factor Datasets |
LEAD NITRATE | increased @ 25 ppm/3wks | accumulation in livers and kidneys versus controls | Male | Adult | 20/dose; 5/dose x time group | 0, 1, 5, 25 ppm diet | TOX-EXP IND - accumulation | 3, 6, 9, or 12 wks | diet | Toxicity Factor Datasets |
LEAD NITRATE | increased @ 5 ppm diet (66 +/-13 ppm blood) and @ 25 ppm diet (154 +/-28 ppm blood) | lead concentration in blood after 12 weeks exposure (mean +/- SE) versus controls | Male | Adult | 20/dose; 5/dose x time group | 0, 1, 5, 25 ppm diet | TOX-EXP IND - accumulation | 3, 6, 9, or 12 wks | diet | Toxicity Factor Datasets |
LEAD NITRATE | no effect | body weight and food consumption versus controls | Male | Adult | 20/group | 0, 1, 5, 25 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 3, 6, 9, or 12 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased in all groups dosed with lead shot | incidence of clinical signs, weight loss, breast muscle atrophy | Both Male and Female | Adult | treatment = 10/group control = 5 | 0, 4 #four lead shot; combined with commerical feed, Ca- supplemented corn diet, or corn only diet | TOX-Non-Repro-Sublethal - whole animal | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased with Pb/corn+Ca (50%), and Pb/corn only (100%) | % mortality versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 | 0, 4 #four lead shot; combined with commerical feed, Ca- supplemented corn diet, or corn only diet | TOX-MORT - dose-response data | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | decreased in Pb/commerical (hemoglobin only), Pb/corn+Ca, and Pb/corn only | red blood cell counts, packed cell volume, hemoglobin concentration versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 | 0, 4 #four lead shot; combined with commerical feed, Ca-supplemented corn diet, or corn only diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | intubation | Toxicity Factor Datasets |
LEAD (elemental) | increased with Pb/corn + Ca, Pb/corn only | blood protoporphyrin concentrations versus controls | Both Male and Female | Adult | treatment = 10/group control = 5 | 0, 4 #four lead shot; combined with commerical feed, Ca-supplemented corn diet, or corn only diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | intubation | Toxicity Factor Datasets |