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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 3% | plasma corticosterone concentration, compared to control | Male | Juvenile | 24/dose | control, 3% (3 ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1 wk | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 3% | body weight | Male | Juvenile | Not Reported | control, 0.5, 1, 3% ( ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - whole animal | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 1 and 3% | daily food intake rate | Male | Juvenile | Not Reported | control, 0.5, 1, 3% ( ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - whole animal | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 0.5, 1, 3% | plasma corticosterone concentration, compared to control | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3-9 d | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease @ 0.5% | plasma corticosterone concentration, compared to control | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 50 d | diet | Toxicity Factor Datasets |
CRUDE OILS | increase @ 0.5, 1, 3% | hepatic microsomal naphthalene metabolism (nmol/min/mg protein) | Male | Juvenile | Not Reported | control, 0.5, 1, 3% (ml South Louisiana crude oil/ 100 g dry food) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 50 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID | decrease @ 1600 ppm | growth rate measured as changes in body weight, compared to control | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 1600 ppm | hematocrit and hemoglobin concentration, compared to controls | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 100, 400, 1600 ppm | plasma triglyceride concentration (21-42% increase, compared to controls) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 1600 ppm | plasma calcium concentration (6-10% greater than controls) and brain acetylcholinestrase activity (umol/min/g) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | 2 ug/g @ control; 4 ug/g @ 100 ppm; 5 ug/g @ 400 ppm; 51 ug/g @ 1600 ppm | boron accumulation in brain (geometric mean; ug/g dry weight) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 400 and 1600 ppm | brain ATP (nmol/g) and protein (mg/g) concentrations | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
BORIC ACID | 1 ug/g @ controls; 3 ug/g @ 100 ppm; 3 ug/g @ 400 ppm; 29 ug/g @ 1600 ppm | liver boron concentration (geometric mean; ug/g dry weight) | Both Male and Female | Juvenile | 10 animals/pen; 3 pens/dose | control, 100, 400, 1600 ppm B as boric acid | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BORIC ACID | decrease @ 1000 ppm | % hatching success in fertile eggs and productivity per female (mean # of 21 d old ducklings) | Both Male and Female | Adult | 15/sex/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - reproductive success | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | no effect | eggshell thickness and Ratcliffe index of eggshell quality | Female | Adult | 15/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - physiology | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | increase @ 1000 ppm | % embryo mortality (day 15 to hatch) and duckling mortality (hatch to day 7) | Both Male and Female | Both Adults and Juveniles | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - development | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 300, 1000 ppm | body weight of hatchlings, compared to controls | Both Male and Female | Hatchling | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-REPRO - development | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | decrease @ 30, 300, 1000 ppm | hatchling weight gain over 21 d, compared to controls | Both Male and Female | Hatchling | 11-23/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-Non-Repro-Sublethal - whole animal | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | Egg; 3 ug/g @ 30 ppm, 13 ug/g @ 300 ppm, 49 ug/g @ 1000 ppm: Liver; 15 ug/g @ 300 ppm, 33 ug/g @ 1000 ppm: Brain; 14 ug/g @ 300 ppm, 41 ug/g @ 1000 ppm | boron concentrations in adult tissues (geometric mean; ug/g dry weight). | Both Male and Female | Adult | 10-20/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-EXP IND - accumulation | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
