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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased at 1606 ng/kg | hepatic EROD activity | Not Reported | Hatchling | Saskatchewan, British Columbia, Lake Ontario | 5-12 eggs/dose | 131, 250, 276, 672, 1606 ng/kg Toxic Equivalency Factors measured in eggs | TOX-EXP IND - biomarkers | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | positive regression | linear regression of hepatic EROD activity or cyt P450 content on Toxic Equivalency Factors | Not Reported | Hatchling | Saskatchewan, British Columbia, Lake Ontario | 5-12 eggs/dose | 131, 250, 276, 672, 1606 ng/kg Toxic Equivalency Factors measured in eggs | TOX-EXP IND - biomarkers | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | negative regression | linear regression of wing length on Toxic Equivalency Factors | Not Reported | Hatchling | Saskatchewan, British Columbia, Lake Ontario | 5-12 eggs/dose | 131, 250, 276, 672, 1606 ng/kg Toxic Equivalency Factors measured in eggs | TOX-REPRO - development | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | observed at 3, 10, 100 ug/kg | mortality | Not Reported | Hatchling | 6-10 eggs/dose | 0, 1, 3, 10, 100 ug/kg | TOX-REPRO - reproductive success | incubation day 22 to hatch | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | body and organ weights | Not Reported | Hatchling | 6-10 eggs/dose | 0, 1, 3, 10, 100 ug/kg | TOX-REPRO - development | incubation day 22 to hatch | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | observed at 3, 10, 100 ug/kg | edema | Not Reported | Hatchling | 6-10 eggs/dose | 0, 1, 3, 10, 100 ug/kg | TOX-REPRO - development | incubation day 22 to hatch | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased at 10, 100 ug/kg | hepatic microsomal cytP450 content | Not Reported | Hatchling | 6-10 eggs/dose | 0, 1, 3, 10, 100 ug/kg | TOX-EXP IND - biomarkers | incubation day 22 to hatch | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased at 3, 10, 100 ug/kg | hepatic microsomal EROD activity | Not Reported | Hatchling | 6-10 eggs/dose | 0, 1, 3, 10, 100 ug/kg | TOX-EXP IND - biomarkers | incubation day 22 to hatch | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 250 | Ratio of carcass concentration (4.6 ppm wet wt) to dietary concentration of PCBs | Not Reported | Adult | Lake Pointsett, Dry Lake | 10 carcasses | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 5.7 ppm wet wt PCBs | concentration in eggs | Female | Adult | Lake Pointsett, Dry Lake | 5 eggs | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 0.24 ppm wet wt PCBs | concentration in carcass | Not Reported | Juvenile | Lake Pointsett, Dry Lake | 5 birds | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 14 | Ratio of concentration in carcass (0.64 ppm wet wt mercury) to dietary concentration (fish) | Not Reported | Adult | Lake Pointsett, Dry Lake | 10 carcasses | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 0.29 ppm wet wt mercury | mean concentration in eggs | Female | Adult | Lake Pointsett, Dry Lake | 5 eggs | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 0.28 ppm wet wt mercury | concentration in liver | Not Reported | Nestling | Lake Pointsett, Dry Lake | 5 birds | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
MERCURY (elemental), POLYCHLORINATED BIPHENYLS | 7.98 ppm wet wt mercury | concentration in liver | Both Male and Female | Adult | Lake Pointsett, Dry Lake | 5 birds | <0.05-0.11 PCBs, <0.05-0.11 mercury, 0.016-0.092 OC insecticides; ppm (wet wt) in fish | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM (elemental), MERCURY (elemental) | no correlation | correlation of mean metallothionein concentration (13.2-24.4 ug/g tissue) and metal concentrations in kidneys | Not Reported | Both Adults and Juveniles | Heron Is., Manawagonish Is., Ile aux pommes | 24 birds | 0.03-6.3 ug Cd/g kidney, 0.77-12.9 ug Hg/g kidney, dry wt | TOX-EXP IND - biomarkers | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | positive correlation | correlation of embryo mortality with TCDD equivalents in eggs | Not Reported | Embryo | Great Lakes | 11 colonies @ 25-50 nests/colony | 35-344 pg TCDD eq/g wet wt | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), POLYCHLORINATED BIPHENYLS | 28.8% decrease | mean thickness of eggshells collected in 1969 compared with pre-1946 museum specimens | Female | Adult | Anacapa Island | 17 eggs | 754 ppm DDE, 87 ppm PCBs, 2.1 ppm DDD, 7.0 ppm DDT in egg yolk lipids | TOX-REPRO - physiology | NR | parent diet | Toxicity Factor Datasets |
