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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE, LEAD CHLORIDE | 4.1 (0.5) @ 10 ppm Pb; 22.5 (1.5) @ 100 ppm Pb; 3.1 (0.3) @ 5 ppm Cd + 5 ppm Pb; 16.1 (1.4) @ 50 ppm Cd+ 50 ppm Pb (ug/g, dry wt) | mean (SE) Pb concentrations in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, COPPER COMPOUNDS, LEAD CHLORIDE | 56.7(7.7) @ 100 ppm Cd; 37.7 (3.7) @ 50 ppm Cd + 50 ppm Pb (ug/g, dry wt) | mean (SE) Cu concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, LEAD CHLORIDE, ZINC COMPOUNDS | 99 (6) @ 110 ppm Cd; 125 (7) @ 100 ppm Cd; 100 (5) @ 5 ppm Cd + 5 ppm Pb; 112 (2) @ 50 ppm Cd + 50 ppm Pb | mean (SE) Zn concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | increased @ 200 ppm | weight of kidneys versus controls | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | decreased @ 200 ppm | weight of testes versus controls | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm | incidence of kidney lesions versus controls | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm | incidence of testes alterations (atrophy, decreased spermatogenesis) versus controls | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 0.46 (@ 0 ppm), 4.63 (@ 2 ppm), 54.33 (@ 20 ppm), 77.22 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in kidneys (ppm, wet wt) by 90 days | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 0.03 (@ 0 ppm), 0.02 (@ 2 ppm), 0.72 (@ 20 ppm) 8.47 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in testes (ppm, wet wt) by 90 days | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM, SELENOMETHIONINE | increased (40%) @ 60 ppm Se | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | incidence of ducklings with histopathological lesions versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | decreased @ 60 ppm Se, 200 ppm As | growth rate of body weight versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with or 22% protein in diet) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | glutathione peroxidase activity versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased (100%) @ 60 ppm Se and (53%) @ 200 ppm As | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 7% protein in diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | survival rate versus controls | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-MORT - dose-response data | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | decreased @ 30, 100, 300 ppm | growth rate versus controls | Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | decreased @ 300 ppm | growth rate versus controls | Male | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | no effect | incidence of histopathological lesions, and liver, brain, and spleen weights | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 300 ppm | plasma biochemistry changes versus controls | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 10, 100, 300 ppm | plasma concentration of triglycerides | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 10, 100, 300 ppm | incidence of altered brain and liver biochemistry | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 100 ppm ( 0.3 ppm, dry wt), 300 ppm (1.3 ppm, dry wt) | arsenic concentrations in liver (geometric means in parentheses) | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | decreased @ 1000 ppm Al (LH, LL), 5000 ppm Al (NN) | body weight growth versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased @ 1000 (LL), 1000 (LH), 5000 ppm (LH) | growth of body components (tarsus, culmen) versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | increased to 61% @ 1000 (LL), 100% @ 5000 (LL) | mortality versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased @ 1000 (LL) | food consumption versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - behavioral effects | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | see table | Ca, Al, P concentrations in femur for different treatments after 2 and 10 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased on LL and LH diets | femur mass and mean breaking force (LL, LH vs. NN diets) after 2 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased with LL and LH diets | femur breaking strength (LL,LH vs. NN diets) after 10 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | increased in LL diets | incidence of clinical signs (LL vs. LH vs. NN diets) | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
STEEL COMPOUNDS, TRIBUTYLTIN | increased in both groups (no treatment diffs) | white blood cell counts, monocyte counts, total protein concentrations over study period | Both Male and Female | Juvenile | 20/group | three #4 steel shot or three #4 tributyltin shot implants | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1-8 wks | intramuscular | Toxicity Factor Datasets |
STEEL COMPOUNDS, TRIBUTYLTIN | increased with steel shot, wk 8 | overall response score (inflammation, muscle damage changes) | Both Male and Female | Juvenile | 20/group | three #4 steel shot or three #4 tributyltin shot implants | TOX-Non-Repro-Sublethal - whole animal | 1-8 wks | intramuscular | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 200, 800 ppm | food consumption compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | body wt, liver wt:brain wt, kidney wt:brain wt, duodenal wt compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | plasma biochemistry compared to controls | Male | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | reproductive success (number of eggs laid, hatchability, duckling survival) compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-REPRO - reproductive success | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | increased @ 12.5, 50, 200, 800 ppm diet | kidney, blood, liver, and feather concentrations of Ni compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-EXP IND - accumulation | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | 1.94 (kidney), 0.52 (liver), 0.139 (blood), 68.06 (feathers) ppm, wet wt | mean tissue concentrations @ 800 ppm Ni in diet | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-EXP IND - accumulation | 90 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 800, 1200 ppm | incidence of clinical signs and mortality | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-MORT - dose-response data | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ 1200 ppm | body wt by 28 d of age | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |