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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | thyroid hormone concentrations versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 42 days | Diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | adrenal wt, corticosterone concentrations versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-Non-Repro-Sublethal - organ/system effects | 42 days | Diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 10, 50 ug/g diet | liver cadmium concentration versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | liver Cu concentration versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | liver Zn concentration versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 10, 50 ug/g diet | kidney Cd concentration versus controls | Male | Adult | 8 | 0, 10, or 50 ug Cd/g | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 20.4% decrease | eggshell thickness versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-REPRO - physiology | 3 weeks | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | 17% decrease | serum calcium versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3 weeks | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | serum calcium after PTH injection versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3 weeks | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD ACETATE | decreased | % packed cell volume versus controls | Male | Adult | 10 | 20 ppm x 1.6(week, after 1st week) | TOX-Non-Repro-Sublethal - organ/system effects | 15 weeks | Diet | Toxicity Factor Datasets |
LEAD ACETATE | decreased | hemoglobin concentration versus controls | Male | Adult | 10 | 20 ppm x 1.6(week, after 1st week) | TOX-Non-Repro-Sublethal - organ/system effects | 15 weeks | Diet | Toxicity Factor Datasets |
LEAD ACETATE | increased | protoporphyrin concentration versus controls | Male | Adult | 10 | 20 ppm x 1.6(week, after 1st week) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 15 weeks | Diet | Toxicity Factor Datasets |
LEAD ACETATE | decreased | ALAD enzyme activity versus controls | Male | Adult | 10 | 20 ppm x 1.6(week, after 1st week) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 15 weeks | Diet | Toxicity Factor Datasets |
LEAD ACETATE | increased | iron concentration in liver versus controls | Male | Adult | 10 (controls); 30 (treated) | 20 ppm x 1.6(week, after 1st week) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 15 weeks | Diet | Toxicity Factor Datasets |
LEAD ACETATE | increased | liver and kidney Pb concentrations versus controls | Male | Adult | 30 | 20 ppm x 1.6(week, after 1st week) | TOX-EXP IND - accumulation | 15 weeks | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | one shot: 180.4 (18.1), female; 5.0 (0.6), male two shot: 183.4 (21.2), female; 15.9 (4.1), male | mean (SE) lead residues in femur | Both Male and Female | Adult | 20 females, 10 males/group | 0, 1, 2 lead shot (206 mg avg wt) | TOX-EXP IND - accumulation | Single dose (one shot); repeated dose (two shot) | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 40, 80 ppm selenite or selenomethionine | duckling mortality versus controls | Not Reported | Juvenile | 40 birds/group | 0, 10, 20, 40, or 80 ppm Se as selenomethionine or sodium selenite | TOX-Non-Repro-Sublethal - whole animal | 6 weeks | Diet | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | decreased | food consumption versus controls | Not Reported | Juvenile | 40 birds/group | 0, 10, 20, 40, or 80 ppm Se as selenomethionine or sodium selenite | TOX-Non-Repro-Sublethal - whole animal | 6 weeks | Diet | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | decreased (liver decreased with selenite only) | bw and liver wt versus controls | Not Reported | Juvenile | 40 birds/group | 0, 10, 20, 40, or 80 ppm Se as selenomethionine or sodium selenite | TOX-Non-Repro-Sublethal - whole animal | 6 weeks | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIAZINON | decreased (84%) | percent inhibition of post-mortem brain cholinesterase activity compared to control | Not Reported | Juvenile | 5 ducks | 183 ug/g ingesta | TOX-EXP IND - biomarkers | NR | diet | Toxicity Factor Datasets |
BENDIOCARB | decreased (73%) | percent inhibition of post-mortem brain cholinesterase activity compared to control | Not Reported | Adult | 4 ducks | 1.17 ug/g ingesta | TOX-EXP IND - biomarkers | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LINDANE | 18-21% decrease @ 20 mg/kg 7x or 3x/wk | eggshell thickness, compared to control | Female | Adult | 5/dose | control, 20 mg/kg given 7x, 3x or 2x/wk | TOX-REPRO - physiology | 8 wks | gavage | Toxicity Factor Datasets |
