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Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | decrease @ 3.61 kg/ha | population density in enclosures with mowed alfalfa | Both Male and Female | Both Adults and Juveniles | Hyslop Crop Science Field Laboratory, Corvallis | 0-30 animals/enclosure; 4 enclosures/dose | 0, 0.88, 3.61 kg/ha | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DIELDRIN | decrease at 5 mg/kg | homing orientation test, measured as time in maze pointing to capture site | Both Male and Female | Both Adults and Juveniles | NR | 15 animals/dose | 0, 5 mg/kg | TOX-Non-Repro-Sublethal - behavioral effects | single | intraperitoneal | Toxicity Factor Datasets |
DIELDRIN | decrease at 5 mg/kg | homing, measured as number recaptured at pre-exposure site | Both Male and Female | Both Adults and Juveniles | NR | 15 animals/dose | 0, 5 mg/kg | TOX-Non-Repro-Sublethal - behavioral effects | single | intraperitoneal | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | no effect | population density (decreases) | Both Male and Female | Both Adults and Juveniles | University of British Columbia Research Forest, Maple Ridge, British Columbia | Not Reported | 2.2 kg/ha | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
TERBUFOS | increase @ 1.69 and 2.48 mg/kg | Both Male and Female | Not Reported | 70 animals/dose | 0, 0.92, 1.69 and 2.48 g active ingredient/kg | TOX-MORT - dose-response data | single | gavage | Toxicity Factor Datasets | |
TERBUFOS | decrease at 1.69 and 2.48 mg/kg | brain cholinesterase activity | Both Male and Female | Not Reported | 70 animals/dose | 0, 0.92, 1.69 and 2.48 g active ingredient/kg | TOX-Non-Repro-Sublethal - cellular/biochemical effects | single | gavage | Toxicity Factor Datasets |
TERBUFOS | increase @ 1.69 and 2.48 mg/kg | incidence of tremors and rapid breathing | Both Male and Female | Not Reported | 70 animals/dose | 0, 0.92, 1.69 and 2.48 g active ingredient/kg | TOX-Non-Repro-Sublethal - behavioral effects | single | gavage | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|
ALDICARB | no effect | food intake | Female | 8 animals/dose | 0, 10, 10,000 ug/l | TOX-Non-Repro-Sublethal - behavioral effects | 44 d | drinking water | Toxicity Factor Datasets |
ALDICARB | no effect | growth rate estimated by changes in body weight | Female | 8 animals/dose | 0, 10, 10,000 ug/l | TOX-Non-Repro-Sublethal - organ/system effects | 44 d | drinking water | Toxicity Factor Datasets |
ALDICARB | no effect | daily activity measured as time spend in burrow or moving in/out of burrow | Female | 8 animals/dose | 0, 10, 10,000 ug/l | TOX-Non-Repro-Sublethal - behavioral effects | 44 d | drinking water | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHIOCARB | effect @ 0.03-0.5% | suppression of feeding on treated corn | Both Male and Female | Not Reported | 10 - 12 animals/dose | 0, 0.03, 0.125, 0.5% active ingredient by weight of corn seed | TOX-Non-Repro-Sublethal - behavioral effects | 1 - 6 d | diet | Toxicity Factor Datasets |
THIRAM | effect at 0.03-0.5% | suppression of feeding on treated corn | Both Male and Female | Not Reported | 10 - 12 animals/dose | 0, 0.31, 1.25% active ingredient by weight of corn seed | TOX-Non-Repro-Sublethal - behavioral effects | 1 - 6 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | no effect | recruitment measured as number of new animals that entered the population through reproduction or immigration in treated and control areas | Both Male and Female | Both Adults and Juveniles | University of British Columbia Research Forest, Maple Ridge, British Columbia | Not Reported | 0, 3.0 kg active ingredient /ha | TOX-POP - size effects | single | field application | Toxicity Factor Datasets |
GLYPHOSATE | no effect | body weight | Both Male and Female | Both Adults and Juveniles | University of British Columbia Research Forest, Maple Ridge, British Columbia | 67 - 138 animals | 0, 3.0 kg active ingredient /ha | TOX-Non-Repro-Sublethal - whole animal | single | field application | Toxicity Factor Datasets |
