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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | increased with all doses | brain, liver, and adipose dieldrin concentrations | Both Male and Female | Juvenile | 4-6 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-EXP IND - accumulation | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | no effect | bw versus controls | Both Male and Female | Juvenile | 9-25 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - organ/system effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | increased @ 10 ppm (liver only), 30 ppm (brain only) | brain and liver weight to body weight ratios versus controls | Both Male and Female | Juvenile | 9-25 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - organ/system effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | increased@ 4, 10, 30 ppm | hepatic microsomal enzyme activity versus controls | Both Male and Female | Juvenile | 5-15 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | increased @ 30 ppm | liver protein concentration versus controls | Both Male and Female | Juvenile | 5-15 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | increased @ 10, 30 ppm | liver DNA content versus controls | Male | Both Adults and Juveniles | 5-15 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - cellular/biochemical effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
DIELDRIN | decreased @ all doses | % drake encounter scores | Male | Both Adults and Juveniles | 30 per group | 0, 4, 10, and 30 ppm Dieldrin | TOX-Non-Repro-Sublethal - behavioral effects | Second - generation. Exposed 75 days after hatch. | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDT (4,4'-) | decreased | eggshell thickness versus controls | Female | Adult | 5 hens; 19 eggs | 0, 50 ppm | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
DDT (4,4'-) | decreased | eggshell weight versus controls | Female | Adult | 5 hens; 19 eggs | 0, 50 ppm | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
DDT (4,4'-) | decreased | eggshell quality (R-value) versus controls | Female | Adult | 5 hens; 19 eggs | 0, 50 ppm | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
DDT (4,4'-) | no effect | calcium concentration in eggshell versus controls | Female | Adult | 5 hens; 19 eggs | 0, or 50 ppm DDT | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
DDT (4,4'-) | no effect | total Ca/eggshell | Female | Adult | 5 hens; 19 eggs | 0, or 50 ppm | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
DDT (4,4'-) | no effect | Ca - ATPase activity in eggshell glands versus controls | Female | Adult | 5 hens; 19 eggs | 0, or 50 ppm | TOX-REPRO - physiology | 6 months | Diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | 79.5 | in loco heart rate | Not Reported | Tadpole | NR | 36 | 10 µg/L | TOX-MORT - dose-response data | 48 h | Toxicity Factor Datasets | |
PENOXSULAM | 7.52 mg/L | LC50 | Not Reported | Tadpole | Experimental Frog Farm, São Paulo | 6 | (+ vegetable oil adjuvant): 2.88 + 55.80; 4.32 + 83.70; 5.76 + 111.60; 7.20 mg/L C 139.50; 8.64 + 167.40 | TOX-MORT - toxicity benchmarks | 96 hr | Waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CARBOFURAN | 29.90 mg/L | LC50 | NR | Tadpole | Experimental Frog Farm, São Paulo | 6 | 0.20, 1.00, 5.00, 25.00, 125.00 mg/L | TOX-MORT - toxicity benchmarks | 96 hr | Waterborne | Toxicity Factor Datasets |
COPPER (elemental) | LC50 | Lab | 126 | 0, 0.75, 1.50, 2, 3, 4, 6, 8, 10, 12 mg Cu+/L | TOX-MORT - toxicity benchmarks | 48 h | Waterborne | Toxicity Factor Datasets | |||
COPPER (elemental) | LC50 | Lab | 126 | 0, 0.75, 1.50, 2, 3, 4, 6, 8, 10, 12 mg Cu+/L | TOX-MORT - toxicity benchmarks | 72 h | Waterborne | Toxicity Factor Datasets | |||
COPPER (elemental) | LC50 | Lab | 126 | 0, 0.75, 1.50, 2, 3, 4, 6, 8, 10, 12 mg Cu+/L | TOX-MORT - toxicity benchmarks | 96 h | Waterborne | Toxicity Factor Datasets | |||
FORMALDEHYDE | 10.53 mg/L | LC50 | NR | Tadpole | Fisheries Institute, APTA/SAA, São Paulo | 12 per treatment | 0, 6, 9, 12, 15, 18 mg/L | TOX-MORT - toxicity benchmarks | 96 h | Waterborne | Toxicity Factor Datasets |
LIDOCAINE | See citation Figure 2 | Heart rate | NR | Adult | 10 | 50 mg/kg (20 mg/mL) | TOX-Non-Repro-Sublethal - whole animal | 300 min | Subcutaneous injection | Toxicity Factor Datasets | |
