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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | no effect | number of litters per 100 breeding females, measured by observing litters in nesting boxes at a control and roadside site | Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 50 nesting boxes, 66 observation periods nimals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
LEAD COMPOUNDS | significant increase | mortality during winter, estimated by number of mice recaptured the following breeding season at a control and roadside site | Both Male and Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 98 - 180 tagged animals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-MORT - mortality in the field | NR | multiple | Toxicity Factor Datasets |
LEAD ACETATE | increase at 0.5 and 1% diet | incidence of acid-fast staining intranuclear inclusion bodies within kidney proximal convoluted tubule cells | Both Male and Female | Adult | 5 breeding pairs/dose | 0, 0.1, 0.5, 1.0% | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 26 wk | diet | Toxicity Factor Datasets | |
LEAD ACETATE | no effect | litter mortality | Both Male and Female | Adult | 5 breeding pairs | 0, 0.1, 0.5, 1.0% | TOX-REPRO - reproductive success | 26 wk | diet | Toxicity Factor Datasets | |
LEAD ACETATE | no effect | incidence of congenital malformations | Both Male and Female | Juvenile | 5 breeding pairs/dose | 0, 0.1, 0.5, 1.0% | TOX-REPRO - development | 26 wk | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | 48 mg/kg bw (95% CL: 39-74 mg/kg, slope = 2.57 +/- 0.73SE) | LD50 | Male | Adult | 5-7 animals/dose | 0, 20, 25, 32, 40, 50, 63, 79 mg/kg body weight | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 1180 ppm diet (95% CL: 709-1485, slope = 1.88 +/- 0.57SE) | LD50 | Both Male and Female | Adult | 10 animals/dose | 6 doses | TOX-MORT - toxicity benchmarks | 10 d | diet | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 2425 ppm diet (95% CL: 1856-3245, slope = 1.45 +/- 0.25SE) | LD50 | Both Male and Female | Adult | 10 animals/dose | 6 doses | TOX-MORT - toxicity benchmarks | 5 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
MERCURY COMPOUNDS | increase and decrease | decreased swimming ability, increased time for mouse to leave circle in center of field, decreased number of lines crossed and increased number of backward movements compared to a reference site | Male | Adult | Bird Island, Great Salt Lake | 7 - 14 animals | Mean hair concentration; 10.8 +/- 2.0 ppm | TOX-Non-Repro-Sublethal - behavioral effects | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, COPPER COMPOUNDS, ZINC COMPOUNDS | Diet:Soil; 128.0 (Cd), 1.31 (Cu), 1.87 (Zn). Liver:Soil; 35.3 (Cd), 0.17 (Cu), 1.25 (Zn). Liver:Diet; 0.27 (Cd), 0.12 (Cu), 0.66 (Zn). | Ratio of metal concentrations (ug/g dry weight) in diet:soil, liver:soil and liver:diet at an abandoned mine site. Diet concentrations measured from stomach contents. Soil based on acid extractable concentrations. Soil copper; liver cadmium, copper an | Both Male and Female | Adult | Blue Grouse Mountain Copper Mine, Honeymoon Bay, Vancouver Island, British Columbia | 6-9 soil or tissue samples/site | Soil: 0.21 +/- 0.006 SD (Cd), 315.0 +/- 3.15SD (Cu), 80.6 +/- 10.4SD (Zn) mg/kg dry weight | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | no effect | population density, compared to control site | Both Male and Female | Both Adults and Juveniles | Maple Ridge, British Columbia | 13 trapping periods | 0, 3.0 kg/ha | TOX-POP - size effects | up to 4 yr | field application | Toxicity Factor Datasets |
GLYPHOSATE | increase | % of trapped males and females in breeding condition, compared to control site | Both Male and Female | Adult | Maple Ridge, British Columbia | 24 - 62 animals | 0, 3.0 kg/ha | TOX-REPRO - physiology | up to 4 yr | field application | Toxicity Factor Datasets |
GLYPHOSATE | no effect | average duration of life during summer and winter periods | Both Male and Female | Adult | Maple Ridge, British Columbia | 2 - 40 animals | 0, 3.0 kg/ha | TOX-MORT - mortality in the field | up to 4 yr | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLCHLORANTHRENE (3-) | 0.14 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
METHYLCHLORANTHRENE (3-) | 1.24 mg/kg/d | ED50 for ethoxyresorufin-O-dealkylase (EROD) activity | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIBENZ[A]ANTHRACENE (1,2,5,6-) | 0.048 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIBENZ[A]ANTHRACENE (1,2,5,6-) | 0.85 mg/kg/d | ED50 for ethoxyresorufin-O-dealkylase (EROD) activity | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIMETHYLBENZ[A]ANTHRACENE (7,12-) | 0.026 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, LEAD COMPOUNDS, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS, SELENIUM COMPOUNDS | no effect | incidence of liver and kidney histopathologies was not related to contaminant concentrations | Not Reported | Not Reported | salt marsh, San Pablo and San Francisco Bays | 26 animals | Range of tissue means (ppm, dry wt.): Liver; 0.05-1.08 (mercury), 2.32-3.53 (selenium). Kidney; 0.4-2.11 (cadmium), 0.6-1.92 (lead). Carcass; 0.02-0.22 (PCBs). | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TRIFLUOROMETHYL-4-NITROPHENOL (3-, LAMPRECIDE) | 11.62 mg/kg bw (95% CL: 10.71-13.14) | LD50 | Not Reported | Tadpole | 5 | NR | TOX-MORT - toxicity benchmarks | single | intraperitoneal | Toxicity Factor Datasets |
