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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decreased @ 500, 1000, 5000 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 500, 1000, 5000 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
AROCLOR 1254 | decreased @ 1000 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 1000 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
CHLOROETHYLMERCURY | decreased @ 500 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 500 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
DICHLOROPHENOXY-ACETIC ACID (2,4-) | decreased @ 1500 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 1500 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
HEPTACHLOR | decreased @ 1000 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 1000 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
ARSENITE, SODIUM | decreased @ 100 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | 0, 100 mg/kg bw | TOX-REPRO - physiology | single | intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), LEAD COMPOUNDS, MERCURY COMPOUNDS | decreased @ 40 ppm DDE | eggshell thickness versus controls | Female | Adult | 10/group | 0, 40 ppm DDE, 100 ppm lead, or 200 ppm N-(ethylmercury)-p-toluene sulfoanilide | TOX-REPRO - physiology | 55 d - approx. 2 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-), LEAD COMPOUNDS, MERCURY COMPOUNDS | decreased with both treatments | eggshell thickness versus controls | Female | Adult | 10/group | 0, 40 ppm DDE + 100 ppm lead, or 40 ppm DDE + 200 ppm N-(ethylmercury)-p-toluene sulfoanilide | TOX-REPRO - physiology | 55 d - approx. 2 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 78.2 (carcass); 61.6 (egg); 4.1 (brain) ppm, wet wt | DDE residues in whole carcass, egg contents, and brain | Female | Adult | 10/group | 40 ppm DDE | TOX-EXP IND - accumulation | approx. 2 mos. | diet | Toxicity Factor Datasets |
MERCURY COMPOUNDS | 2.5 (carcass); 1.25 (egg); 23.7 (kidney) ppm, wet wt | mercury residues in whole carcass, egg contents, and kidneys | Female | Adult | 10/group | 200 ppm N-(ethylmercury)-p-toluene sulfoanilide | TOX-EXP IND - accumulation | 55 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 3.7 (carcass); 2.5 (egg); 2.5 (eggshells); 9.6 (bone) ppm, wet wt @ 100 ppm lead; 3.4 (carcass); 0.88 (egg); 2.8 (eggshells); 35.0 (bone) ppm, wet wt @ 100 ppm lead + DDE | lead residues in whole carcass, egg contents, eggshells, and bone | Female | Adult | 10/group | 100 ppm lead, or 40 ppm DDE + 100 ppm lead | TOX-EXP IND - accumulation | approx. 2 mos | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | 0.822 (0.059-21.60) ppm wet wt | geometric mean liver concentration (range) | Not Reported | Not Reported | Ebro Delta Natural Park | 39 birds | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
LEAD COMPOUNDS | 1.367 (<0.05-29.80) | geometric mean concentration in kidneys (range) | Not Reported | Not Reported | Ebro Delta Natural Park | 39 birds | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
LEAD COMPOUNDS | humerus, 41.652 (8.20-211.6); spleen, 0.669 (0.128-2.397); pancreas, 3.295 (1.074-13.47); brain, 1.367 (0.120-117.1) | geometric mean concentrations (ranges) in humerus, spleen, pancreas, and brain | Not Reported | Not Reported | Ebro Delta Natural Park | 6-10 birds/tissue type | 297,590 shot pellets/ha (in sediment) | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE, LEAD CHLORIDE | 7.2 (0.9) ug Pb/g @ 100 ppm Pb; 104.8 (19.1) ug Pb/g @ 100 ppm Cd; 54.2 (3.7) ug Cd/g @ 50 ppm Cd + 50 ppm Pb (dry wt) | mean (SE) concentrations in liver | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, LEAD CHLORIDE | 67.8 (12.4) @ 10 ppm Cd; 371.8 (22.3) @ 100 ppm Cd; 3.4 (0.6) @ 100 ppm Pb; 201.0 (26.9) @ 50 ppm Cd + 50 ppm Pb (ug/g, dry wt) | mean (SE) Cd concentrations in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, LEAD CHLORIDE | 4.1 (0.5) @ 10 ppm Pb; 22.5 (1.5) @ 100 ppm Pb; 3.1 (0.3) @ 5 ppm Cd + 5 ppm Pb; 16.1 (1.4) @ 50 ppm Cd+ 50 ppm Pb (ug/g, dry wt) | mean (SE) Pb concentrations in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, COPPER COMPOUNDS, LEAD CHLORIDE | 56.7(7.7) @ 100 ppm Cd; 37.7 (3.7) @ 50 ppm Cd + 50 ppm Pb (ug/g, dry wt) | mean (SE) Cu concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE, LEAD CHLORIDE, ZINC COMPOUNDS | 99 (6) @ 110 ppm