BORIC ACID | Liver; 3 ug/g @ 30 ppm, 17 ug/g @ 300 ppm, 51 ug/g @ 1000 ppm: Brain; 4 ug/g @ 30 ppm, 19 ug/g @ 300 ppm, 66 ug/g @ 1000 ppm | boron concentrations in ducklings 21 d of age (geometric mean; ug/g dry weight). Concentrations at other doses were not detected. | Both Male and Female | Juvenile | 10-13/dose | control, 30, 300, 1000 ppm B as boric acid (dry wt basis) | TOX-EXP IND - accumulation | 3 wks (pre-breeding) + breeding period to 21 d post-hatch | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | % mortality, compared to controls | Male | Adult | 5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg South Louisiana crude oil, daily | TOX-MORT - dose-response data | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | no effect | body weight, gross lesions or signs of clinical illness, compared to controls | Male | Adult | 5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg South Louisiana crude oil, daily | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | no effect | body weight and gross lesion incidence, compared to controls | Male | Adult | 4-5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | decrease @ 4.0, 7.0, 12.0 ml/kg/d | mean spleen index (spleen wt./body wt.) | Male | Adult | 4-5/dose | control, 1.0, 2.5, 4.0, 7.0, 12.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
COREXIT 9527 | no effect | % mortality, compared to controls | Male | Adult | 6/dose | control, 0.006, 0.012, 0.025, 0.05 ml/kg, daily; diluted in water | TOX-MORT - dose-response data | 28 d | gavage | Toxicity Factor Datasets |
COREXIT 9527 | no effect | body weight, compared to controls | Male | Adult | 6/dose | control, 0.006, 0.012, 0.025, 0.05 ml/kg, daily; diluted in water | TOX-Non-Repro-Sublethal - whole animal | 28 d | gavage | Toxicity Factor Datasets |
FUEL OILS | increase @ 2.5, 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 9-32/dose | control, 2.5, 4.0 ml/kg Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS | increase @ 4.0 ml/kg | susceptibility to Pasturella multocida estimated as % mortality 2-wks post-exposure to Pasturella multocida which was given on day 28 | Male | Adult | 10-32/dose | control, 2.5, 4.0 ml/kg South Louisiana crude oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
CRUDE OILS, FUEL OILS | no effect | antibody-mediated immunity estimated by direct spleen plaque-forming cell assays (PFCs/g spleen); mallards inoculated with sheep red blood cells on day 24 | Male | Adult | 9/dose | control, 4.0 ml/kg South Louisiana crude oil or Bunker C fuel oil, daily | TOX-Non-Repro-Sublethal - organ/system effects | 28 d | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | body weight | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - whole animal | 9 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | increase | plasma triglyceride and sodium concentrations, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease | hematocrit and plasma cholesterol concentration, compared to control (based on treatment means at 3, 6, 9 wks) | Not Reported | Juvenile | 25/dose | control, 0.15% Prudhoe Bay crude oil | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
COREXIT 9527 | no effect | body weight | Not Reported | Juvenile | 25/dose | control, 0.015% | TOX-Non-Repro-Sublethal - whole animal | 9 wks | diet | Toxicity Factor Datasets |
COREXIT 9527 | increase | plasma alanine aminotransferase activity, compared to control | Not Reported | Juvenile | 25/dose | control, 0.015% | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 9 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FUEL OILS | decrease @ 5, 10, 20, 50 ul | 6-day % survival of mallard embryos from eggs treated on the 8th day of incubation | Not Reported | Embryo | 50/dose | control, 5, 10, 20, 50 ul Bunker C fuel oil, applied externally to the air cell of viable eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
FUEL OILS | decrease @ 5, 10, 20, 50 ul | 30-d % hatching success | Not Reported | Embryo | 50/dose | control, 5, 10, 20, 50 ul Bunker C fuel oil, applied externally to the air cell of viable eggs | TOX-REPRO - reproductive success | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | decrease @ 1, 5, 10 ul | 18-d % survival, mean embryonic weight, crown-rump length (5ul) and bill length | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
CRUDE OILS | increase @ 1, 5 ul | % abnormal survivors, compared to controls | Both Male and Female | Embryo | 50/dose | control, 1, 5, 10 ul South Louisiana crude oil applied externally to eggs | TOX-REPRO - development | single | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | no effect | onset of laying, egg production, egg fertility, compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - physiology | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |
CRUDE OILS | decrease | egg hatchability (# eggs hatching/# fertile eggs), compared to controls | Female | Adult | 20 hens/dose | control, 0.5% (w/w) South Louisiana crude oil | TOX-REPRO - reproductive success | pre-breeding period (19 Feb. - 5 Apr., 1980) + breeding period to hatch | diet | Toxicity Factor Datasets |