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Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
SULFURIC ACID | significant increase at pH 3.5 and 4.0 | Not Reported | Tadpole | 120 animals/dose | pH = 3.5, 4.0, 4.5, 5.0, 6.3 | TOX-MORT - dose-response data | 3 wk | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
PARATHION | no effect | Not Reported | Tadpole | 30 animals/dose | 0, 1 mg/l (nominal) | TOX-MORT - dose-response data | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 99 ug/l (95% CL: 71-116 ug/l) | LC50 | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
ENDRIN | 2 ug/l (95% CL: 1-5 ug/l) | LC50 | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 312 ug/l (95% CL: 225-435 ug/l) | EC50; Loss of equilibrium | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-REPRO - behavior | 96 hr | waterborne | Toxicity Factor Datasets |
ENDRIN | > 40 ug/l | EC50; Loss of equilibrium | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-REPRO - behavior | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PERMETHRIN | 7,033 ug/l (95% CL: 4,129-8,735 ug/l) | LC50 | Not Reported | Tadpole | 10 animals/replicate; 4 replicates/dose | NR | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CHLORDANE | no effect | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
CHLORDANE | increase at 0.5 lb/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
ENDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
DIELDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
ALDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | increase at 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
LINDANE | increase at 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ARSENIC COMPOUNDS, BARIUM COMPOUNDS, CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, SELENIUM COMPOUNDS | increase | incidence of oral deformities at coal ash contaminated site, relative to reference site | Not Reported | Tadpole | Savannah River, Aiken | 575-1048 | mean whole body concn. at contaminated (C) compared to reference (R) site: As, C=48.9 +/- 2.6SE, R=2.5 +/-0.2SE; Ba, C=211.5 +/- 14.9SE, R=81.2 +/- 5.2SE; Cd, C=1.71 +/- 0.5SE, R=0.15 +/- 0.04SE; Cr, C=17.2 +/- 0.5SE, R=1.4 +/- 0.3SE; Cu, C=31.4 +/- 1.5SE | TOX-REPRO - development | NR | site contamination | Toxicity Factor Datasets |
ARSENIC COMPOUNDS, BARIUM COMPOUNDS, CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, SELENIUM COMPOUNDS | increase at contaminated (C) compared to reference (R) site: Arsenic, C=48.9 +/- 2.6SE, R=2.5 +/-0.2SE; Barium, C=211.5 +/- 14.9SE, R=81.2 +/- 5.2SE; Cadmium, C=1.71 +/- 0.5SE, R=0.15 +/- 0.04SE; Chromium, C=17.2 +/- 0.5SE, R=1.4 +/- 0.3SE; Copper, C=31.4 +/- 1.5SE, R=17.5 +/- 6.6SE; Selenium, C=25.70 +/- 3.60SE, R=3.37 +/- 0.09SE. | mean whole body metal concentrations (ppm, dry mass) | Not Reported | Tadpole | Savannah River, Aiken | 3 animals/site | sediment concn. at contaminated (C) compared to reference (R) site: As, C=70.8 +/- 12.5SE, R=<1.0; Ba, C=418.7 +/- 34.0SE, R=11.8 +/- 0.6SE; Cd, C=0.57 +/- 0.05SE, R=0.03 +/- 0.00SE; Cr, C=70.8 +/- 12.5SE, R=<1.0; Cu, C=71.8 +/- 12.3SE, R=<1.0; Se, C=6.21 | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | 34.4 ug/l (95% CL: 31.1 - 38.1 ug/l) | LC50 | Not Reported | Embryo | 20 animals/replicate; 4 replicates/dose | 0, 0.8, 2.0, 4.9, 11.0, 25.4, 64.8, 154.8 ug/l | TOX-MORT - toxicity benchmarks | 21 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARATHION | 25% at 4.6 ppm | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-MORT - dose-response data | up to 24 hr | diet | Toxicity Factor Datasets | |
PARATHION | 47% decrease at 4.6 ppm | mean brain cholinesterase activity relative to control | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | up to 24 hr | diet | Toxicity Factor Datasets |
PARATHION | 56% decrease at 4.6 ppm | mean plasma cholinesterase activity relative to control | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-EXP IND - biomarkers | up to 24 hr | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 31% decrease at 625 mg/kg bw 14% decrease at 125 mg/kg bw | hematocrit | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | 48% decrease at 625 mg/kg bw 27% decrease at 125 mg/kg bw 12% decrease at 25 mg/kg bw | red blood cell hemoglobin content | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at all doses (45-59%) | red blood cell delta aminolevulinic acid dehydratase | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | 30% decrease at 625 mg/kg bw 25% decrease at 125 mg/kg bw | plasma creatine phosphokinase | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (47-57%) | brain delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (71-79%) | kidney delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (20-25%) | liver delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 40% at 625 mg/kg bw | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-MORT - dose-response data | 10 d | gavage | Toxicity Factor Datasets | |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | body weight at end of dosing relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | growth rate relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at all doses 1.4, 3.5, 5.5 ppm at 25, 125, 625 mg/kg bw, respectively | liver lead concentration | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at 125, 625 mg/kg bw 7.2, 15.5 ppm at 125, 625 mg/kg bw, respectively | kidney lead concentrations | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decrease at 10, 50 ppm | mean blood delta aminolevulinic acid dehydratase | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-EXP IND - biomarkers | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean packed cell volume and red blood cell hemoglobin | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | increase at 50 ppm 1.3 ppm (1.00 SD) males; 2.4 ppm (1.40 SD) females | mean lead concentration in liver | Both Male and Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean organ and carcass weights | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 1.13 ppm blood at 212 ppm; 1.69 ppm blood at 448 ppm | mean lead concentration in blood | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 7.84 ppm femur at 120 ppm; 16.60 ppm femur at 212 ppm; 18.44 ppm femur at 448 ppm | mean lead concentration in femur | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | no effect | packed cell volume, hemoglogin concentration, erythrocyte counts | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIMETHYLMERCURY | no effect | eggshell thickness | Female | Adult | Not Reported | 0, 10 ppm | TOX-REPRO - physiology | 3 mo | diet | Toxicity Factor Datasets |