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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DICHLOROPHENOXY-ACETIC ACID (2,4-) | no effect | mean litter size, based upon number of viable embryos or placental scars | Female | Adult | Gunnison County and Saquache County, (elev., 8500 - 9300 ft.) | 66-77 animals | 0, 2-3 lbs/acre | TOX-REPRO - reproductive success | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
DIPHACINONE | increase at 0.0025% | Both Male and Female | Not Reported | 10 animals/dose | 0.00125, 0.0025, 0.005, 0.01, 0.02% | TOX-MORT - dose-response data | 2 d | diet | Toxicity Factor Datasets |
CHLOROPHACINONE | increase at 0.00125% | Both Male and Female | Not Reported | 10 animals/dose | 0.00125, 0.0025, 0.005, 0.01, 0.02% | TOX-MORT - dose-response data | 2 d | diet | Toxicity Factor Datasets |
DIPHACINONE | increase @ 0.00125- 0.02% | Both Male and Female | Not Reported | 10 animals/dose | 0.00125, 0.0025, 0.005, 0.01, 0.02% | TOX-MORT - dose-response data | 4 d | diet | Toxicity Factor Datasets |
CHLOROPHACINONE | increase @ 0.00125-0.02% | Both Male and Female | Not Reported | 10 animals/dose | 0.00125, 0.0025, 0.005, 0.01, 0.02% | TOX-MORT - dose-response data | 4 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
ARSENIC COMPOUNDS, CADMIUM COMPOUNDS, COPPER COMPOUNDS, LEAD COMPOUNDS, ZINC COMPOUNDS | Arsenic, <0.02; Cadmium, 0.08; Copper, 3.4; Lead, <0.003; Zinc, 29.5 ug/g | mean carcass concentration (ug/g wet wt.); mean deer mice body weight = 36.0 +/- 8.3SD, n=8 | Not Reported | Not Reported | Milltown Reservoir, Missoula | 8 animals | Mining waste; Mean soil concentrations (n=8): Arsenic, 52.5 +/- 6.2; Cadmium, 7.8 +/- 0.7; Copper, 532.2 +/- 69.4; Lead, 65.7 +/- 6.4; Zinc, 1,908.9 +/- 392.9SE ug/g | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | decrease @ 3.61 kg/ha | population density in enclosures with mowed alfalfa | Both Male and Female | Both Adults and Juveniles | Hyslop Crop Science Field Laboratory, Corvallis | 0-30 animals/enclosure; 4 enclosures/dose | 0, 0.88, 3.61 kg/ha | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | decrease at 5 mg/kg | homing orientation test, measured as time in maze pointing to capture site | Both Male and Female | Both Adults and Juveniles | NR | 15 animals/dose | 0, 5 mg/kg | TOX-Non-Repro-Sublethal - behavioral effects | single | intraperitoneal | Toxicity Factor Datasets |
DIELDRIN | decrease at 5 mg/kg | homing, measured as number recaptured at pre-exposure site | Both Male and Female | Both Adults and Juveniles | NR | 15 animals/dose | 0, 5 mg/kg | TOX-Non-Repro-Sublethal - behavioral effects | single | intraperitoneal | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 1.05 (0.05 SE) ppm (wet wt) | lead concentration in liver | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 0.70 (0.20 SE) ppm (wet wt) | lead concentration in tibia | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 232 (9 SE) ppm (wet wt) | DDE concentration in carcass | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | 10.4 (0.6 SE) ppm (wet wt) | DDE concentration in brain | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
DDE (4,4'-), DIELDRIN, LEAD COMPOUNDS | decreased | bw (versus pre-study bw) | Female | Juvenile | 2 | 38 lead, 48 DDE, 1.2 dieldrin ppm (wet wt) in voles | TOX-Non-Repro-Sublethal - whole animal | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LEAD (elemental) | 0.367 (0.129 SE) ppm at 49 mg/d | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 49 mg/d (lead shot) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD (elemental) | 28.70 (2.6 SE) ppm at 49 mg/d | mean lead concentration (wet wt) in bone | Female | Adult | 3/group | 49 mg/d (lead shot) | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 0.357 (0.012 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in liver | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
