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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | earlier @ 10 ppm | timing of peak progesterone concentration in blood | Female | Adult | 10-13/group | 0, or 10 ppm in diet | TOX-REPRO - physiology | 28 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased at 10, 40 ppm | length of courtship period | Both Male and Female | Adult | 8/group | 0, 10, 40 ppm in diet | TOX-REPRO - behavior | 42 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | decreased at 40 ppm | courtship behavior score (intensity) | Both Male and Female | Adult | 8/group | 0, 10, 40 ppm in diet | TOX-REPRO - behavior | 42 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | decreased at 10, 40 ppm | number of pairs nesting | Both Male and Female | Adult | 8/group | 0, 10, 40 ppm in diet | TOX-REPRO - behavior | 42 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | delayed at 10 ppm | onset of nest initiation | Both Male and Female | Adult | 8/group | 0, 10, 40 ppm in diet | TOX-REPRO - behavior | 42 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | metabolic rate at a range of ambient temperatures | Male | Adult | 4/group | 0 or 40 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 42 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | body weight | Male | Adult | 10/group | 0 or 40 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 42 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | decreased at 40 ppm | body temperature at a range of ambient temperatures | Male | Adult | 4/group | 0 or 40 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 42 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHIOCARB | decreased at 1,000 ppm | body weight | Not Reported | Not Reported | 6/group | 0, 100, 316, or 1,000 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30 d | diet | Toxicity Factor Datasets |
METHIOCARB | decreased at all doses | food consumption | Not Reported | Not Reported | 6/group | 0, 100, 316, or 1,000 ppm in diet | TOX-Non-Repro-Sublethal - behavioral effects | 30 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AMINOPYRIDINE (4-) | 150 ppm | dose at which 50% mortality was observed | Not Reported | Adult | 7/group | 150, 300, 600, 1,000 ppm 4-aminopyridine in corn bait | TOX-MORT - dose-response data | 7 d | diet | Toxicity Factor Datasets |
AMINOPYRIDINE (4-) | 316 ppm | dietary LC50 | Not Reported | Adult | 6/group | 0, 31.6, 100, 316 ppm 4-aminopyridine in diet | TOX-MORT - dose-response data | 30 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Units | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ALDICARB | 0.82 | LD50 | mg/kg bw | Not Reported | Adult | 50 birds total | 0.66, 0.74, 0.82, 0.90, 1.02, 1.10, 1.22, 1.40 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral | Toxicity Factor Datasets |
ALDICARB | no effect | daily survival rate in dosed wild birds | Not Reported | Adult | 9-12/group | 0, 0.48, 0.55, 0.83 mg/kg bw | TOX-MORT - mortality in the field | single | oral | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
PICLORAM, TRICLOPYR | no effect | nesting success in treated plots | Both Male and Female | Adult | Rob and Bessie Welder Wildlife Refuge | Not Reported | 38 l/ha application | TOX-Non-Repro-Sublethal - indirect effects | NR | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | no effect | Not Reported | Embryo | Patuxent Research Refuge | 2 eggs | 1 lb/gal DDT application to nest applied at 0.4 ml/ft^2 | TOX-REPRO - reproductive success | single | egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | significantly decreased compared to pre-1943 samples | eggshell thickness (of intact or broken eggshells) | Female | Adult | Anacapa Island and Isla Coronado Norte | 86 eggs | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | increased compared to positive control (1969 data) | mean number of fledglings produced per nest in 1974 | Both Male and Female | Fledgling | Anacapa Island and Isla Coronado Norte | 1286 nests | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | non-detectable DDT plus TDE, 96.6 ppm DDE, lipid wet basis | concentration in egg contents | Female | Adult | Anacapa Island and Isla Coronado Norte | 39 eggs | 0.03 ppm DDT plus TDE, 0.12 ppm DDE, wet wt in anchovies | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254, DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN | 0.896 ppm DDE, 0.256 ppm DDD, 0.166 ppm DDT, 0.208 dieldrin, 2.241 ppm PCB 1254 | mean residues in eggs | Female | Adult | east coast | 29 eggs | 0.017 ppm DDE, 0.016 ppm DDD, 0.020 ppm DDT, 0.005 ppm