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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID | Egg; 3 ug/g @ 30 ppm, 13 ug/g @ 300 ppm, 49 ug/g @ 1000 ppm: Liver; 15 ug/g @ 300 ppm, 33 ug/g @ 1000 ppm: Brain; 14 ug/g @ 300 ppm, 41 ug/g @ 1000 ppm | boron concentrations in adult tissues (geometric mean; ug/g dry weight). | Both Male and Female | Adult | 10-20/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-EXP IND - accumulation | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | Liver; 3 ug/g @ 30 ppm, 17 ug/g @ 300 ppm, 51 ug/g @ 1000 ppm: Brain; 4 ug/g @ 30 ppm, 19 ug/g @ 300 ppm, 66 ug/g @ 1000 ppm | boron concentrations in ducklings 21 d of age (geometric mean; ug/g dry weight). Concentrations at other doses were not detected. | Both Male and Female | Juvenile | 10-13/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-EXP IND - accumulation | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | % mortality, compared to controls | Male | Adult | 5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg South Louisiana crude oil, daily | TOX-MORT - dose-response data | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | no effect | body weight, gross lesions or signs of clinical illness, compared to controls | Male | Adult | 5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg South Louisiana crude oil, daily | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | no effect | body weight and gross lesion incidence, compared to controls | Male | Adult | 4-5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | decrease @ 4.0, 7.0, 12.0 ml/kg/d | mean spleen index (spleen wt./body wt.) | Male | Adult | 4-5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
COREXIT 9527 | no effect | % mortality, compared to controls | Male | Adult | 6/dose | control, 0.006, 0.012, 0.025, 0.05 ml/kg, daily; diluted in water | TOX-MORT - dose-response data | 28 d | gavage | Toxicity Factor Datasets |
COREXIT 9527 | no effect | body weight, compared to controls | Male | Adult | 6/dose | control, 0.006, 0.012, 0.025, 0.05 ml/kg, daily; diluted in water | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | increase @ 2.5, 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 9-32/dose | control, 2.5, 4.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | increase @ 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 10-32/dose | control, 2.5, 4.0 ml/kg South Louisiana crude oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS, FUEL OILS | no effect | antibody-mediated immunity estimated by direct spleen plaque-forming cell assays (PFCs/g spleen); mallards inoculated with sheep red blood cells on day 24 | Male | Adult | 9/dose | control, 4.0 ml/kg South Louisiana crude oil or Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | body weight | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - whole animal | 9 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increase | plasma triglyceride and sodium concentrations, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease | hematocrit and plasma cholesterol concentration, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
COREXIT 9527 | no effect | body weight | Not Reported | Juvenile | 25/dose | control, 0.015% | TOX-Non-Repro-Sublethal - whole animal | 9 wks | diet | Toxicity Factor Datasets |
COREXIT 9527 | increase | plasma alanine aminotransferase activity, compared to control | Not Reported | Juvenile | 25/dose | control, 0.015% | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FUEL OILS | decrease @ 5, 10, 20, 50 ul | 6-day % survival of mallard embryos from eggs treated on the 8th day of incubation | Not Reported | Embryo | 50/dose | control, 5, 10, 20, 50 ul Bunker C fuel oil, applied externally to the air cell of viable eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
FUEL OILS | decrease @ 5, 10, 20, 50 ul | 30-d % hatching success | Not Reported | Embryo | 50/dose | control, 5, 10, 20, 50 ul Bunker C fuel oil, applied externally to the air cell of viable eggs | TOX-REPRO - reproductive success | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 1, 5, 10 ul | 18-d % survival, mean embryonic weight, crown-rump length (5ul) and bill length | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
CRUDE OILS | increase @ 1, 5 ul | % abnormal survivors, compared to controls | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | onset of laying, egg production, egg fertility, compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - physiology | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease | egg hatchability (# eggs hatching/# fertile eggs), compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - reproductive success | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | onset of laying, egg production, egg fertility and egg hatchability, compared to controls | Female | Adult | 20 hens/dose | control, 5 ppm | TOX-REPRO - physiology | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
