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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CYANOFENPHOS | increased | incidence of delayed neurotoxicity signs | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased (30% @ 10 mg leptophos/kg/d; 10% @ 0.5 mg cyanofenphos/kg/d; 0% @ 1.0 mg cyanofenphos/kg/d; 20% @ 2.0 mg cyanofenphos/kg/d ;60% @ 4.0 mg cyanofenphos/kg/d; 100% @ 8.0 mg cyanofenphos/kg/d | mortality versus controls) | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-MORT - dose-response data | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | decreased @ 2.0, 4.0 mg/kg/d | bw versus controls | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - whole animal | 90 days | gavage | Toxicity Factor Datasets |
CYANOFENPHOS | increased @ 2.0, or 4.0 mg cyanofen/kg/d, 10 mg leptophos/kg/d. | incidence of histological lesions in axons and myelin sheaths | Both Male and Female | Juvenile | laboratory | 10 | 0, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg/d | TOX-Non-Repro-Sublethal - organ/system effects | 90 days | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | decreased | incidence of delayed hypersensitivity reactions to antigen versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 2.2 mg Se/L | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | decreased | blood monocyte counts after 78 days exposure versus controls | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 0.5, 3.5 mg Se/L (sodium selenite); 2.2 mg Se/L (selenomethionine) | TOX-Non-Repro-Sublethal - organ/system effects | 12 weeks | Drinking water | Toxicity Factor Datasets |
SELENITE, SODIUM, SELENOMETHIONINE | increased @ 3.5 mg/L (selenite) or 2.2 mg/L (selenomethionine) | serum ALT enzyme activity versus controls n high selenite and selenomethionine groups. | Male | Adult | laboratory | Controls = 24 Treated = 8 | 0, 3.5 mg Se/L (as sodium selenite); 2.2 mg Se/L (selenomethionine) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 12 weeks | drinking water | Toxicity Factor Datasets |
SELENOMETHIONINE | increased (12-fold) | selenium concentrations in pectoral muscle | Male | Adult | Laboratory | Controls = 24 Treated = 8 | 0, 2.2 mg Se/L | TOX-EXP IND - accumulation | 12 weeks | Drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decreased | hemoglobin and hematocrit versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - organ/system effects | Single exposure | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | decreased (60%) | blood ALAD activity versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Single exposure | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased | blood protoporphyrin levels versus controls | Male | Juvenile | Laboratory | 8 | 0, 1 lead shot (no. 4) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Single exposure | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | increased @ 5 shot (33%) and repeated 5 shot (40%) | percent mortality versus controls | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-MORT - dose-response data | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | decreased | bw versus controls | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-Non-Repro-Sublethal - whole animal | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
LEAD (elemental) | increased @ all doses | Pb concentrations in wing bone and liver | Both Male and Female | Not Reported | 5-6/group | 0, 2, 5, 5 (w/5 repeated doses) Pb shot (no. 6) | TOX-EXP IND - accumulation | Single dose, except for repeated dose group | Gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | liver: C = 7.4(1-e^-0.382t) muscle: C = 8.0(1-e^-0.037t) | selenium accumulation equations | Both Male and Female | Adult | 3 | 10 ppm Se | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
SELENOMETHIONINE | liver: C = 7.4e^-0.037t muscle: C = 5.6e^-0.023t liver at peak body burden: C = 22.6e^-0.246t + 2.5 e^-0.008t muscle at peak body burden: C = 6.4e^-0.029t Loss phase for blood at peak body burden: C = 12.0e^-0.071t | selenium depuration equations | Both Male and Female | Adult | 3 | 10 ppm, doubled weekly, Se | TOX-EXP IND - accumulation | 28 days | Diet | Toxicity Factor Datasets |
