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| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | 1.13 ppm blood at 212 ppm; 1.69 ppm blood at 448 ppm | mean lead concentration in blood | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 7.84 ppm femur at 120 ppm; 16.60 ppm femur at 212 ppm; 18.44 ppm femur at 448 ppm | mean lead concentration in femur | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | no effect | packed cell volume, hemoglogin concentration, erythrocyte counts | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 60 d | diet | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 1.05 (0.05 SE) ppm (wet wt) | lead concentration in liver | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 0.70 (0.20 SE) ppm (wet wt) | lead concentration in tibia | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 232 (9 SE) ppm (wet wt) | DDE concentration in carcass | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 10.4 (0.6 SE) ppm (wet wt) | DDE concentration in brain | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | decreased | bw (versus pre-study bw) | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-Non-Repro-Sublethal - whole animal | 60 d | diet | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | 0.357 (0.012 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 7.63 (1.03 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in bone | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | 0.24 ug/g at study area, 0.087 ug/g at reference area | mean lead concentration in blood (wet wt) | Both Male and Female | Nestling | Coeur D'Alene River | 30 (study area) 22 (reference) | 3.0-1640 ug/g (wet wt) in prey species | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 0.46 ug/g at study area 0.25 ug/g at reference area | mean lead concentration in blood (wet wt) | Both Male and Female | Adult | Coeur D'Alene River | 3 (study area) 6 (reference) | 3.0-1640 ug/g (wet wt) in prey species | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | decreased | red blood cell delta aminolevulinic acid dehydratase activity (relative to control) | Both Male and Female | Both Adults and Juveniles | Coeur D'Alene River | 33 | 3.0-1640 ug/g (wet wt) in prey species | TOX-EXP IND - biomarkers | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | decreased | hematocrit | Both Male and Female | Juvenile | Coeur D'Alene River | 30 | 3.0-1640 ug/g (wet wt) in prey species | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | decreased | hemoglobin (relative to control) | Both Male and Female | Both Adults and Juveniles | Coeur D'Alene River | 33 | 3.0-1640 ug/g (wet wt) in prey species | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 0.23 ug/g (wet wt) | mean lead concentration in liver | Both Male and Female | Juvenile | Coeur D'Alene River | 30 | 3.0-1640 ug/g (wet wt) in prey species | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | no effect | number of young produced | Both Male and Female | Adult | Coeur D'Alene River | 20 nests | 3.0-1640 ug/g (wet wt) in prey species | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ARSENIC COMPOUNDS, CADMIUM COMPOUNDS, COPPER COMPOUNDS, LEAD COMPOUNDS, ZINC COMPOUNDS | Arsenic, <0.02; Cadmium, 0.08; Copper, 3.4; Lead, <0.003; Zinc, 29.5 ug/g | mean carcass concentration (ug/g wet wt.); mean deer mice body weight = 36.0 +/- 8.3SD, n=8 | Not Reported | Not Reported | Milltown Reservoir, Missoula | 8 animals | Mining waste; Mean soil concentrations (n=8): Arsenic, 52.5 +/- 6.2; Cadmium, 7.8 +/- 0.7; Copper, 532.2 +/- 69.4; Lead, 65.7 +/- 6.4; Zinc, 1,908.9 +/- 392.9SE ug/g | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | Bone; 52.10 +/- 33.81SD, Kidney; 8.46 +/- 3.03SE, Liver; 3.29 +/- 1.77SD, Brain; 0.84 +/- 0.25SE, Feces; 153.6+/- 103.5SD ppm (dry weight) | Mean concentrations in deer mice from roadside site (ppm, dry weight). Feces collected from nest box after 1 yr accumulation. Roadside tissue concentrations significantly different from control site. | Both Male and Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 9 - 10 animals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-EXP IND - accumulation | NR | multiple | Toxicity Factor Datasets |
| LEAD COMPOUNDS | no effect | number of litters per 100 breeding females, measured by observing litters in nesting boxes at a control and roadside site | Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 50 nesting boxes, 66 observation periods nimals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