dieldrin, 0.196 ppm PCB 1254, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 8 ug/g | critical threshold of DDE concentration in egg (wet wt basis) associated with 20% eggshell thinning | Both Male and Female | Embryo | 813 eggs | ND-100 ug/g in eggs | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 3 ug/g | lowest level of DDE that would result in severely lowered reproductive success | Both Male and Female | Embryo | 156 eggs | ND-9 ug/g in eggs | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 3 ug/g | level in eggs associated with impaired reproductive success (successful nests fledged at least one chick) | Both Male and Female | Juvenile | 156 eggs | 0.36-8.60 ppm, wet wt in eggs | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
FUEL OILS | decrease | hatching success (proportion of eggs hatched per clutch) of oiled versus control eggs | Not Reported | Embryo | Cape Fear River | 61-205 eggs | oil spill | TOX-REPRO - reproductive success | NR | egg surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-) | decreased compared with pre-1940 eggs | eggshell thickness index (Ratcliffe's Index) | Not Reported | Embryo | Bear River Migratory Bird Refuge | 93 eggs | 6.6 ppm DDE, 1.3 ppm DDD in eggs, wet wt | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 12.8 ppm DDE, 0.8 ppm DDD, wet wt | mean concentration in breast muscle | Not Reported | Adult | Bear River Migratory Bird Refuge | 24 birds | 0.01-0.02 ppm DDE in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 61.5 ppm DDE, 5.2 ppm DDD, wet wt | mean concentration in visceral fat | Not Reported | Adult | Bear River Migratory Bird Refuge | 18 birds | 0.01-0.02 ppm DDE in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 0.55 ppm DDE, 0.07 ppm DDD, wet wt | mean concentration in blood | Not Reported | Adult | Bear River Migratory Bird Refuge | 16 birds | 0.01-0.02 ppm DDE in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 6.6 ppm DDE, 1.3 ppm DDD, wet wt | mean concentration in whole eggs | Not Reported | Embryo | 40 eggs | 0.01-0.02 ppm DDE in fish | TOX-EXP IND - accumulation | NR | diet (parental) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), POLYCHLORINATED BIPHENYLS | no effect | eggshell thickness compared with pre-1947 measurements | Not Reported | Embryo | Tule Lake National Wildlife Refuge | 29 eggs | 1.4 ppm DDE, 0.18 ppm DDT+DDD, 2.21 ppm PCBs in eggs | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
STRYCHNINE | increase at 6.7-44.5 mg/kg bw | Both Male and Female | Not Reported | 3-5/group | 0.01, 0.05, 0.5%; also reported as 1.4, 6.7, 44.5 mg/kg bw | TOX-MORT - dose-response data | 24 hr | drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | 3.77 mg/l (95% CI; 1.82 - 4.22) | LC50 | Not Reported | Tadpole | 10 tadpoles/replicate; 2 replicates/dose; 5 doses | 0.01-9.67 mg/l | TOX-MORT - toxicity benchmarks | 8 d | waterborne | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 1.78 mg/l | NOAEL | Not Reported | Tadpole | 10 tadpoles/replicate; 2 replicates/dose; 5 doses | 0.01-9.67 mg/l | TOX-MORT - toxicity benchmarks | 8 d | waterborne | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 9.67 mg/l | LOAEL | Not Reported | Tadpole | 10 tadpoles/replicate; 2 replicates/dose; 5 doses | 0.01-9.67 mg/l | TOX-MORT - toxicity benchmarks | 8 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | review | Not Reported | Not Reported | Not Reported | multiple | TOX-Non-Repro-Sublethal - whole animal | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FLUORIDE, SODIUM | 247.0 +/- 103.1 ppm @ 0 ppm; 6137.9 +/- 823.8 ppm @ 1120 ppm; 10,272.6 +/- 865.8 ppm @ 2240 ppm | mean fluoride content in the diaphyses of femurae | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-EXP IND - accumulation | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | no effect | growth of body weight and skeletal components (skull, bill, tarsus, antebrachium, and manus) | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | increased at 1120, 2240 ppm | % bone ash | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
FLUORIDE, SODIUM | decreased at 2240 ppm | bonebreaking strength | Both Male and Female | Juvenile | 9-10/group | 0, 1120, 2240 ppm fluoride | TOX-REPRO - development | 20 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) | increased with PCB 153 | aminopyrine N-demethylase and aldrin epoxidase activities in liver | Female | Adult | 5-6/group | 0, 4 mg/kg/d PCB 153, 3 mg/kg/d PCB 105, or 0.05 mg/kg/d PCB 126; 3 x's/wk | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wk | oral | Toxicity Factor Datasets |