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), POLYCHLORINATED BIPHENYLS | 38.3% decrease | mean thickness of eggshells collected in 1969 compared with pre-1946 museum specimens | Female | Adult | Los Coronados Island | 23 eggs | 574 ppm DDE, 422 ppm PCBs, 13.8 ppm DDD, 5.5 ppm DDT in egg yolk lipids | TOX-REPRO - physiology | NR | parent diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | increased at 400, 800 ug/kg egg | incidence of embryo mortality versus controls | Not Reported | Embryo | 15-60/group | 0,5,10,25,50,100,200,400,800 ug/kg egg | TOX-REPRO - reproductive success | incubation period | egg injection | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | increased at 5 ug/kg egg | weights of heart, liver and spleen versus controls | Not Reported | Hatchling | 8-29/group | 0,5,10,25,50,100,200,400,800 ug/kg egg | TOX-REPRO - development | incubation period | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | increased at 4.0 ug/kg egg | incidence of embryo mortality versus controls | Not Reported | Hatchling | 58-60/group | 0,0.06,0.25,1.0,4.0 ug/kg egg | TOX-REPRO - reproductive success | incubation period | egg injection | Toxicity Factor Datasets |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | no effect | weight of brain, heart, liver and spleen versus controls | Not Reported | Hatchling | Not Reported | 0,0.06,0.25,1.0,4.0 ug/kg egg | TOX-REPRO - development | incubation period | egg injection | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | decreased compared with reference | hatching success (# hatched/# eggs) | Both Male and Female | Hatchling | Spider Is., Lake Michigan | 466 and 953 nests (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | decreased compared with reference | clutch size | Female | Adult | Spider Is., Lake Michigan | 466 and 953 nests (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
POLYCHLORINATED BIPHENYLS | increased compared with reference | proportion of nestlings with bill defects | Both Male and Female | Hatchling | Spider Is., Lake Michigan | 1,511 and 2,700 chicks (2 yrs) | 7.34-8.22 ug/g egg (1.03 ug/g egg, reference site) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Range | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 31.3 | mean biomagnification factor for eggs from forage fish | 11.7-56.8 | Female | Adult | 12 eggs/site x 5 sites | 5.8-24.4 pgTCDD equivalents/g fish, wet wt, (5 sites) | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 162.4 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | Green Bay, Lake Michigan | 20 chicks | 24.4 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 100.4 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained from egg to largest chick stage | Not Reported | Nestling | Beaver Islands, Lake Michigan | 20 chicks | 5.8 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 37.6 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | Thunder Bay, Lake Huron | 20 chicks | 18.1 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 28.3 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | North Channel, Lake Huron | 20 chicks | 7.6 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets | |
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) | 47.5 pg/g bw gained (wet wt) | pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) | Not Reported | Nestling | St. Martin's Shoal, Lake Huron | 20 chicks | 11.1 pg TCDD equivalents/g fish, wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CHLORDANE | 8,906 ppb, range; 4,954 - 15, 609 ppb | mean and range of total technical chlordane residues in newt carcasses (without liver and stomach) 14 days after application | Both Male and Female | Both Adults and Juveniles | 4 | aerial application; water residues, 4.6 ppb (day 7), 0.29 ppb (day 52), 0.009 ppb (day 421); sediment residues, 35 ppb (day 7), 34 ppb (day 52), 20 ppb (day 1014) | TOX-EXP IND - accumulation | 14 d | field application | Toxicity Factor Datasets |
CHLORDANE | 2,116 ppb, range; 1,354 - 3,783 ppb | mean and range of total technical chlordane residues in newt carcasses (without liver and stomach) 451 days after application | Both Male and Female | Both Adults and Juveniles | 6 | aerial application; water residues, 4.6 ppb (day 7), 0.29 ppb (day 52), 0.009 ppb (day 421); sediment residues, 35 ppb (day 7), 34 ppb (day 52), 20 ppb (day 1014) | TOX-EXP IND - accumulation | 451 d | field application | Toxicity Factor Datasets |
CHLORDANE | 176 ppb, range; 29 - 272 ppb | mean and range of total technical chlordane residues in newt carcasses (without liver and stomach) 1036 days after application | Both Male and Female | Both Adults and Juveniles | 8 | aerial application; water residues, 4.6 ppb (day 7), 0.29 ppb (day 52), 0.009 ppb (day 421); sediment residues, 35 ppb (day 7), 34 ppb (day 52), 20 ppb (day 1014) | TOX-EXP IND - accumulation | 1036 d | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | no effect | discrimination between seeds and beads | Both Male and Female | Adult | 22 animals | control, 5 mg/kg bw | TOX-Non-Repro-Sublethal - behavioral effects | single dose | gavage | Toxicity Factor Datasets |
METHYLPARATHION | 18-19 % decrease | brain cholinesterase activity, compared to control | Both Male and Female | Adult | 2 animals | control, 5 mg/kg bw | TOX-EXP IND - biomarkers | single dose | gavage | Toxicity Factor Datasets |
METHYLPARATHION | 97.1 mg/kg (95% CI, 42.6-178.6 mg/kg) | LD50 | Both Male and Female | Adult | 3-4 animals/group | 0,35,56,90,143 mg/kg | TOX-MORT - dose-response data | single dose | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CARBARYL | increased at 0.56 kg/ha (2, 8-9 d. post-spray) | whole carcass concentration of carbaryl | Not Reported | Not Reported | 8-9 birds/group | 0, 0.44, 0.56 kg/ha application | TOX-EXP IND - accumulation | 2, 8-9, 21-30 d. post-spray | field application | Toxicity Factor Datasets |
CARBARYL | no effect | whole carcass lipid content | Not Reported | Not Reported | 6-13 birds/group | 0, 0.44, 0.56 kg/ha application | TOX-Non-Repro-Sublethal - whole animal | 2, 8-9, 21-30 d. post-spray | field application | Toxicity Factor Datasets |