SELENOMETHIONINE | liver: 18.7 d muscle: 30.1 d | half life of selenium in tissues | Both Male and Female | Adult | 3 | 10 ppm Se | TOX-EXP IND - accumulation | 42 days | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decreased @ 5 uL/egg | embryonic weight (females) and crown rump length (both sexes) | Both Male and Female | Hatchling | 65 eggs/group | 0, 1, or 5 uL | TOX-REPRO - development | Single exposure | Topical on eggshell | Toxicity Factor Datasets |
CRUDE OILS | decreased to 65% @ 1 uL/egg); 9% @ 5 uL/egg | embryo survival to 18 days | Both Male and Female | Embryo | 65 eggs/group | 0, 1, or 5 uL | TOX-REPRO - development | Single exposure | Topical on eggshell | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | increased @ 15 ppm, 60 ppm (adequate protein, no methionine added) | incidence of histopathological changes in livers versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - organ/system effects | 4 weeks | Dietary | Toxicity Factor Datasets |
SELENOMETHIONINE | decreased @ 60 ppm (regardless of methionine suppl. or protein levels) | body, liver and spleen weights, and tarsus length versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - whole animal | 4 weeks | Dietary | Toxicity Factor Datasets |
SELENOMETHIONINE | increased @ 15 (GSH-peroxidase only), 60 ppm Se, adequate protein | plasma GSH-peroxidase and alkaline phosphatase activities versus controls | Not Reported | Juvenile | 15/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 weeks | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENOMETHIONINE | no effect | distance run in 2 seconds from a fright stimulus vs controls | Not Reported | Chick | 32, 14, 14, 14, 11 in the 0, 1, 2, 4, and 8 ppm groups | 0, 1, 2, 4, or 8 ppm Se | TOX-Non-Repro-Sublethal - behavioral effects | 4 weeks (parents) | parental diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decreased | % normal hatchlings versus controls | Not Reported | Embryo | 492-518, 232-384, and 128-276 for the 0, 10, and 40 ppm DDE groups | 0, 10, or 40 ppm | TOX-REPRO - development | 2 years | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | decreased | number of 14-day old ducklings per hen versus controls | Both Male and Female | Hatchling | 274-327, 69-167, and 26-113 for the 0, 10, and 40 ppm DDE groups | 0, 10, or 40 ppm | TOX-REPRO - reproductive success | 2 years | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | increased | % cracked eggs versus controls | Female | Hatchling | 666-696, 620-664, and 317-602 for the 0, 10, and 40 ppm DDE groups | 0, 10, or 40 ppm | TOX-REPRO - physiology | 2 years | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | decreased | eggshell thickness versus controls | Female | Adult | 20-28, 21-25, and 10-23 for the 0, 10, and 40 ppm DDE groups | 0, 10, or 40 ppm | TOX-REPRO - physiology | 2 years | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Range | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CHLORPYRIFOS | 145 mg/kg | LD50 | 55.8 - 377 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
CHLORPYRIFOS | 29.4 mg/kg | LD50 | 18.6 - 46.7 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
CHLORPYRIFOS | 50.4 mg/kg | LD50 | 32.5 - 78.1 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
CHLORPYRIFOS | 83.3 mg/kg | LD50 | 44.0 - 158 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ENDOSULFAN | 27.8 mg/kg | LD50 | 22.8 - 33.8 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ENDOSULFAN | 6.47 mg/kg | LD50 | 5.19 - 8.05 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ENDOSULFAN | 7.89 mg/kg | LD50 | 5.77 - 10.8 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ENDOSULFAN | 34.4 mg/kg | LD50 | 26.1 - 45.3 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ALDICARB | 1.92 mg/kg | LD50 | 1.55 - 2.37 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ALDICARB | 3.60 mg/kg | LD50 | 2.90 - 4.49 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ALDICARB | 6.73 mg/kg | LD50 | 5.29 - 8.55 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
ALDICARB | 4.44 mg/kg | LD50 | 3.49 - 5.65 (95% CI) | Both Male and Female | Juvenile | 5 | NR | TOX-MORT - toxicity benchmarks | Single exposure | Gavage | Toxicity Factor Datasets |
Endpoint Value | Endpoint Description | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|
increased @ 15 , 60 ppm (regardless of methionine suppl. or protein levels) | liver GSH-peroxidase activity versus controls | 12/group | 0, 15, or 60 ppm Se; with and without added methionine, and varying protein levels | TOX-Non-Repro-Sublethal - organ/system effects | 4 weeks | Dietary | Toxicity Factor Datasets |