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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | increased to 61% @ 1000 (LL), 100% @ 5000 (LL) | mortality versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased @ 1000 (LL) | food consumption versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - behavioral effects | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | see table | Ca, Al, P concentrations in femur for different treatments after 2 and 10 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased on LL and LH diets | femur mass and mean breaking force (LL, LH vs. NN diets) after 2 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased with LL and LH diets | femur breaking strength (LL,LH vs. NN diets) after 10 wks of treatment | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | increased in LL diets | incidence of clinical signs (LL vs. LH vs. NN diets) | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
STEEL COMPOUNDS, TRIBUTYLTIN | increased in both groups (no treatment diffs) | white blood cell counts, monocyte counts, total protein concentrations over study period | Both Male and Female | Juvenile | 20/group | three #4 steel shot or three #4 tributyltin shot implants | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1-8 wks | intramuscular | Toxicity Factor Datasets |
STEEL COMPOUNDS, TRIBUTYLTIN | increased with steel shot, wk 8 | overall response score (inflammation, muscle damage changes) | Both Male and Female | Juvenile | 20/group | three #4 steel shot or three #4 tributyltin shot implants | TOX-Non-Repro-Sublethal - whole animal | 1-8 wks | intramuscular | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 200, 800 ppm | food consumption compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | body wt, liver wt:brain wt, kidney wt:brain wt, duodenal wt compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - whole animal | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | plasma biochemistry compared to controls | Male | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effects | reproductive success (number of eggs laid, hatchability, duckling survival) compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-REPRO - reproductive success | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | increased @ 12.5, 50, 200, 800 ppm diet | kidney, blood, liver, and feather concentrations of Ni compared to controls | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-EXP IND - accumulation | 90 d | diet | Toxicity Factor Datasets |
NICKEL SULFATE | 1.94 (kidney), 0.52 (liver), 0.139 (blood), 68.06 (feathers) ppm, wet wt | mean tissue concentrations @ 800 ppm Ni in diet | Both Male and Female | Adult | 6 pairs/group | 0,12.5,50,200,800 ppm diet | TOX-EXP IND - accumulation | 90 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
NICKEL SULFATE | increased @ 800, 1200 ppm | incidence of clinical signs and mortality | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-MORT - dose-response data | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ 1200 ppm | body wt by 28 d of age | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effect | bill length | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ 1200 pmm (30 d of age) | weight:length of humerus | Male | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | decreased @ all doses (by 60 d of age) | weight:length of humerus | Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | no effect | organ wt:body wt ratios | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-Non-Repro-Sublethal - whole animal | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
NICKEL SULFATE | 1.0-22.7 (liver), 2.7-74.4 (kidney) ppm, wet wt | Ni concentrations (ranges) in liver and kidney in ducklings that died @ 1200 ppm | Both Male and Female | Juvenile | 36 birds/dose | 0,200,800,1200 ppm in diet | TOX-EXP IND - accumulation | 30, 60, 90 d of age | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | no effect | mortality versus controls | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-MORT - dose-response data | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | no effect | body wt, hematocrit, hemoglobin, food consumption versus controls | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - whole animal | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 2.116 (@ 2 ppm), 19.510 (@ 20 ppm), 96.600 9@ 200 ppm) ppm, wet wt | mean Cd concentrations in liver after 90 d of treatment | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm diet | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 4.627 (@ 2 ppm), 54.333 (@ 20 ppm), 77.222 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in kidneys after 90 d of treatment | Both Male and Female | Adult | 20 pairs/group | 0,20,200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased to 0.010 (@ 20 ppm), 0.040 (@ 200 ppm) ppm, wet wt | Cd concentrations in eggs versus controls | Both Male and Female | Adult | 15 eggs (20 ppm), 3 eggs (200 ppm) | 0,20,200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm/60 or 90 d of treatment, 30 d post-treatment | mean kidney weight versus controls | Both Male and Female | Adult | 10 kidneys/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | decreased @ all doses/30 d post-treatment, and 200 ppm/90 d of treatment | mean testis weight versus controls | Male | Adult | 5 testes/group | 0,20,200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 days of treatment | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SALINE WATER | decreased @ 4000 or 7720 umhos/cm | body weight by day 14 or 16 versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control), less saline water (3750-7490 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 28 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased | plasma protein levels; serum osmolality; salt, kidney and adrenal gland size versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control), less saline water (3750-7490 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 14-28 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased @ 67,000 umhos/cm (100%), 35,000 umhos/cm (100%), 21,500 umhos/cm (78%), and 20,000 umhos/cm (60%) | mortality versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-MORT - dose-response data | 14 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | increased @ 20,000 umhos/cm and above | thymus size versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - organ/system effects | 14 d | drinking water | Toxicity Factor Datasets |
SALINE WATER | decreased @ 20,000 and 21,500 umhos/cm | body weight by day 14 versus controls | Not Reported | Juvenile | 10 birds/group | tap water (control),more saline water (20,000-67,000 umhos/cm); see citation for individual ion concentrations | TOX-Non-Repro-Sublethal - whole animal | 14 d | drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | increased @ 0.5, 3 ppm | changes in approach behavior (maternal call stimulus) | Not Reported | Juvenile | 249 (control); 276 (0.5 ppm); 108 (3 ppm) | 0,0.5,3 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | incubation period | parental diet (in ovo) | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | increased @ 0.5, 3 ppm | changes in avoidance behavior (frightening stimulus) | Not Reported | Juvenile | 319 (control); 339 (0.5 ppm); 158 (3 ppm) | 0,0.5,3 ppm diet | TOX-Non-Repro-Sublethal - behavioral effects | incubation period | parental diet (in ovo) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | mean egg weight compared to controls | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | 1 (@ 0.5 ppm), 6.46-9.19 (@ 3 ppm) ppm in eggs | mercury concentrations in eggs (at plateau) | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | decreased @ 0.5, 3 ppm | duration of egg production compared to controls | Female | Adult | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - physiology | NR | diet | Toxicity Factor Datasets |
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | hatching success and 1 wk survival of hatchlings compared to controls | Not Reported | Juvenile | 10 females, 3 males/dose | 0, 0.5, 3 ppm diet | TOX-REPRO - reproductive success | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLMERCURY DICYANDIAMIDE | decreased @ 3 ppm | duckling survival | Not Reported | Juvenile | Not Reported | 0, 0.5, 3 ppm diet | TOX-REPRO - reproductive success | 3-15 mos | parental diet | Toxicity Factor Datasets |