| LEAD COMPOUNDS | significant increase | mortality during winter, estimated by number of mice recaptured the following breeding season at a control and roadside site | Both Male and Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 98 - 180 tagged animals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-MORT - mortality in the field | NR | multiple | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CADMIUM COMPOUNDS, LEAD COMPOUNDS, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS, SELENIUM COMPOUNDS | no effect | incidence of liver and kidney histopathologies was not related to contaminant concentrations | Not Reported | Not Reported | salt marsh, San Pablo and San Francisco Bays | 26 animals | Range of tissue means (ppm, dry wt.): Liver; 0.05-1.08 (mercury), 2.32-3.53 (selenium). Kidney; 0.4-2.11 (cadmium), 0.6-1.92 (lead). Carcass; 0.02-0.22 (PCBs). | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, LEAD COMPOUNDS, SELENIUM COMPOUNDS, ZINC COMPOUNDS | increase | incidence of epileptiform seizures and subsequent death associated with "unusual" Se levels | Female | Adult | 1 | range of metal residue levels in brain, liver, heart, muscle and fat (ppm dry wt); Cd, 0.18 - 3.03; Cr, 1.24-2.39; Cu 1.86 - 87.74; Pb, 77.21-110.90; Se 222-255; Zn 4.89-240.28 | TOX-Non-Repro-Sublethal - whole animal | NR | site contamination | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| DDE (4,4'-), LEAD COMPOUNDS, MERCURY COMPOUNDS | decreased @ 40 ppm DDE | eggshell thickness versus controls | Female | Adult | 10/group | 0, 40 ppm DDE, 100 ppm lead, or 200 ppm N-(ethylmercury)-p-toluene sulfoanilide | TOX-REPRO - physiology | 55 d - approx. 2 mos | diet | Toxicity Factor Datasets |
| DDE (4,4'-), LEAD COMPOUNDS, MERCURY COMPOUNDS | decreased with both treatments | eggshell thickness versus controls | Female | Adult | 10/group | 0, 40 ppm DDE + 100 ppm lead, or 40 ppm DDE + 200 ppm N-(ethylmercury)-p-toluene sulfoanilide | TOX-REPRO - physiology | 55 d - approx. 2 mos | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 3.7 (carcass); 2.5 (egg); 2.5 (eggshells); 9.6 (bone) ppm, wet wt @ 100 ppm lead; 3.4 (carcass); 0.88 (egg); 2.8 (eggshells); 35.0 (bone) ppm, wet wt @ 100 ppm lead + DDE | lead residues in whole carcass, egg contents, eggshells, and bone | Female | Adult | 10/group | 100 ppm lead, or 40 ppm DDE + 100 ppm lead | TOX-EXP IND - accumulation | approx. 2 mos | diet | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | 0.822 (0.059-21.60) ppm wet wt | geometric mean liver concentration (range) | Not Reported | Not Reported | Ebro Delta Natural Park | 39 birds | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 1.367 (<0.05-29.80) | geometric mean concentration in kidneys (range) | Not Reported | Not Reported | Ebro Delta Natural Park | 39 birds | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
| LEAD COMPOUNDS | humerus, 41.652 (8.20-211.6); spleen, 0.669 (0.128-2.397); pancreas, 3.295 (1.074-13.47); brain, 1.367 (0.120-117.1) | geometric mean concentrations (ranges) in humerus, spleen, pancreas, and brain | Not Reported | Not Reported | Ebro Delta Natural Park | 6-10 birds/tissue type | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
| Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| LEAD COMPOUNDS | no effect | body weight versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | reduced @ 828 ug/g | hemoglobin concentrations versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | reduced @ all doses | delta aminolevulinic acid dehydratase activity versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | increased @ 414, 828 ug/g | occurrence of intranuclear inclusion bodies in kidneys versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | increased @ 828 ug/g | occurrence of lead poisoning signs versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | increased @ all doses | protoporphyrin levels in blood versus controls | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | 4.6(0.66) ppm @ 103 ug/g Pb; 9.3(0.82) ppm @ 207 ug/g Pb; 12(1.3) ppm @ 414 ug/g Pb; 28(4.6) ppm @ 828 ug/g Pb | mean(SE) wet wt concentrations of lead in liver | Male | Adult | 10/ Pb treatment; 20/control treatment | 0, 1.5 (sediment control), 103, 207, 414, 828 ug/g calculated diet concentrations, added as contaminated sediment | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | no effect | body weight versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | reduced @ 624 and 1284 ug/g | delta aminolevulinic acid dehydratase activity and hemoglobin concentrations | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | increased @ 642 and 1284 ug/g | protoporphyrin versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
| LEAD COMPOUNDS | reduced @ 1284 ug/g | hematocrit versus controls | Male | Adult | 10/ Pb treatment; 5/control treatment | 0, 8.7 (sediment control), 642, 1284 ug/g diet, added as contaminated sediment | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |