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Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
see citation tables | incidence of reduced growth and abnormal survivors for 42 compounds | Not Reported | Embryo | 30 eggs/group | see citation for doses of 42 compounds | TOX-REPRO - development | single | eggshell surface application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | decreased @ 90, 270 ppm | food consumption and body weight compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
EPN | increased @ all doses | incidence of hyperactivity, ataxia, and/or paralysis compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
EPN | increased @ 30, 90, 270 ppm | incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
EPN | decreased @ all doses | activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
EPN | decreased @ 90, 270 pmm | plasma alkaline phosphatase activity compared with controls | Female | Juvenile | 6/group | 0, 10, 30, 90, 270 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 270, 540 ppm | body weight compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | increased @ all doses | incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 270 ppm | brain weight compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - organ/system effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ all doses | activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
LEPTOPHOS | decreased @ 60, 270 ppm | plasma alkaline phosphatase activity compared with controls | Female | Juvenile | 6/group | 0, 60, 270, 540 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease | % fertile eggs and # of ducklings; when male, female or both male and female exposed to oil, compared to control | Female | Adult | 3 pairs/dose | 0 or 3 ml S. Louisiana crude oil/ 100 g dry wt. food | TOX-REPRO - reproductive success | 100 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase | metabolic heat production (watts/kg), compared to pre-contamination levels | Not Reported | Adult | 3/dose | 0.1 or 0.4 ml Statfjord crude oil with Finasol OSR-5 or OSR-12 dispersant/L water | TOX-Non-Repro-Sublethal - whole animal | 1 d | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | 53% increase | plasma triiodothryonine concentration | Not Reported | Adult | 5/dose | control or 5 ml Statfjord crude oil/kg/d | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 6 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | 56% increase | hepatic cytochrome P450 content | Not Reported | Adult | 5/dose | control or 5 ml Statfjord crude oil/kg/d | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 6 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | no effect | body weight | Not Reported | Adult | 5/dose | control or 5 ml Statfjord crude oil/kg/d | TOX-Non-Repro-Sublethal - whole animal | 6 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIISOPROPYL METHYLPHOSPHONATE | decrease | mean blood pressure, compared to baseline prior to exposure | Both Male and Female | Adult | 12 | 1500 mg/kg | TOX-Non-Repro-Sublethal - whole animal | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DDT (4,4'-) | see citation | figure of eggshell thickness over 30 d period (significant differences noted at various times) | Female | Adult | 20/dose | 0, 10, 50 ppm DDT, DDE, DDT-SO4 or DDE-SO4 | TOX-REPRO - physiology | 30 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | 13.8% decrease | eggshell thickness, compared to controls | Female | Adult | 3/dose | 0, 75 ppm | TOX-REPRO - physiology | 7 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | decreased | eggshell weight and thickness, total eggshell calcium and shell gland epithelial microsomal Ca-ATPase activity, compared to controls | Female | Adult | 5 hens/dose; 19 eggs/dose | 0, 50 ppm | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LINDANE | serum (0.13); fat (0.20); muscle (0.70); kidney (0.02); liver (0.02); brain (0.01) ppm @ 20 mg/kg 2x/wk | mean lindane residue levels | Female | Adult | 5/dose | 20 mg/kg given 7x, 3x or 2x per wk | TOX-EXP IND - accumulation | 8 wks | gavage | Toxicity Factor Datasets |