LEAD COMPOUNDS | 7.63 (1.03 SE) ppm at 29.3 ppm | mean lead concentration (wet wt) in bone | Female | Adult | 3/group | 29.3 ppm | TOX-EXP IND - accumulation | 60 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CARBOFURAN | 3 | number of dead kestrels found on treated fields | Not Reported | Not Reported | 44 fields | 0.23 kg/305 m application | TOX-MORT - mortality in the field | NR | field application | Toxicity Factor Datasets |
CARBOFURAN | 1.7-7.4 ppm (wet wt) | carcass residues of kestrels found dead | Not Reported | Not Reported | 3 birds | 0.23 kg/305 m application | TOX-EXP IND - accumulation | NR | multiple | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | no effect | variance in kestrel response time to prey stimulus | Not Reported | Adult | 6 | 6 ppm (wet wt) | TOX-Non-Repro-Sublethal - behavioral effects | 40 d | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 1.37 (0.10 SE) mg/kg | mean DDE concentration in blood (wet wt) | Not Reported | Adult | 6 | 6 ppm (wet wt) | TOX-EXP IND - accumulation | 58 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at 10 ppm | mean eggshell thickness | Female | Adult | 8-10 | 0, 10 ppm (dry wt) | TOX-REPRO - physiology | 1 yr | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 0.71 (0.05 SE) ppm at 0 ppm, 32.4 (2.78 SE) ppm at 10 ppm | mean residues in eggs | Female | Embryo | 9-10 | 0, 10 ppm (dry wt) | TOX-EXP IND - accumulation | 1 yr | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | decrease at 3 ppm | mean eggshell thickness | Female | Adult | 18 | 0, 3 ppm | TOX-REPRO - physiology | 6 mo | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
EPN | 4.0 mg/kg bw (3.1-5.1 95% CI) | LD50 | Both Male and Female | Adult | 5/group | 2.2-11 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
FENTHION | 1.4 mg/kg bw | LD50 | Both Male and Female | Adult | 5/group | 0.5-2.4 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
CARBOFURAN | 0.6 mg/kg bw (0.5-1.0 95% CI) | LD50 | Both Male and Female | Adult | 5/group | 0.3-1.8 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
MONOCROTOPHOS | 1.5 mg/kg bw | LD50 | Both Male and Female | Adult | 5/group | 0.7-3.3 mg/kg bw | TOX-MORT - toxicity benchmarks | single | oral intubation | Toxicity Factor Datasets |
EPN | 68% (10.0 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 12 | 2.2-11 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
FENTHION | 88% (2.7 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 8 | 0.5-2.4 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
CARBOFURAN | 83% (4.3 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 12 | 0.3-1.8 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 984.1-1438.6 ppm (dry wt) | brain residues in birds that died | Male | Adult | 2 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 14-16 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 232.9 ppm (dry wt) | mean brain residues in birds that survived | Male | Adult | 11 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 12-15 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 507-877.1 ppm (dry wt) | liver residues in birds that died | Male | Adult | 2 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 14-16 mos | diet | Toxicity Factor Datasets |
DDE (4,4'-) | 88.1 ppm (dry wt) | mean liver residues in birds that survived | Male | Adult | 11 | 10 ppm (dry wt) | TOX-EXP IND - accumulation | 12-15 mos | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 10% decrease | eggshell thickness change relative to control | Female | Adult | Cayuga Lake Basin | 34 eggs | 33.2-41.9 ppm (dry wt) in eggs | TOX-REPRO - physiology | NR | parent diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
FENTHION | 100% | Male | Adult | 14 | 1.1-6.1 ug/g sparrow | TOX-MORT - dose-response data | 1-3 d | diet | Toxicity Factor Datasets | |
FENTHION | 77.9-92% | range of brain acetylcholinesterase inhibition (relative to control) in birds that died | Male | Adult | 14 | 1.1-6.1 ug/g sparrow | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1-3 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
MONOCROTOPHOS | 89% (2.7 SD) | mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose | Both Male and Female | Adult | 15 | 0.7-3.3 mg/kg bw | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral intubation | Toxicity Factor Datasets |