POLYCYCLIC AROMATIC HYDROCARBONS (PAHs) | increase @ 0.2, 2.0 mg/kg egg | embryonic mortality, compared to controls | Not Reported | Embryo | 22/dose | control, 0.2, 2.0 mg/kg egg, mixture of 18 PAHs; injected into egg yolks | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
BENZO[k]FLUORANTHENE | increase @ 0.2, 2.0 mg/kg egg | embryo mortality, compared to controls | Not Reported | Embryo | 20/dose | control, 0.2, 2.0 mg benzo[k]fluoranthene/kg egg; injected into egg yolks | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | decrease @ 0.5% | body weight, average daily weight gain and tibiotarsus length, compared to controls | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-Non-Repro-Sublethal - whole animal | 15 d | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | 3.59 ppm dry wt @ control, 5.16 ppm @ 0.1%, 15.52 ppm @ 0.05% | liver aluminum concentrations (ppm, dry wt) in ducklings | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-EXP IND - accumulation | 15 d | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | no effect | plasma growth hormone and insulin-like growth factor-I concentrations | Not Reported | Juvenile | 8/dose | control, 0.1, 0.5% aluminum as Al2(SO4)3 | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 15 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SEWAGE SLUDGE | no effect | immune defenses; resistance to Pasturella multocida estimated by % mortality 14 d after challenge, compared to controls | Male | Adult | 10/dose | control, 5%, 20% Milorganite or Metrogro | TOX-Non-Repro-Sublethal - organ/system effects | 28 d (Milorganite); 57 d (Metrogro) | diet | Toxicity Factor Datasets |
SEWAGE SLUDGE | increase @ 20% Milorganite or Metrogro | liver cadmium concentrations; compared to controls | Male | Adult | 10/dose | control, 5%, 20% Milorganite or Metrogro | TOX-EXP IND - accumulation | 28 d (Milorganite); 57 d (Metrogro) | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TRIMETHYLTIN CHLORIDE | increase @ 5, 50 ppm | % mortality (100% mortality within 5 d for 50 ppm dose), compared to controls | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-MORT - dose-response data | 73 - 75 d | diet | Toxicity Factor Datasets |
TRIMETHYLTIN CHLORIDE | increase @ 50 ppm | incidence of mild to marked degeneration of neurons of the pons, medulla oblongata, gray matter of the spinal cord and pyrimidal cells of the cerebral cortex; mild to moderate lympoid depletion of spleen and thymus; atrophy of myofibers in skeletal and ca | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 73-75 d | diet | Toxicity Factor Datasets |
TRIMETHYLTIN CHLORIDE | 17% decrease @ 5 ppm | body weight | Not Reported | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - whole animal | 73 - 75 d | diet | Toxicity Factor Datasets | |
TRIMETHYLTIN CHLORIDE | increase @ 5 ppm | cephalic tumor incidence | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as trimethyltin chloride | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 73 - 75 d | diet | Toxicity Factor Datasets |
TRIETHYLTIN CHLORIDE | no effect | % mortality, compared to controls | Not Reported | Juvenile | 5/dose | control, 0.5, 5.0, 50 ppm (Sn) as triethyltin chloride | TOX-MORT - dose-response data | 73 - 75 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PHOSPHORUS (YELLOW OR WHITE) | 6.96 mg/kg bw (2.66-8.96 95% CI) | 24 hour median lethal dose | Female | Adult | 6 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 6.46 mg/kg bw (5.19-7.69 95% CI) | 24 hour median lethal dose | Male | Adult | 4-5 birds/dose | 0, 2, 4, 5.2, 6.1, 7.1, 8.0, 9.1 mg/kg bw (dissolved in corn oil) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | 3.90 mg/kg bw (3.24-4.69 95% CI) | 24 hour median lethal dose | Female | Adult | 4-5 birds/dose | 0, 1.0, 2.0, 3.4, 4.0, 6.5 mg/kg bw (pelletized) | TOX-MORT - toxicity benchmarks | single | oral gavage | Toxicity Factor Datasets |
PHOSPHORUS (YELLOW OR WHITE) | reduced above 6.2 mg/kg bw | body weight versus controls | Not Reported | Adult | 4-5 birds/dose | 0, 6.0, 7.9, 10.2, 13.5, 18.0 mg/kg bw (dissolved in corn oil) | TOX-Non-Repro-Sublethal - whole animal | single | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
POLYCHLORINATED BIPHENYLS | review | incidence of reproductive effects | Both Adults and Juveniles, Embryo | Not Reported | NR | TOX-REPRO - reproductive success | NR | NR | Toxicity Factor Datasets |