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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | 0.22 mg/kg bw (95% CI; 0.15 - 0.34 mg/kg) | LD50 | Not Reported | Adult | 2 animals/dose | 0.10, 0.15, 0.22, 0.33 mg/kg bw | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
STRYCHNINE | 0.75 mg/kg bw (95% CI; 0.33-1.69 mg/kg) | LD50 | Not Reported | Adult | 2 animals/dose | 0.5, 0.7, 1.0, 1.6 mg/kg bw | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
ZINC PHOSPHIDE | 93 mg/kg bw (95% CI; 62-140 mg/kg) | LD50 | Not Reported | Adult | 2 animals/dose | 62, 94, 140, 210 mg/kg bw | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
HEXACHLOROETHANE | decrease | mean chromosomal abberrations per cell, compared to controls (not exposed to obscurant smoke) | Not Reported | Not Reported | Goldstone, Fort Irwin | 3-4/group | control site and site 15 m from smoke source of fogoil and hexachloroethane | TOX-Non-Repro-Sublethal - genetic effects | 30 min. | site contamination | Toxicity Factor Datasets |
HEXACHLOROETHANE | no effect | sister chromatid exchange counts, compared to controls | Not Reported | Not Reported | Goldstone, Fort Irwin | 3-4/group | control site and site 15 m from smoke source of fogoil and hexachloroethane | TOX-Non-Repro-Sublethal - genetic effects | 30 min. | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLPARATHION | no effect | discrimination between seeds and beads | Both Male and Female | Adult | 22 animals | control, 5 mg/kg bw | TOX-Non-Repro-Sublethal - behavioral effects | single dose | gavage | Toxicity Factor Datasets |
METHYLPARATHION | 18-19 % decrease | brain cholinesterase activity, compared to control | Both Male and Female | Adult | 2 animals | control, 5 mg/kg bw | TOX-EXP IND - biomarkers | single dose | gavage | Toxicity Factor Datasets |
METHYLPARATHION | 97.1 mg/kg (95% CI, 42.6-178.6 mg/kg) | LD50 | Both Male and Female | Adult | 3-4 animals/group | 0,35,56,90,143 mg/kg | TOX-MORT - dose-response data | single dose | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
STRYCHNINE | increase at 6.7-44.5 mg/kg bw | Both Male and Female | Not Reported | 3-5/group | 0.01, 0.05, 0.5%; also reported as 1.4, 6.7, 44.5 mg/kg bw | TOX-MORT - dose-response data | 24 hr | drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | 182-1309 ppb wet wt. @ 0.8 mg/kg; 535-9754 ppb wet wt. @ 4.8 mg/kg | range of fluoroacetate residues in brain, caecum, kidney, liver, spleen, muscle and lung tissue of dead squirrels | Not Reported | Adult | 2/dose | 0, 0.8, 4.8 mg 1080/kg bw | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | decrease @ 6.7 kg/ha | population size | Not Reported | Not Reported | Exeter, Tulare | 38.7-54.2 mean squirrel population size range | 6.7 kg/ha; 13.5 ppm in stomach | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
CRUDE OILS | review | Not Reported | Not Reported | Not Reported | multiple | TOX-Non-Repro-Sublethal - whole animal | NR | NR | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | 0.347 mg/kg (95% CI; 0.212 - 0.541 mg/kg) | median lethal dose | Not Reported | Not Reported | 5-6 animals/dose | 0.125, 0.250, 0.5, 0.75 mg/kg | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | 165 mg administered to coyote (95%CI; 107 - 392 mg) | LD50; based on dose given to coyote; skunks were fed contaminated coyote tissue | Not Reported | Not Reported | 1-8 per dose | secondary; 4; 50; 100; 200; 400 mg to coyote | TOX-MORT - toxicity benchmarks | single | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARA-AMINOPROPIOPHENONE | > 400 mg/kg | LD50 | Not Reported | Not Reported | 2/dose | 3 doses | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PARA-AMINOPROPIOPHENONE | 5.6 [3.0-10.4 (95% CI)] mg/kg | LD50 | Not Reported | Not Reported | 4/dose | 3 doses | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DIPHACINONE | 0.6 [0.3 - 1.2 (95% CL)] mg/kg | LD50 | Both Male and Female | Adult | 2/dose | 0, 0.16, 0.31, 0.63, 1.25, 2.5, 5.0 and 10.0 mg/kg | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
