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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | no effect | bill length | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ 1200 pmm (30 d of age) | weight:length of humerus | Male | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ all doses (by 60 d of age) | weight:length of humerus | Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effect | organ wt:body wt ratios | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | 1.0-22.7 (liver), 2.7-74.4 (kidney) ppm, wet wt | Ni concentrations (ranges) in liver and kidney in ducklings that died @ 1200 ppm | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-EXP IND - accumulation | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | mortality versus controls | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-MORT - dose-response data | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | body wt, hematocrit, hemoglobin, food consumption versus controls | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - whole animal | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 2.116 (@ 2 ppm), 19.510 (@ 20 ppm), 96.600 9@ 200 ppm) ppm, wet wt | mean Cd concentrations in liver after 90 d of treatment | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm diet | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 4.627 (@ 2 ppm), 54.333 (@ 20 ppm), 77.222 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in kidneys after 90 d of treatment | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased to 0.010 (@ 20 ppm), 0.040 (@ 200 ppm) ppm, wet wt | Cd concentrations in eggs versus controls | Both Male and Female | Adult | 15 eggs (20 ppm), 3 eggs (200 ppm) | 0,20,200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm/60 or 90 d of treatment, 30 d post-treatment | mean kidney weight versus controls | Both Male and Female | Adult | 10 kidneys/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | decreased @ all doses/30 d post-treatment, and 200 ppm/90 d of treatment | mean testis weight versus controls | Male | Adult | 5 testes/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SALINE WATER | decreased @ 4000 or 7720 umhos/cm | body weight by day 14 or 16 versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control), less saline water (3750-7490 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 28 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased | plasma protein levels; serum osmolality; salt, kidney and adrenal gland size versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control), less saline water (3750-7490 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 14-28 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased @ 67,000 umhos/cm (100%), 35,000 umhos/cm (100%), 21,500 umhos/cm (78%), and 20,000 umhos/cm (60%) | mortality versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-MORT - dose-response data | 14 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased @ 20,000 umhos/cm and above | thymus size versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - organ/system effects | 14 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | decreased @ 20,000 and 21,500 umhos/cm | body weight by day 14 versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 14 d | drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | increased @ 0.5, 3 ppm | changes in approach behavior (maternal call stimulus) | Not Reported | Juvenile | 249 (control); 276 (0.5 ppm); 108 (3 ppm) | 0,0.5,3 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | incubation period | parental diet (in ovo) | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | increased @ 0.5, 3 ppm | changes in avoidance behavior (frightening stimulus) | Not Reported | Juvenile | 319 (control); 339 (0.5 ppm); 158 (3 ppm) | 0,0.5,3 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | incubation period | parental diet (in ovo) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | mean egg weight compared to controls | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | 1 (@ 0.5 ppm), 6.46-9.19 (@ 3 ppm) ppm in eggs | mercury concentrations in eggs (at plateau) | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | decreased @ 0.5, 3 ppm | duration of egg production compared to controls | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | hatching success and 1 wk survival of hatchlings compared to controls | Not Reported | Juvenile | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | duckling survival | Not Reported | Juvenile | Not Reported | 0, 0.5, 3 ppm diet | TOX-REPRO - reproductive success | 3-15 mos | parental diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | increased @ 3 ppm | incidence of brain lesions (demyelination, necrosis, neuronal shrinkage) | Not Reported | Juvenile | 3-11 ducklings/group | 0, 0.5, 3 ppm diet | TOX-REPRO - development | 3-15 mos | parental diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.4 +/- 0.18 (@ 1 ppm, no DDE), 8.7 +/- 0.87 (@ 5 ppm, no DDE) ppm Hg, wet wt | mean Hg concentration in third egg laid in clutch (mean +/- SE) | Female | Adult | 10/group | 1, 5 ppm Hg; both doses given with and w/out 5 ppm DDE | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
DDE (4,4'-), METHYLMERCURY CHLORIDE | 1.0 +/- 0.06 (@ 1 ppm Hg, no DDE), 5.3 +/- 0.56 (@ 5 ppm Hg, no DDE) ppm Hg, wet wt | Hg concentration in breast muscle (mean +/- SE) | Female | Adult | 10/group | 1, 5 ppm Hg; both doses given with and w/out 5 ppm DDE | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE | increased @ 1,3,9,27,90 ug Hg | % abnormal survivors by day 18 of incubation versus controls | Both Male and Female | Embryo | 80 eggs/group | 0,0.3,1,3,9,27,90 ug Hg | TOX-REPRO - development | single | application to shell surface | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE | decreased @ 27, 90 ug Hg | embryo crown to rump length by day 18 of incubation versus controls | Both Male and Female | Embryo | 80 eggs/group | 0,0.3,1,3,9,27,90 ug Hg | TOX-REPRO - development | single | application to shell surface | Toxicity Factor Datasets |
METHYLMERCURY CHLORIDE | decreased @ 9, 27, 90 ug Hg | % survival by day 18 of incubation versus controls | Both Male and Female | Embryo | 80 eggs/group | 0,0.3,1,3,9,27,90 ug Hg | TOX-REPRO - reproductive success | single | application to shell surface | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY CHLORIDE | decreased | hatchability versus controls | Not Reported | Juvenile | 29 pairs | 8 mg Hg | TOX-REPRO - reproductive success | 2 doses @ 2 wk interval (eggs collected beginning after 1st dose) | oral (capsule) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | see figure and table | figure and table showing decline of Hg in carcass, liver, and kidney over time | Male | Adult | 3-5 birds/group | 8 ppm diet | TOX-EXP IND - accumulation | 2 wks | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | 9.10 (whole body), 4.46 (carcass), 16.5 (liver), 17.6 (kidney) ppm, wet wt | mean Hg concentrations after 2 wk exposure | Male | Adult | 3-5 birds/group | 8 ppm diet | TOX-EXP IND - accumulation | 2 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | 13-20 ppm, wet wt | mean Se concentration in eggs | Female | Adult | 5 birds | 15 ppm diet | TOX-EXP IND - accumulation | 20 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm as Se-met or yeast, or 15 ppm as wheat | food consumption compared to controls | Not Reported | Juvenile | 25 birds/group | 0,15,30 ppm diet (as Se-L-met, Se-DL-met, yeast), or 15 ppm as wheat | TOX-Non-Repro-Sublethal - behavioral effects | 2 wks | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm as Se-met or yeast | body weight compared to controls | Not Reported | Juvenile | 25 birds/group | 0,15,30 ppm diet (as Se-L-met, Se-DL-met, yeast), or 15 ppm as wheat | TOX-Non-Repro-Sublethal - whole animal | 2 wks | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm as Se-L-met | survival rate compared to controls | Not Reported | Juvenile | 25 birds/group | 0,15,30 ppm diet (as Se-L-met, Se-DL-met, yeast), or 15 ppm as wheat | TOX-MORT - dose-response data | 2 wks | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS, SELENOMETHIONINE | 11-12 (@ 15 ppm as Se-met or wheat), 6.2 (@ 15 ppm as yeast), 19-20 (@ 30 ppm as Se-met or wheat), 9.9 (@ 30 ppm as yeast) ppm, wet wt | mean concentrations of Se in livers | Not Reported | Juvenile | 25 birds/group | 0,15,30 ppm diet (as Se-L-met, Se-DL-met, yeast), or 15 ppm as wheat | TOX-EXP IND - accumulation | 2 wks | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm (as Se-met or yeast) | food consumption compared to controls | Not Reported | Juvenile | 25 birds/group | 0,30 ppm diet (as Se-L-met, Se-DL-met, yeast) | TOX-Non-Repro-Sublethal - behavioral effects | 2 wks | diet | Toxicity Factor Datasets |
SELENIUM COMPOUNDS, SELENOMETHIONINE | decreased @ 30 ppm (as Se-met or yeast) | body weights compared to controls | Not Reported | Juvenile | 25 birds/group | 0,30 ppm diet (as Se-L-met, Se-DL-met, yeast) | TOX-Non-Repro-Sublethal - whole animal | 2 wks | diet | Toxicity Factor Datasets |