TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-)

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Double-crested Cormorant (Phalacrocorax auritus)

Citation:

Accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North American Great Lakes

Author(s)
Jones, P.D., J.P. Giesy, J.L. Newsted, D.A. Verbrugge, J.P. Ludwig, M.E. Ludwig, H.J. Auman, R. Crawford, D.E. Tillitt, T.J. Kubiak, and D.A. Best
Pages
192-209
Year
Volume
27
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 37.6 pg/g bw gained (wet wt) pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) Not Reported Nestling 20 chicks Thunder Bay, Lake Huron Toxicity Factor Datasets
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 28.3 pg/g bw gained (wet wt) pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) Not Reported Nestling 20 chicks North Channel, Lake Huron Toxicity Factor Datasets
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 47.5 pg/g bw gained (wet wt) pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) Not Reported Nestling 20 chicks St. Martin's Shoal, Lake Huron Toxicity Factor Datasets
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 31.3 mean biomagnification factor for eggs from forage fish Female Adult 12 eggs/site x 5 sites Toxicity Factor Datasets
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 162.4 pg/g bw gained (wet wt) pg TCDD equivalents accumulated per gram of body weight gained (from eggs to largest chicks) Not Reported Nestling 20 chicks Green Bay, Lake Michigan Toxicity Factor Datasets
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 100.4 pg/g bw gained (wet wt) pg TCDD equivalents accumulated per gram of body weight gained from egg to largest chick stage Not Reported Nestling 20 chicks Beaver Islands, Lake Michigan Toxicity Factor Datasets
Citation:

Effects of 3,3',4,4',5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin injected into the yolks of double-crested cormorant (Phalacrocorax auritus) eggs prior to incubation

Author(s)
Powell, Debra, Richard J. Aulerich, John C. Meadows, Don E. Tillitt, Mary E. Kelly, Kenneth L. Stromborg, Mark J. Melancon, Scott D. Fitzgerald, and Steven J. Bursian
Pages
2035-2040
Year
Issue
10
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) increased @ 5.4, 10.7, 11.7 ug/kg egg mortality in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) 4.0 ug/kg egg (0.8-7.2) LD50 (95% confidence limits) Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) increased @ all doses hepatic EROD activity in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) decreased @ 5.4, 11.7 ug/kg egg spleen weights in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
Citation:

Hepatic microsomal ethoxyresorufin O-deethylase-inducing potency in ovo and cytosolic Ah receptor binding affinity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: comparison of four avian species

Author(s)
Sanderson, J. Thomas and Gail D. Bellward
Pages
131-145
Year
Volume
132
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) observed at 3, 10, 100 ug/kg mortality Not Reported Hatchling 6-10 eggs/dose Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect body and organ weights Not Reported Hatchling 6-10 eggs/dose Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) observed at 3, 10, 100 ug/kg edema Not Reported Hatchling 6-10 eggs/dose Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) increased at 10, 100 ug/kg hepatic microsomal cytP450 content Not Reported Hatchling 6-10 eggs/dose Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) increased at 3, 10, 100 ug/kg hepatic microsomal EROD activity Not Reported Hatchling 6-10 eggs/dose Toxicity Factor Datasets Laboratory
Citation:

Effects of 3,3',4,4',5-pentacholorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs

Author(s)
Powell, Debra C., Richard J. Aulerich, John C. Meadows, Donald E. Tillit, Jon F. Powell, Janelle C. Restum, Kenneth L. Stromborg, John P. Giesy and Steven J. Bursian
Pages
1450-1455
Year
Issue
7
Volume
16
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) increased at 4.0 ug/kg egg incidence of embryo mortality versus controls Not Reported Hatchling 58-60/group Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect weight of brain, heart, liver and spleen versus controls Not Reported Hatchling Not Reported Toxicity Factor Datasets Laboratory

Bullfrog (Lithobates catesbeianus formerly Rana catesbeiana)

Citation:

Toxicity of 2,3,7,8-tetrachloro-p-dioxin in larval and adult forms of Rana catesbeiana

Author(s)
Beatty, Patrick W., Myron A. Holscher and Robert A. Neal
Pages
578-581
Year
Issue
5
Volume
16
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect Not Reported Tadpole 15 animals/group Toxicity Factor Datasets Taylor-Kollros stages I-VII Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect incidence of morphological abnormalities Not Reported Tadpole 15 animals/group Toxicity Factor Datasets Taylor-Kollros stages I-VII Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect Both Male and Female Adult 5 animals/group Toxicity Factor Datasets Laboratory
TETRACHLORODIBENZO-P-DIOXIN (2,3,7,8-) no effect histopathological changes in liver, kidney, lung, heart and gonads Both Male and Female Adult 5 animals/group Toxicity Factor Datasets Laboratory
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