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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PENTACHLOROPHENOL | 12.2 +/- 2.3 ug/g lipid, 20.7 +/- 3.7 ug/g liver, 3.3 +/- 1.6 ug/g muscle, 2.6 +/- 1.5 ug/g brain at 423.2 ug/g diet | mean +/- SD tissue concentrations at the reported NOAEL (development) | Not Reported | Juvenile | 6-8 | 25.0, 54.2, 105.0, 233.2, 423.2, 961.0 ug/g diet | TOX-EXP IND - accumulation | 11 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | no effect | total body weight, compared to control | Not Reported | Juvenile | 4-6/dose | <0.2, 2.6, 26.2, 49.3 ug/g diet | TOX-REPRO - development | 8 d | diet | Toxicity Factor Datasets |
DIELDRIN | 9.7 ug/g lipid, 3.3 ug/g skin, 1.3 ug/g brain, 0.8 ug/g liver, 0.7 ug/g muscle at 2.6 ug/g food | mean of day 5, 7, 8 (approx. steady state) tissue concentrations | Not Reported | Juvenile | 6 | <0.2, 2.6, 26.2, 49.3 ug/g diet | TOX-EXP IND - accumulation | 8 d | diet | Toxicity Factor Datasets |
DIELDRIN | 42.5 ug/g lipid, 14.6 ug/g skin, 1.6 ug/g brain, 2.5 ug/g liver, 1.2 ug/g muscle at 26.2 ug/g food | mean of day 5, 7, 8 (approx. steady state) tissue concentrations | Not Reported | Juvenile | 6 | <0.2, 2.6, 26.2, 49.3 ug/g diet | TOX-EXP IND - accumulation | 8 d | diet | Toxicity Factor Datasets |
DIELDRIN | 80.7 ug/g lipid, 30.1 ug/g skin, 1.6 ug/g brain, 4.1 ug/g liver, 1.8 ug/g muscle at 49.3 ug/g food | mean of day 5, 7, 8 (approx. steady state) tissue concentrations | Not Reported | Juvenile | 6 | <0.2, 2.6, 26.2, 49.3 ug/g diet | TOX-EXP IND - accumulation | 8 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | 0.51-0.54 ppm blood, 2.07-2.41 ppm kidney, 2.35-2.26 ppm liver, 0.74-0.97 ppm breast muscle, 0.47-0.51 ppm brain, 0.88 ppm eggs @ 0.5 ppm in diet | range of mean Hg (ppm wet-weight) concentrations in wild-strain males and females | Both Male and Female | Adult | 6-9 (9 breeding pairs/dose) | control and 0.5 mg Hg/kg diet (Hg as methylmercury dicyandiamide) | TOX-EXP IND - accumulation | 22 Dec. to 27 July, 1976; approx. 7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 10.6 +/- 2.2 ppm nasal gland, 16.1 +/- 5.1 ppm liver, 5.8 +/- 1.1 ppm kidney, 1.9 +/- 0.1 ppm brain @ 100 ppm diet | mean (+/- SE) DDE levels (ppm wet weight) | Both Male and Female | Juvenile | 4 | control or 100 ppm DDE | TOX-EXP IND - accumulation | 7 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | nasal gland secretion volume | Both Male and Female | Juvenile | 5-11 | control, 10, 50 ppm DDE | TOX-Non-Repro-Sublethal - organ/system effects | 7 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | nasal gland and kidney Na-K-ATPase activity, following exposure to 100% seawater | Both Male and Female | Juvenile | 4-5 | control or 100 ppm DDE | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 7 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | body weight or plasma electrolyte levels | Both Male and Female | Juvenile | 4 | control, 10-100 ppm DDE | TOX-Non-Repro-Sublethal - whole animal | 7 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 1.23 +/- 0.12 ug/g wet weight | mean +/- SE p,p'-DDE concentration in shell gland mucosa | Female | Adult | Not Reported | control, 40 mg/kg dry weight diet | TOX-EXP IND - accumulation | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 28% decrease @ 40 mg/kg | eggshell index (shell weight/shell length x breadth), compared to control | Female | Adult | 9-20/group | control, 40 mg/kg dry weight diet | TOX-REPRO - physiology | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | plasma calcium concentration | Female | Adult | Not Reported | control, 40 mg/kg dry weight diet | TOX-Non-Repro-Sublethal - organ/system effects | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 25% decrease @ 40 mg/kg | calcium content of secreted fluid in the shell gland, compared to control | Female | Adult | 5/dose | control, 40 mg/kg dry weight diet | TOX-REPRO - physiology | 45 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 18% decrease @ 40 mg/kg | eggshell index (shell weight/length x breadth), compared to control | Female | Adult | 18 | control, 40 mg/kg dry weight | TOX-REPRO - physiology | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 38 ug/g wet weight egg (yolk + white), 1.20 ug/g wet weight egg shell gland mucosa @ 40 mg/kg | mean DDE concentrations | Female | Adult | 7-9 | control, 40 mg/kg dry weight | TOX-EXP IND - accumulation | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 32% decrease @ 40 mg/kg | Ca2+-Mg2+ ATPase activity in eggshell gland mucosa homogenates, compared to controls | Female | Adult | Not Reported | control, 40 mg/kg dry weight | TOX-REPRO - physiology | 45 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 44% increase @ 40 mg/kg | calcium content (umol/g dry weight) of eggshell gland mucosa, compared to controls | Female | Adult | Not Reported | control, 40 mg/kg dry weight | TOX-REPRO - physiology | 45 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