LINDANE | decrease @ 20 mg/kg 7x or 3x/wk | calcium concentration in plasma and shell gland mucosa and density and size of eggshell pores | Female | Adult | 5/dose | control, 20 mg/kg given 7x, 3x or 2x/wk | TOX-REPRO - physiology | 8 wks | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
DDT (Technical Grade Mixture) | increase @ 0.05 - 0.4% in diet | Not Reported | Not Reported | 4/dose | 0, 0.025, 0.05, 0.1, 0.2, 0.4% | TOX-MORT - dose-response data | 30 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDT (Technical Grade Mixture) | no effect | fertility, hatchability and duckling weight | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-REPRO - reproductive success | 343 d | diet | Toxicity Factor Datasets |
DDT (4,4'-) | no effect | fertility, hatchability and duckling weight | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-REPRO - reproductive success | 343 d | diet | Toxicity Factor Datasets |
DIELDRIN | no effect | fertility, hatchability and duckling weight | Female | Adult | 18/dose | 0, 1, 5, 10 mg/kg diet | TOX-REPRO - reproductive success | 343 d | diet | Toxicity Factor Datasets |
DDT (Technical Grade Mixture) | no effect | hepatic microsomal enzyme activity (aniline hydroxylase and aminopyrine N-demethylase) | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 343 d | diet | Toxicity Factor Datasets |
DDT (4,4'-) | no effect | hepatic microsomal enzyme activity (aniline hydroxylase and aminopyrine N-demethylase) | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 343 d | diet | Toxicity Factor Datasets |
DIELDRIN | no effect | hepatic microsomal enzyme activity (aniline hydroxylase and aminopyrine N-demethylase) | Female | Adult | 18/dose | 0, 1, 5, 10 mg/kg diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 343 d | diet | Toxicity Factor Datasets |
DDT (Technical Grade Mixture) | DDT <0.1, DDE 0.2 - 1.2 ug/g dry wt @ 0 ppm; DDT 0.3 - 4.2, DDE 1.0 - 12.7 @ 2 ppm; DDT 1.3 - 25.0, DDE 5.0 - 110.1 @ 20 ppm; DDT 25.5 - 254, DDE 58.0 - 1234 @ 200 ppm | DDT and DDE concentrations in egg dry matter ranging from 0-14 d to 330 - 343 d sampling periods at 4 dietary doses | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-EXP IND - accumulation | 343 d | diet | Toxicity Factor Datasets |
DDT (4,4'-) | DDT <0.1, DDE 0.2 - 1.2 ug/g dry wt @ 0 ppm; DDT 0.6 - 2.4, DDE 1.2 - 10.1 @ 2 ppm; DDT 2.2 - 29.2, DDE 15.7 - 153.5 @ 20 ppm; DDT 14.9 - 102.0, DDE 45.0 - 187.0 @ 200 ppm | DDT and DDE concentrations in egg dry matter ranging from 0-14 d to 330 - 343 d sampling periods at 4 dietary doses | Female | Adult | 18/dose | 0, 2, 20, 200 mg/kg diet | TOX-EXP IND - accumulation | 343 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TRIETHYLTIN CHLORIDE | decrease @ 50 ppm | body weight, compared to control | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as triethyltin chloride | TOX-Non-Repro-Sublethal - whole animal | 73 - 75 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | egg production, eggshell thickness and fertility, compared to control | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | control, 4 ppm | TOX-REPRO - physiology | 90 d | diet | Toxicity Factor Datasets |
DIELDRIN | decrease | average % hatchability, compared to controls | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | control, 4 ppm | TOX-REPRO - reproductive success | 90 d | diet | Toxicity Factor Datasets |
DIELDRIN | no effect | progeny growth (average body weights) at hatch to 6 wks of age | Both Male and Female | Juvenile | 5 trios (2F, 1M adults)/dose | control, 4 ppm | TOX-REPRO - development | 90 d | diet | Toxicity Factor Datasets |
PARATHION | no effect | egg production and fertility, compared to controls | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | control, 10 ppm | TOX-REPRO - physiology | 90 d | diet | Toxicity Factor Datasets |
PARATHION | no effect | % hatchability, compared to controls | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | control, 10 ppm | TOX-REPRO - reproductive success | 90 d | diet | Toxicity Factor Datasets |
PARATHION | decrease | eggshell thickness, compared to controls | Both Male and Female | Adult | 5 trios (2F, 1M)/dose | control, 10 ppm | TOX-REPRO - physiology | 90 d | diet | Toxicity Factor Datasets |
PARATHION | no effect | progeny growth (average body weights) at hatch to 6 wks of age | Both Male and Female | Juvenile | 5 trios (2F, 1M adults)/dose | control, 10 ppm | TOX-REPRO - development | 90 d | diet | Toxicity Factor Datasets |