GLYPHOSATE | no effect | growth rate, estimated by changes in body weight | Both Male and Female | Juvenile | University of British Columbia Research Forest, Maple Ridge, British Columbia | 23 - 55 | 0, 3.0 kg active ingredient /ha | TOX-REPRO - development | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
RADIONUCLIDES | 160 +/- 162SE mrem/d; range = 7-982 mrem/d | whole animal dose estimated with implanted dosimeters | Not Reported | Not Reported | test reactor area, Idaho National Engineering Lab | 70 animals | Air: 10 - 2000 mroetgen/d | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
AMINOCARB | no effect | mean activity level estimated by frequency of crossing sand transects | Not Reported | Not Reported | southwestern Quebec [lat., 46^oN; long., 74^o10'W] | Not Reported | 0, 175 g active ingredient/ha | TOX-Non-Repro-Sublethal - behavioral effects | single | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
LEAD COMPOUNDS | Bone; 52.10 +/- 33.81SD, Kidney; 8.46 +/- 3.03SE, Liver; 3.29 +/- 1.77SD, Brain; 0.84 +/- 0.25SE, Feces; 153.6+/- 103.5SD ppm (dry weight) | Mean concentrations in deer mice from roadside site (ppm, dry weight). Feces collected from nest box after 1 yr accumulation. Roadside tissue concentrations significantly different from control site. | Both Male and Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 9 - 10 animals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-EXP IND - accumulation | NR | multiple | Toxicity Factor Datasets |
LEAD COMPOUNDS | no effect | number of litters per 100 breeding females, measured by observing litters in nesting boxes at a control and roadside site | Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 50 nesting boxes, 66 observation periods nimals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-REPRO - reproductive success | NR | multiple | Toxicity Factor Datasets |
LEAD COMPOUNDS | significant increase | mortality during winter, estimated by number of mice recaptured the following breeding season at a control and roadside site | Both Male and Female | Adult | Interstate 25, Denver (elev. 1884-2018 m) | 98 - 180 tagged animals | mean surface soil; 73.0 +/- 19.9SD ppm, dry weight | TOX-MORT - mortality in the field | NR | multiple | Toxicity Factor Datasets |
LEAD ACETATE | increase at 0.5 and 1% diet | incidence of acid-fast staining intranuclear inclusion bodies within kidney proximal convoluted tubule cells | Both Male and Female | Adult | 5 breeding pairs/dose | 0, 0.1, 0.5, 1.0% | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 26 wk | diet | Toxicity Factor Datasets | |
LEAD ACETATE | no effect | litter mortality | Both Male and Female | Adult | 5 breeding pairs | 0, 0.1, 0.5, 1.0% | TOX-REPRO - reproductive success | 26 wk | diet | Toxicity Factor Datasets | |
LEAD ACETATE | no effect | incidence of congenital malformations | Both Male and Female | Juvenile | 5 breeding pairs/dose | 0, 0.1, 0.5, 1.0% | TOX-REPRO - development | 26 wk | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
AZINPHOS-METHYL (GUTHION) | 48 mg/kg bw (95% CL: 39-74 mg/kg, slope = 2.57 +/- 0.73SE) | LD50 | Male | Adult | 5-7 animals/dose | 0, 20, 25, 32, 40, 50, 63, 79 mg/kg body weight | TOX-MORT - toxicity benchmarks | single | gavage | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 1180 ppm diet (95% CL: 709-1485, slope = 1.88 +/- 0.57SE) | LD50 | Both Male and Female | Adult | 10 animals/dose | 6 doses | TOX-MORT - toxicity benchmarks | 10 d | diet | Toxicity Factor Datasets |
AZINPHOS-METHYL (GUTHION) | 2425 ppm diet (95% CL: 1856-3245, slope = 1.45 +/- 0.25SE) | LD50 | Both Male and Female | Adult | 10 animals/dose | 6 doses | TOX-MORT - toxicity benchmarks | 5 d | diet | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
MERCURY COMPOUNDS | increase and decrease | decreased swimming ability, increased time for mouse to leave circle in center of field, decreased number of lines crossed and increased number of backward movements compared to a reference site | Male | Adult | Bird Island, Great Salt Lake | 7 - 14 animals | Mean hair concentration; 10.8 +/- 2.0 ppm | TOX-Non-Repro-Sublethal - behavioral effects | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, COPPER COMPOUNDS, ZINC COMPOUNDS | Diet:Soil; 128.0 (Cd), 1.31 (Cu), 1.87 (Zn). Liver:Soil; 35.3 (Cd), 0.17 (Cu), 1.25 (Zn). Liver:Diet; 0.27 (Cd), 0.12 (Cu), 0.66 (Zn). | Ratio of metal concentrations (ug/g dry weight) in diet:soil, liver:soil and liver:diet at an abandoned mine site. Diet concentrations measured from stomach contents. Soil based on acid extractable concentrations. Soil copper; liver cadmium, copper an | Both Male and Female | Adult | Blue Grouse Mountain Copper Mine, Honeymoon Bay, Vancouver Island, British Columbia | 6-9 soil or tissue samples/site | Soil: 0.21 +/- 0.006 SD (Cd), 315.0 +/- 3.15SD (Cu), 80.6 +/- 10.4SD (Zn) mg/kg dry weight | TOX-EXP IND - accumulation | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
GLYPHOSATE | no effect | population density, compared to control site | Both Male and Female | Both Adults and Juveniles | Maple Ridge, British Columbia | 13 trapping periods | 0, 3.0 kg/ha | TOX-POP - size effects | up to 4 yr | field application | Toxicity Factor Datasets |
GLYPHOSATE | increase | % of trapped males and females in breeding condition, compared to control site | Both Male and Female | Adult | Maple Ridge, British Columbia | 24 - 62 animals | 0, 3.0 kg/ha | TOX-REPRO - physiology | up to 4 yr | field application | Toxicity Factor Datasets |
GLYPHOSATE | no effect | average duration of life during summer and winter periods | Both Male and Female | Adult | Maple Ridge, British Columbia | 2 - 40 animals | 0, 3.0 kg/ha | TOX-MORT - mortality in the field | up to 4 yr | field application | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|
METHYLCHLORANTHRENE (3-) | 0.14 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
METHYLCHLORANTHRENE (3-) | 1.24 mg/kg/d | ED50 for ethoxyresorufin-O-dealkylase (EROD) activity | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIBENZ[A]ANTHRACENE (1,2,5,6-) | 0.048 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIBENZ[A]ANTHRACENE (1,2,5,6-) | 0.85 mg/kg/d | ED50 for ethoxyresorufin-O-dealkylase (EROD) activity | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - cellular/biochemical effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
DIMETHYLBENZ[A]ANTHRACENE (7,12-) | 0.026 mg/kg/d | ED50 for immunosuppression, measured as suppression of plaque forming cell response | Male | Juvenile | Not Reported | NR | TOX-Non-Repro-Sublethal - organ/system effects | 1, 3, 5, 7, 9 d | intraperitoneal | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
CADMIUM COMPOUNDS, LEAD COMPOUNDS, MERCURY COMPOUNDS, POLYCHLORINATED BIPHENYLS, SELENIUM COMPOUNDS | no effect | incidence of liver and kidney histopathologies was not related to contaminant concentrations | Not Reported | Not Reported | salt marsh, San Pablo and San Francisco Bays | 26 animals | Range of tissue means (ppm, dry wt.): Liver; 0.05-1.08 (mercury), 2.32-3.53 (selenium). Kidney; 0.4-2.11 (cadmium), 0.6-1.92 (lead). Carcass; 0.02-0.22 (PCBs). | TOX-Non-Repro-Sublethal - cellular/biochemical effects | NR | site contamination | Toxicity Factor Datasets |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Location | Sample Size | Tox Exposure | Toxicity Endpoint Type | Tox Exposure Duration | Tox Exposure Technique | Type |
---|---|---|---|---|---|---|---|---|---|---|---|
DDE (4,4'-) | 5.8 ppm; range, 3.6-8.2 ppm (wet wt) | mean and range of concentration in carcass, wet wt | Both Male and Female | Adult | near cities | 4 bats | NR | TOX-EXP IND - accumulation | NR | NR | Toxicity Factor Datasets |
DDD (4,4'-) | 0.1 ppm; range, <0.1-0.3 ppm (wet wt) | mean and range of concentration in carcass, wet wt | Both Male and Female | Adult | near cities | 4 bats | NR | TOX-EXP IND - accumulation | NR | NR | Toxicity Factor Datasets |
DDT (4,4'-) | 1.8 ppm; range, 0.6-3.8 ppm (wet wt) | mean and range of concentration in carcass, wet wt | Both Male and Female | Adult | near cities | 4 bats | NR | TOX-EXP IND - accumulation | NR | NR | Toxicity Factor Datasets |