STRYCHNINE | increase | strychnine poisoning via grain bait diagnosed as cause of death in free-flying mallards | Both Male and Female | Adult | Saskatoon, Saskatchewan | 4 | 19.7 - 85.1 mg strychnine/kg ingesta | TOX-MORT - mortality in the field | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | body weight; body and skin temperature at 16C; mean heat production and thermal conductance at 16C | Not Reported | Adult | 5/dose | control, 5 ml/kg bird/d Statfjord A crude oil | TOX-Non-Repro-Sublethal - whole animal | 6 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | increase | body temperature at an ambient temperature of -17C, compared to control | Not Reported | Adult | 5/dose | control, 5 ml/kg bird/d Statfjord A crude oil | TOX-Non-Repro-Sublethal - whole animal | 6 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase @ 1% and 3% | hepatic microsomal naphthalene metabolism (nmol/min/mg protein), compared to control, in adult females and in neonatal ducklings hatched from eggs laid by females (1% Prudhoe Bay dose level was not significantly different for neonates). | Female | Adult | 6 adults/dose; 5-20 neonates/dose | control, 1%, 3% (ml oil/100 g dry wt food); South Louisiana and Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 3% | plasma corticosterone concentration, compared to control | Male | Juvenile | 24/dose | control, 3% (3 ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1 wk | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 3% | body weight | Male | Juvenile | Not Reported | control, 0.5, 1, 3% ( ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - whole animal | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 1 and 3% | daily food intake rate | Male | Juvenile | Not Reported | control, 0.5, 1, 3% ( ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - whole animal | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 0.5, 1, 3% | plasma corticosterone concentration, compared to control | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3-9 d | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 0.5% | plasma corticosterone concentration, compared to control | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 0.5, 1, 3% | hepatic microsomal naphthalene metabolism (nmol/min/mg protein) | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 50 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID | decrease @ 1600 ppm | growth rate measured as changes in body weight, compared to control | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 1600 ppm | hematocrit and hemoglobin concentration, compared to controls | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 100, 400, 1600 ppm | plasma triglyceride concentration (21-42% increase, compared to controls) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 1600 ppm | plasma calcium concentration (6-10% greater than controls) and brain acetylcholinestrase activity (umol/min/g) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | 2 ug/g @ control; 4 ug/g @ 100 ppm; 5 ug/g @ 400 ppm; 51 ug/g @ 1600 ppm | boron accumulation in brain (geometric mean; ug/g dry weight) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 400 and 1600 ppm | brain ATP (nmol/g) and protein (mg/g) concentrations | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | 1 ug/g @ controls; 3 ug/g @ 100 ppm; 3 ug/g @ 400 ppm; 29 ug/g @ 1600 ppm | liver boron concentration (geometric mean; ug/g dry weight) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID | decrease @ 1000 ppm | % hatching success in fertile eggs and productivity per female (mean # of 21 d old ducklings) | Both Male and Female | Adult | 15/sex/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - reproductive success | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | no effect | eggshell thickness and Ratcliffe index of eggshell quality | Female | Adult | 15/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - physiology | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 1000 ppm | % embryo mortality (day 15 to hatch) and duckling mortality (hatch to day 7) | Both Male and Female | Both Adults and Juveniles | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - development | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 300, 1000 ppm | body weight of hatchlings, compared to controls | Both Male and Female | Hatchling | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - development | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 30, 300, 1000 ppm | hatchling weight gain over 21 d, compared to controls | Both Male and Female | Hatchling | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-Non-Repro-Sublethal - whole animal | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |