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Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
FENITROTHION | increase at 9 mg/l | Not Reported | Tadpole | 10/replicate; 3 replicates/dose | 1, 2, 5, 9 mg/l (nominal) | TOX-MORT - dose-response data | 24 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SULFURIC ACID | significant decrease at pH 3.5 and 4.0 | hatching success | Not Reported | 50 eggs/replicate, 6 replicates/group (n=294-312) | pH = 3.5, 4.0, 4.5, 5.0, 6.3 | TOX-REPRO - reproductive success | NR | waterborne | Toxicity Factor Datasets | |
SULFURIC ACID | significant increase at pH 3.5 and 4.0 | Not Reported | Tadpole | 120 animals/dose | pH = 3.5, 4.0, 4.5, 5.0, 6.3 | TOX-MORT - dose-response data | 3 wk | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
PARATHION | no effect | Not Reported | Tadpole | 30 animals/dose | 0, 1 mg/l (nominal) | TOX-MORT - dose-response data | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 99 ug/l (95% CL: 71-116 ug/l) | LC50 | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
ENDRIN | 2 ug/l (95% CL: 1-5 ug/l) | LC50 | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | 312 ug/l (95% CL: 225-435 ug/l) | EC50; Loss of equilibrium | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-REPRO - behavior | 96 hr | waterborne | Toxicity Factor Datasets |
ENDRIN | > 40 ug/l | EC50; Loss of equilibrium | Not Reported | Tadpole | 220 animals | 6 unspecified concentrations | TOX-REPRO - behavior | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PERMETHRIN | 7,033 ug/l (95% CL: 4,129-8,735 ug/l) | LC50 | Not Reported | Tadpole | 10 animals/replicate; 4 replicates/dose | NR | TOX-MORT - toxicity benchmarks | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CHLORDANE | no effect | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
CHLORDANE | increase at 0.5 lb/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
ENDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
DIELDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
ALDRIN | increase at 0.1 and 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
TOXAPHENE (POLYCHLORINATED CAMPHENES) | increase at 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
LINDANE | increase at 0.5 lbs/acre | Not Reported | Tadpole | ponds, southern San Joaquin Valley | 10 animals/dose | 0.1, 0.5 lbs/acre | TOX-MORT - mortality in the field | single application | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | increased @ 1-80 mg/kg | thymus weight to bw ratio | Female | Adult | 12/dose | 0, 1, 10, 20, 40, 80 mg/kg bw/d | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | Diet | Toxicity Factor Datasets |
GLYPHOSATE | increase@ 80 mg/kg bw/d | white blood cell count | Female | Adult | 12/dose | 0, 1, 10, 20, 40, 80 mg/kg bw/d | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 28 d | Diet | Toxicity Factor Datasets |
GLYPHOSATE | increase @ 80 mg/kg bw/d | plaque forming cell count/g spleen | Female | Adult | 12/dose | 0, 1, 10, 20, 40, 80 mg/kg bw/d | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 28 d | Diet | Toxicity Factor Datasets |
GLYPHOSATE | no effect | reciprocal of hemolysin titer (against sheep rbc) | Female | Adult | 12/dose | 0, 1, 10, 20, 40, 80 mg/kg bw/d | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 28 d | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARATHION | 25% at 4.6 ppm | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-MORT - dose-response data | up to 24 hr | diet | Toxicity Factor Datasets | |
PARATHION | 47% decrease at 4.6 ppm | mean brain cholinesterase activity relative to control | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | up to 24 hr | diet | Toxicity Factor Datasets |
PARATHION | 56% decrease at 4.6 ppm | mean plasma cholinesterase activity relative to control | Not Reported | Adult | 4/group | <0.05, 0.08, 4.6 ppm | TOX-EXP IND - biomarkers | up to 24 hr | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 31% decrease at 625 mg/kg bw 14% decrease at 125 mg/kg bw | hematocrit | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | 48% decrease at 625 mg/kg bw 27% decrease at 125 mg/kg bw 12% decrease at 25 mg/kg bw | red blood cell hemoglobin content | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at all doses (45-59%) | red blood cell delta aminolevulinic acid dehydratase | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | 30% decrease at 625 mg/kg bw 25% decrease at 125 mg/kg bw | plasma creatine phosphokinase | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (47-57%) | brain delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (71-79%) | kidney delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw (20-25%) | liver delta aminolevulinic acid dehydratase activity | Both Male and Female | Nestling | 10/group | 0,25,125,625 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 40% at 625 mg/kg bw | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-MORT - dose-response data | 10 d | gavage | Toxicity Factor Datasets | |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | body weight at end of dosing relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | decrease at 125, 625 mg/kg bw | growth rate relative to control | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-Non-Repro-Sublethal - organ/system effects | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at all doses 1.4, 3.5, 5.5 ppm at 25, 125, 625 mg/kg bw, respectively | liver lead concentration | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
LEAD (elemental) | increase at 125, 625 mg/kg bw 7.2, 15.5 ppm at 125, 625 mg/kg bw, respectively | kidney lead concentrations | Both Male and Female | Nestling | 10/group | 0,25,125,325 mg/kg bw | TOX-EXP IND - accumulation | 10 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | decrease at 10, 50 ppm | mean blood delta aminolevulinic acid dehydratase | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-EXP IND - biomarkers | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean packed cell volume and red blood cell hemoglobin | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | increase at 50 ppm 1.3 ppm (1.00 SD) males; 2.4 ppm (1.40 SD) females | mean lead concentration in liver | Both Male and Female | Adult | 16 pairs/group | 0, 10, 50 ppm | TOX-EXP IND - accumulation | 5-7 mo | diet | Toxicity Factor Datasets |
LEAD (elemental) | no effect | mean organ and carcass weights | Both Male and Female | Adult | 16 pairs/dose | 0, 10, 50 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 5-7 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 1.13 ppm blood at 212 ppm; 1.69 ppm blood at 448 ppm | mean lead concentration in blood | Both Male and Female | Adult | 8-14/group | 0.5, 120, 212, 448 ppm (dry wt) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |