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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Pb, no effect with Fe or Bi | mortality versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-MORT - dose-response data | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Pb; no effect with Fe or Bi | body weight, gonad weight, hematocrit versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - whole animal | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Pb; no effect with Fe or Bi | gizzard and kidney weight versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - organ/system effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Pb | liver weight versus controls (females only) | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - organ/system effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | onset of lay and time to lay 21 eggs versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Fe | weight of eggs that hatched versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | increased with Bi | weight of eggs that did not hatch versus controls | Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - physiology | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | decreased with Bi | weight of hatchlings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | survival to 7 d, organ histopathology, hematocrit, sex ratios, kidney or liver weights of ducklings versus controls | Both Male and Female | Juvenile | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | egg weight, eggshell thickness, fertility, hatchability versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-REPRO - reproductive success | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | no effect with Fe or Bi | histopathology of kidney, liver, testis, heart, lung versus controls | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-Non-Repro-Sublethal - cellular/biochemical effects | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 213(27.1) ppm, kidney; 91(4.55) ppm, liver; 9.8(3.22) ppm, ovary; 3.49(0.61) ppm, testis | mean(SE) wet wt concentrations of Pb in Pb-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 237(17.2) ppm, kidney; 1936(233) ppm, liver; 90.6(6.85) ppm, ovary; 13.1(1.29) ppm, testis | mean(SE) wet wt concentrations of Fe in Fe-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
BISMUTH COMPOUNDS, IRON COMPOUNDS, LEAD (elemental) | 1.54(0.280) ppm, kidney; 0.637(0.134) ppm, liver; 0.042(0.007) ppm, ovary; 0.098(0.042) ppm, testis | mean(SE) wet wt concentrations of Bi in Bi-dosed birds | Both Male and Female | Adult | 18 pairs/group (control, Fe, Bi); 6 pairs/Pb group | 0, eight #4 iron, bismuth, or lead shot, administered on Days 1, 30, 60, 90; see paper for dissolution and retention of shot in gizzards of treated birds | TOX-EXP IND - accumulation | up to 150 d | oral gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | blood ALAD enzyme activity after 1,2, or 3 months versus pre-dose controls | Both Male and Female | Adult | laboratory | 20 per sex | 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single exposure | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased | blood Pb concentrations versus pre-dose controls | Both Male and Female | Adult | laboratory | 20 per sex | 1 lead shot (no. 4) | TOX-EXP IND - accumulation | single exposure | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CYANOFENPHOS | increased | incidence of delayed neurotoxicity signs | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased (30% @ 10 mg leptophos/kg/d; 10% @ 0.5 mg cyanofenphos/kg/d; 0% @ 1.0 mg cyanofenphos/kg/d; 20% @ 2.0 mg cyanofenphos/kg/d ;60% @ 4.0 mg cyanofenphos/kg/d; 100% @ 8.0 mg cyanofenphos/kg/d | mortality versus controls) | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-MORT - dose-response data | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | decreased @ 2.0, 4.0 mg/kg/d | bw versus controls | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased @ 2.0, or 4.0 mg cyanofen/kg/d, 10 mg leptophos/kg/d. | incidence of histological lesions in axons and myelin sheaths | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | 90 days | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | decreased | incidence of delayed hypersensitivity reactions to antigen versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 2.2 mg Se/L | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | decreased | blood monocyte counts after 78 days exposure versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 0.5, 3.5 mg Se/L (sodium selenite); 2.2 mg Se/L (selenomethionine) | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 3.5 mg/L (selenite) or 2.2 mg/L (selenomethionine) | serum ALT enzyme activity versus controls n high selenite and selenomethionine groups. | Male | Adult | laboratory | Controls = 24 Treated = 8 | 0, 3.5 mg Se/L (as sodium selenite); 2.2 mg Se/L (selenomethionine) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 12 weeks | drinking water | Toxicity Factor Datasets |
SELENOMETHIONINE | increased (12-fold) | selenium concentrations in pectoral muscle | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 2.2 mg Se/L | TOX-EXP IND - accumulation | 12 weeks | Drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | hemoglobin and hematocrit versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - organ/system effects | Single exposure | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | decreased (60%) | blood ALAD activity versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Single exposure | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased | blood protoporphyrin levels versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Single exposure | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 5 shot (33%) and repeated 5 shot (40%) | percent mortality versus controls | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-MORT - dose-response data | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | decreased | bw versus controls | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-Non-Repro-Sublethal - whole animal | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased @ all doses | Pb concentrations in wing bone and liver | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-EXP IND - accumulation | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | liver: C = 7.4(1-e^-0.382t) muscle: C = 8.0(1-e^-0.037t) | selenium accumulation equations | Both Male and Female | Adult | 3 | 10 ppm Se | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
SELENOMETHIONINE | liver: C = 7.4e^-0.037t muscle: C = 5.6e^-0.023t liver at peak body burden: C = 22.6e^-0.246t + 2.5 e^-0.008t muscle at peak body burden: C = 6.4e^-0.029t Loss phase for blood at peak body burden: C = 12.0e^-0.071t | selenium depuration equations | Both Male and Female | Adult | 3 | 10 ppm, doubled weekly, Se | TOX-EXP IND - accumulation | 28 days | Diet | Toxicity Factor Datasets |
SELENOMETHIONINE | liver: 18.7 d muscle: 30.1 d | half life of selenium in tissues | Both Male and Female | Adult | 3 | 10 ppm Se | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decreased @ 5 uL/egg | embryonic weight (females) and crown rump length (both sexes) | Both Male and Female | Hatchling | 65 eggs/group | 0, 1, or 5 uL | TOX-REPRO - development | Single exposure | Topical on eggshell | Toxicity Factor Datasets |
CRUDE OILS | decreased to 65% @ 1 uL/egg); 9% @ 5 uL/egg | embryo survival to 18 days | Both Male and Female | Embryo | 65 eggs/group | 0, 1, or 5 uL | TOX-REPRO - development | Single exposure | Topical on eggshell | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 15 ppm, 60 ppm (adequate protein, no methionine added) | incidence of histopathological changes in livers versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - organ/system effects | 4 weeks | Dietary | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 60 ppm (regardless of methionine suppl. or protein levels) | body, liver and spleen weights, and tarsus length versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - whole animal | 4 weeks | Dietary | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 15 (GSH-peroxidase only), 60 ppm Se, adequate protein | plasma GSH-peroxidase and alkaline phosphatase activities versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 weeks | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | no effect | distance run in 2 seconds from a fright stimulus vs controls | Not Reported | Chick | 32, 14, 14, 14, 11 in the 0, 1, 2, 4, and 8 ppm groups | 0, 1, 2, 4, or 8 ppm Se | TOX-Non-Repro-Sublethal - behavioral effects | 4 weeks (parents) | parental diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decreased | % normal hatchlings versus controls | Not Reported | Embryo | 492-518, 232-384, and 128-276 for the 0, 10, and 40 ppm DDE groups | 0, 10, or 40 ppm | TOX-REPRO - development | 2 years | Diet | Toxicity Factor Datasets |