LITHIUM CHLORIDE | decrease @ 18g/1500 g/d | body weight gain in nursing pups of mothers fed LiCl contaminated diet | Both Male and Female | Both Adults and Juveniles | 4 pups/2 adults | 3 or 18 g LiCl/1500 g jackrabbit/d | TOX-Non-Repro-Sublethal - whole animal | 3 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | increase @ 535-9754 ppb | all coyotes died after ingesting 1-2 ground squirrels poisoned with sodium monofluoroacetate | Not Reported | Pup | 2 | 535-9754 ppb wet wt. fluoroacetate in tissues of poisoned squirrels | TOX-MORT - dose-response data | 12 hr | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | increase @ 0.240 - 0.625 mg 1080/kg coyote | 5/6 coyotes died after eating squirrels contaminated with 1080 bait (sodium monofluroacetate) | Not Reported | Adult | 4-6/dose | 0.055 - 0.094 or 0.240-0.625 mg 1080/kg coyote; estimated doses of "low" or "high" contaminated ground squirrels | TOX-MORT - dose-response data | single | diet | Toxicity Factor Datasets |
STRYCHNINE | increase @ 1.321 - 2.860 mg strychnine/kg coyote | 1/4 coyotes died after ingesting contaminated ground squirrels | Not Reported | Adult | 4/dose | 0.275-1.059 or 1.321-2.860 mg strychnine/kg coyote; estimated dose of "low" or "high" contaminated ground squirrels | TOX-MORT - dose-response data | single | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
SODIUM MONOFLUOROACETATE | increase @ 6.7 kg/ha | 5/6 radio-equipped coyotes were found dead during post-treatment period | Not Reported | Not Reported | Exeter, Tulare | 6 | 6.7 kg/ha; 13.5 ppm in stomach of squirrel | TOX-MORT - mortality in the field | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
PENTACHLOROBENZENE | no effect | mean body mass and appearance of eyes, gums, teeth and fur, compared to controls | Both Male and Female | Adult | 3/dose | 0, 65, 130, 260, 520 mg/animal | TOX-Non-Repro-Sublethal - whole animal | single | oral via capsule | Toxicity Factor Datasets |
PENTACHLOROBENZENE | no effect | serum chemistry and hematological profile, compared to control | Both Male and Female | Adult | 3/dose | 0, 65, 130, 260, 520 mg/animal | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | oral via capsule | Toxicity Factor Datasets |
PENTACHLOROBENZENE | see citation | figures of feces and serum concentrations over time at the tested doses | Both Male and Female | Adult | 3/dose | 0, 65, 130, 260, 520 mg/animal | TOX-EXP IND - accumulation | single | oral via capsule | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, CHROMIUM COMPOUNDS, COPPER COMPOUNDS, LEAD COMPOUNDS, SELENIUM COMPOUNDS, ZINC COMPOUNDS | increase | incidence of epileptiform seizures and subsequent death associated with "unusual" Se levels | Female | Adult | 1 | range of metal residue levels in brain, liver, heart, muscle and fat (ppm dry wt); Cd, 0.18 - 3.03; Cr, 1.24-2.39; Cu 1.86 - 87.74; Pb, 77.21-110.90; Se 222-255; Zn 4.89-240.28 | TOX-Non-Repro-Sublethal - whole animal | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDT (Technical Grade Mixture), POLYCHLORINATED BIPHENYLS | increase | incidence of premature parturtion associated with elevated DDT and PCB residues, compared to full term parturient group | Female | Adult | San Miguel Island | 4-6/group | Premature parturient group (ppm wet wt): DDT 824.4 (blubber), PCBs 112.4 (blubber), DDT 25.24 (liver), PCBs 5.74 (liver): Full term parturient group (ppm wt wt): DDT 103.2 (blubber), PCBs 17.1 (blubber), DDT 6.67 (liver), PCBs 1.32 (liver) | TOX-REPRO - physiology | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
SELENIUM COMPOUNDS | 36.11 - 88.4 ug/g wet wt (liver); 7.12 - 32.8 ug/g wet wt (kidney) | selenium concentration range in liver and kidney of dead animals | Not Reported | Not Reported | 3 | fish diet Se concn. range; 0.70 - 1.06 ug/g wet wt | TOX-EXP IND - accumulation | NR | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-), POLYCHLORINATED BIPHENYLS | increase | incidence of premature parturition associated with elevated DDT and PCB levels, compared to full term parturient group | Female | Adult | San Miguel Island | 10/group | Premature parturient group (ppm wet wt): p,p'-DDE 350-939 (blubber), PCBs 33.0-92.4 (blubber); p,p'-DDE 8.54-30.4 (liver), PCBs 0.63-6.08 (liver): Full term parturient group (ppm wt wt): p,p'-DDE 16.3-342 (blubber), PCBs 4.73-39.5 (blubber); p,p'-DDE 0.93 | TOX-REPRO - physiology | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, DDT (Technical Grade Mixture), MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS | increase | incidence of kidney histopathological lesions in "sick" or dead animals compared to "healthy" animals, consistent with diagnosis of leptospirosis | Male | Adult | 2-8/group | residues significantly different between groups (ppm, wet wt): "Sick"; Hg 127.5 - 170.1(liver), Cd 0.17 (cerebellum), DDE 23.9 (liver), PCBs 2.79 (liver): "Healthy"; Hg 74.1 - 95.7 (liver), Cd 0.042 (cerebellum), DDE 11.1 (liver), PCBs 4.87(liver) | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
BROMINE COMPOUNDS, CADMIUM COMPOUNDS, COPPER COMPOUNDS, IRON COMPOUNDS, MANGANESE COMPOUNDS, MERCURY COMPOUNDS, SELENIUM COMPOUNDS, SILVER COMPOUNDS, ZINC COMPOUNDS | increase | incidence of premature parturition correlated with different metal concentrations and ratios | Both Male and Female | Both Adults and Juveniles | 10/group | see citation for table of residue data for 13 metals in pre-term vs full-term mothers and pups | TOX-REPRO - physiology | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
MALATHION | no effect | population size in sprayed areas, compared to control areas | Not Reported | Not Reported | Lexington, Dawson County | Not Reported | control or 0.585 liters/acre | TOX-POP - size effects | single application | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | increase | population size at contaminated vs reference sites | Both Male and Female | Both Adults and Juveniles | Rocky Mountain Arsenal National Wildlife Refuge | Not Reported | Average soil dieldrin concentrations (ppb) at Reference (4.6 - 5.1 ppb) and Contaminated (72.8 - 636.7 ppb) sites | TOX-POP - size effects | NR | site contamination | Toxicity Factor Datasets |
DIELDRIN | increase | % of female deer mice exhibiting signs of reproduction increased as dieldrin levels increased at contaminated vs control sites | Female | Adult | Rocky Mountain Arsenal National Wildlife Refuge | Not Reported | Average soil dieldrin concentrations (ppb) at Reference (4.6 - 5.1 ppb) and Contaminated (72.8 - 636.7 ppb) sites | TOX-REPRO - reproductive success | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TIN, BUTYL | increase | otters that died of infectious disease contained butyltin liver concentrations greater than those that died of trauma | Both Male and Female | Adult | 8-14 animals | mean liver butyltin residue levels in otters where disease was cause of death = 1570 (range = 40-5300 ng/g wet wt) compared to those that died of trauma = 220 (range = 92-480 ng/g wet wt) | TOX-MORT - mortality in the field | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
DDD (4,4'-), DDE (4,4'-), DDT (4,4'-) | increase | otters that died from infectious diseases contained higher liver DDTs concentrations that those that died of trauma | Both Male and Female | Adult | 4-8 | mean liver DDTs residues in otters where disease was cause of death = 2000 (range = 290-4700 ng/g wet wt) compared to those that died of trauma = 1400 (range = 280 - 3800 ng/g wet wt) | TOX-MORT - mortality in the field | NR | site contamination | Toxicity Factor Datasets |