Cd; 125 (7) @ 100 ppm Cd; 100 (5) @ 5 ppm Cd + 5 ppm Pb; 112 (2) @ 50 ppm Cd + 50 ppm Pb | mean (SE) Zn concentrations (ug/g, dry wt) in kidney | Male | Juvenile | 6-8 birds/dose | 0, 10 ppm Cd, 100 ppm Cd, 10 ppm Pb, 100 ppm Pb, 5 ppm Cd +5 ppm Pb, 50 ppm Cd + 50 ppm Pb | TOX-EXP IND - accumulation | 42 +/- 1 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM CHLORIDE | increased @ 200 ppm | weight of kidneys versus controls | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | decreased @ 200 ppm | weight of testes versus controls | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm | incidence of kidney lesions versus controls | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | increased @ 200 ppm | incidence of testes alterations (atrophy, decreased spermatogenesis) versus controls | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 0.46 (@ 0 ppm), 4.63 (@ 2 ppm), 54.33 (@ 20 ppm), 77.22 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in kidneys (ppm, wet wt) by 90 days | Both Male and Female | Adult | 10 birds | 0, 2, 20, 200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
CADMIUM CHLORIDE | 0.03 (@ 0 ppm), 0.02 (@ 2 ppm), 0.72 (@ 20 ppm) 8.47 (@ 200 ppm) ppm, wet wt | mean Cd concentrations in testes (ppm, wet wt) by 90 days | Male | Adult | 5 birds | 0, 2, 20, 200 ppm | TOX-EXP IND - accumulation | 30, 60, or 90 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM, SELENOMETHIONINE | increased (40%) @ 60 ppm Se | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | incidence of ducklings with histopathological lesions versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | decreased @ 60 ppm Se, 200 ppm As | growth rate of body weight versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with or 22% protein in diet) | TOX-Non-Repro-Sublethal - whole animal | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased @ 60 ppm Se | glutathione peroxidase activity versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 22% protein in diet) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 4 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM, SELENOMETHIONINE | increased (100%) @ 60 ppm Se and (53%) @ 200 ppm As | incidence of mortality versus controls | Not Reported | Juvenile | 15 birds/group | 0, 15 ppm Se, 60 ppm Se, 200 ppm As, 15 ppm Se + 200 ppm As, 50 ppm Se + 200 ppm As (each dose combined with 7% protein in diet) | TOX-MORT - dose-response data | 4 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ARSENATE, SODIUM | no effect | survival rate versus controls | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-MORT - dose-response data | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | decreased @ 30, 100, 300 ppm | growth rate versus controls | Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | decreased @ 300 ppm | growth rate versus controls | Male | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | no effect | incidence of histopathological lesions, and liver, brain, and spleen weights | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - organ/system effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 300 ppm | plasma biochemistry changes versus controls | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 10, 100, 300 ppm | plasma concentration of triglycerides | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 10, 100, 300 ppm | incidence of altered brain and liver biochemistry | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 10 wks | diet | Toxicity Factor Datasets |
ARSENATE, SODIUM | increased @ 100 ppm ( 0.3 ppm, dry wt), 300 ppm (1.3 ppm, dry wt) | arsenic concentrations in liver (geometric means in parentheses) | Both Male and Female | Juvenile | 30 birds/group | 0, 30, 100, 300 ppm | TOX-EXP IND - accumulation | 10 wks | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
ALUMINUM SULFATE | decreased @ 1000 ppm Al (LH, LL), 5000 ppm Al (NN) | body weight growth versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |
ALUMINUM SULFATE | decreased @ 1000 (LL), 1000 (LH), 5000 ppm (LH) | growth of body components (tarsus, culmen) versus controls | Not Reported | Juvenile | 12-14/group | 0, 200, 1000, 5000 mg Al/kg diet, combined with low Ca:low P (LL), normal Ca:normal P (NN), or low Ca:high P (LH) | TOX-Non-Repro-Sublethal - whole animal | 10 wks | diet | Toxicity Factor Datasets |