LIDOCAINE | See citation Figure 1 | Reflexes | NR | Adult | 10 | 50 mg/kg (20 mg/mL) | TOX-Non-Repro-Sublethal - whole animal | 300 min | Subcutaneous injection | Toxicity Factor Datasets | |
LIDOCAINE | 59 ± 15 breaths/min | Reduced gular respiratory rate | NR | Adult | 10 | 50 mg/kg (20 mg/mL) | TOX-Non-Repro-Sublethal - whole animal | 300 min | Subcutaneous injection | Toxicity Factor Datasets | |
LIDOCAINE | See citation Figure 3 | Heart rate | NR | Adult | 6 | 50 mg/kg (20 mg/mL) | TOX-Non-Repro-Sublethal - whole animal | 160 min | Subcutaneous injection following sedation, surgery, recovery | Toxicity Factor Datasets | |
DIPHACINONE | 0.651 | % metabolism by liver microsome | F | Not Reported | Castroville, CA | 11 | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | Environmental | Toxicity Factor Datasets |
CHLOROPHACINONE | 0.148 | % metabolism by liver microsome | M | Not Reported | Castroville, CA | 14 | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | Environmental | Toxicity Factor Datasets |
CHLOROPHACINONE | 0.289 | % metabolism by liver microsome | F | Not Reported | Castroville, CA | 11 | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | Environmental | Toxicity Factor Datasets |
6 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 10 | 8.13 g (4.35 SD) food pellets w/0.03% cholecalciferol and 0.005% diphacinone | TOX-MORT - toxicity benchmarks | 10 d | Oral via food pellets | Toxicity Factor Datasets | |
6.5 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 10 | 7.07 g (3.56 SD) food pellets in 10 d w/0.03% cholecalciferol and 0.005% diphacinone | TOX-MORT - toxicity benchmarks | 10 d | Oral via food pellets | Toxicity Factor Datasets | |
4.5 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 5 | Artichoke bracts dipped in 30:1 canola oil: rodenticide mix (0.078 g/mL cholecalciferol and 0.013 g/mL diphacinone) | TOX-MORT - toxicity benchmarks | 10 d | Oral via coated artichoke bracts | Toxicity Factor Datasets | |
5.8 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 5 | Artichoke bracts dipped in 50:1 canola oil: rodenticide mix (0.078 g/mL cholecalciferol and 0.013 g/mL diphacinone) | TOX-MORT - toxicity benchmarks | 10 d | Oral via coated artichoke bracts | Toxicity Factor Datasets | |
5.4 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 5 | Artichoke bracts dipped in 60:1 canola oil: rodenticide mix (0.078 g/mL cholecalciferol and 0.013 g/mL diphacinone) | TOX-MORT - toxicity benchmarks | 10 d | Oral via coated artichoke bracts | Toxicity Factor Datasets | |
6.14 | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 10 | Artichoke bracts dipped in 60:1 canola oil: rodenticide mix (0.078 g/mL cholecalciferol and 0.013 g/mL diphacinone) | TOX-MORT - toxicity benchmarks | 10 d | Oral via coated artichoke bracts | Toxicity Factor Datasets | |
CHOLECALCIFEROL | No effect | Mean days to death | B | Not Reported | USDA National Wildlife Research Center, Fort Collins, CO | 5 | 2.44 g (0.81 SD) food pellets in 10 d w/0.075% cholecalciferol | TOX-MORT - toxicity benchmarks | 10 d | Oral via food pellets | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CYPERMETHRIN | Decreased | % survival | NR | Neonate | Oregon State University, Corvallis | 10 | 0.0, 1.0, 5.0 µg/L | TOX-MORT - toxicity benchmarks | 48 h | Waterborne | Toxicity Factor Datasets |
CYPERMETHRIN | Decreased | % survival | NR | Neonate | Oregon State University, Corvallis | 10 | 0.0, 1.0, 5.0 µg/L | TOX-MORT - toxicity benchmarks | 48 h | Waterborne | Toxicity Factor Datasets |
CYPERMETHRIN | 0.032 ± 0.005 SE | Embryo mass | NR | Embryo | Oregon State University, Corvallis | 10 | 0.0 µg/L | TOX-Non-Repro-Sublethal - whole animal | 48 h | Waterborne | Toxicity Factor Datasets |
CYPERMETHRIN | 0.028 ± 0.005 SE | Embryo mass | NR | Embryo | Oregon State University, Corvallis | 10 | 0.5 µg/L | TOX-Non-Repro-Sublethal - whole animal | 48 h | Waterborne | Toxicity Factor Datasets |
CYPERMETHRIN | 0.460 ± 0.009 SE | Mass | NR | Neonate | Oregon State University, Corvallis | 10 | 0.0 µg/L | TOX-Non-Repro-Sublethal - whole animal | 48 h | Waterborne | Toxicity Factor Datasets |
CYPERMETHRIN | 0.457 ± 0.040 SE | Mass | NR | Neonate | Oregon State University, Corvallis | 10 | 0.5 µg/L | TOX-Non-Repro-Sublethal - whole animal | 48 h | Waterborne | Toxicity Factor Datasets |