TRIFLUOROMETHYL-4-NITROPHENOL (3-, LAMPRECIDE) | 15.35 mg/kg bw (95% CL: 8.72-21.98) | LD50 | Not Reported | Adult | 7 | NR | TOX-MORT - toxicity benchmarks | single | intraperitoneal | Toxicity Factor Datasets |
TRIFLUOROMETHYL-4-NITROPHENOL (3-, LAMPRECIDE) | 0.95 mg/l (95% CL: 0.72 - 1.14) | LC50 | Not Reported | Tadpole | 5 | NR | TOX-MORT - toxicity benchmarks | 24 hr | waterborne | Toxicity Factor Datasets |
TRIFLUOROMETHYL-4-NITROPHENOL (3-, LAMPRECIDE) | 12.99 mg/l (95% CL: 6.75 - 19.22) | LC50 | Not Reported | Adult | 7 | NR | TOX-MORT - toxicity benchmarks | 24 hr | waterborne | Toxicity Factor Datasets |
TRIFLUOROMETHYL-4-NITROPHENOL (3-, LAMPRECIDE) | effect observed at 1.0 - 3.0 mg/l | growth development arrested | Not Reported | Embryo | Not Reported | 0.1, 0.25, 0.5, 1.0, 2.0, 3.0 mg/l | TOX-REPRO - development | 96 hr | waterborne | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CARBOFURAN | decrease | proportion of pairs that raised at least one young (vs. untreated controls) | Both Male and Female | Adult | Saskatchewan | 13 pairs | standard application within 50 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
CARBARYL | no effect | proportion of pairs that raised at least one young (vs. untreated controls) | Both Male and Female | Adult | Saskatchewan | 30 pairs | standard application within 50 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
CARBOFURAN | decrease | maximum number of young observed per nest (vs. untreated controls) | Both Male and Female | Juvenile | Saskatchewan | 13 pairs | standard application within 50 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
CARBOFURAN | no effect | maximum number of young observed per nest (vs. untreated controls) | Both Male and Female | Juvenile | Saskatchewan | 30 pairs | standard application within 50 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
CARBARYL, CARBOFURAN | no effect | maximum number of young observed per nest (vs. untreated controls) | Both Male and Female | Juvenile | Saskatchewan | 18 pairs | standard application within 400 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
CARBARYL, CARBOFURAN | no effect | proportion of pairs that raised at least 1 young (vs. untreated controls) | Both Male and Female | Adult | Saskatchewan | 18 pairs | standard applications within 400 m of burrow | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
STRYCHNINE | no effect | proportion of pairs that raised at least 1 young | Both Male and Female | Adult | Saskatchewan | 27 pr | 2.5 mg/g dry bait application for ground squirrels | TOX-REPRO - reproductive success | NR | diet (secondary exposure) | Toxicity Factor Datasets |
STRYCHNINE | no effect | number of young produced per nest attempt | Both Male and Female | Juvenile | Saskatchewan | 27 pr | 2.5 mg/g dry bait application for ground squirrels | TOX-REPRO - reproductive success | NR | diet (secondary exposure) | Toxicity Factor Datasets |
STRYCHNINE | no effect | number of chicks produced per successful pair | Both Male and Female | Juvenile | Saskatchewan | 27 pr | 2.5 mg/g dry bait application for ground squirrels | TOX-REPRO - reproductive success | NR | diet (secondary exposure) | Toxicity Factor Datasets |
STRYCHNINE | no effect | chick mass index | Both Male and Female | Juvenile | Saskatchewan | 27 pr | 2.5 mg/g dry bait application for ground squirrels | TOX-REPRO - development | NR | diet (secondary exposure) | Toxicity Factor Datasets |
STRYCHNINE | decrease | adult body weight | Both Male and Female | Adult | Saskatchewan | 27 pr | 2.5 mg/g dry bait application for ground squirrels | TOX-Non-Repro-Sublethal - whole animal | NR | diet (secondary exposure) | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
HEPTACHLOR | no effect | mean clutch size | Female | Adult | Columbia Basin | 6 nests | 0.16-0.19 ppm (wet wt) | TOX-REPRO - reproductive success | NR | in ovo | Toxicity Factor Datasets |
HEPTACHLOR | no effect | eggshell thickness | Female | Adult | Columbia Basin | 6 nests | 0.16-0.19 ppm (wet wt) | TOX-REPRO - physiology | NR | in ovo | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 20.4% decrease | eggshell thickness versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-REPRO - physiology | 3 weeks | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | 17% decrease | serum calcium versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3 weeks | Diet | Toxicity Factor Datasets |
DDE (4,4'-) | no effect | serum calcium after PTH injection versus controls | Female | Adult | 6 hens; 45 total eggs | 0, 10 ppm | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 3 weeks | Diet | Toxicity Factor Datasets |