LINDANE | serum (0.20); fat (0.68); muscle (0.30); kidney (0.23); liver (0.14); brain (0.11) ppm @ 20 mg/kg 3x/wk | mean lindane residue levels | Female | Adult | 5/dose | 20 mg/kg given 7x, 3x or 2x per wk | TOX-EXP IND - accumulation | 8 wks | gavage | Toxicity Factor Datasets |
LINDANE | serum (0.50); fat (1.14); muscle (0.82); kidney (0.28); liver (0.21); brain (0.13) ppm @ 20 mg/kg 7x/wk | mean lindane residue levels | Female | Adult | 5/dose | 20 mg/kg given 7x, 3x or 2x per wk | TOX-EXP IND - accumulation | 8 wks | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | no effect | food consumption rate (174 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | 0, 40 ppm | TOX-Non-Repro-Sublethal - behavioral effects | 50 - 52 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | food consumption rate (184 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | 0, 40 ppm | TOX-Non-Repro-Sublethal - behavioral effects | 50 - 52 d | diet | Toxicity Factor Datasets |
AROCLOR 1254, DDE (4,4'-) | no effect | food consumption rate (181 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | 0, 40 ppm DDE + 40 ppm PCB | TOX-Non-Repro-Sublethal - behavioral effects | 50 - 52 d | diet | Toxicity Factor Datasets |
AROCLOR 1254 | no effect | eggshell thickness | Female | Adult | 10 hens/dose; 8-9 eggs/dose | 0, 40 ppm | TOX-REPRO - physiology | 50 - 52 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 17% decrease | eggshell thickness, compared to control | Female | Adult | 10 hens /dose; 8 eggs/dose | 0, 40 ppm | TOX-REPRO - physiology | 50 - 52 d | diet | Toxicity Factor Datasets |
AROCLOR 1254, DDE (4,4'-) | 19% decrease | eggshell thickness, compared to control | Female | Adult | 10 hens/dose; 8 eggs/dose | 0, 40 ppm DDE + 40 ppm PCB | TOX-REPRO - physiology | 50 - 52 d | diet | Toxicity Factor Datasets |
AROCLOR 1254, DDE (4,4'-) | see citation | figure of # eggs/female/wk over time | Female | Adult | 10/dose | 0, 40 ppm DDE + 40 ppm PCB | TOX-REPRO - reproductive success | 50 - 52 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 373 (95% CL; 152-574) ppm lipid basis @ 40 ppm diet | DDE residue concentrations in eggs | Female | Adult | 12 | 0, 40 ppm DDE | TOX-EXP IND - accumulation | 8-94 d | diet | Toxicity Factor Datasets |
AROCLOR 1254, DDE (4,4'-) | 344 (95% CL; 156-686) ppm DDE lipid basis and 346 (95%CL; 133-686) ppm PCB lipid basis @ 40 ppm DDE + 40 ppm PCB diet | mean DDE and PCB residue levels in eggs | Female | Adult | 13 | 0, 40 ppm DDE + 40 ppm PCB | TOX-EXP IND - accumulation | 7-128 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
VANADYL SULFATE | no effect | body weight and food consumption compared among groups | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | increased @ 100 ppm (maximum = 106 +/- 19 ppb, wet wt) | vanadium concentration in blood (sampled at 3 wk intervals) | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | brain, 9(1); fat, 20(11); kidney, 273(49); liver, 657(113), male femur 274(47); female femur 3327(2208) ppm, wet wt | mean (SE) vanadium concentrations @ 100 ppm dose in brain, fat, kidney, liver, and femur | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | <0.02 ppb, wet wt @ 1, 10 ppm; 63 ppb, wet wt @ 100 ppm | vanadium concentration in eggs | Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-EXP IND - accumulation | 12 wks | diet | Toxicity Factor Datasets |
VANADYL SULFATE | increased @ 100 ppm | plasma cholesterol levels in drakes and laying hens | Both Male and Female | Adult | 5 pairs/group | 0, 1, 10, 100 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 12 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | increase @ 2-15 ul/egg | percent mortality versus controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - reproductive success | single | application to egg surface | Toxicity Factor Datasets |
CRUDE OILS | increase @ 2-15 ul/egg | incidence of survivors with abnormalities versus controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - development | single | application to egg surface | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 15 ul/egg | red blood cell and liver ALAD activity and hemoglobin concentration, compared to controls | Both Male and Female | Embryo | 100 eggs/dose | 0, 2, 5, 15 ul waste crankcase oil/egg | TOX-REPRO - physiology | single | application to egg surface | Toxicity Factor Datasets |